Cover, Cathleen, Fickert, Peter, Knight, Tamara R., Fuchsbichler, Andrea, Farhood, Anwar, Trauner, Michael, ...
DNA fragmentation in hepatocytes occurs early after acetaminophen (AAP) overdose in mice. DNA strandbreaks can induce excessive activation of poly(ADP-ribose) polymerases (PARP), which may lead to...
Cover, Cathleen, Fickert, Peter, Knight, Tamara R., Fuchsbichler, Andrea, Farhood, Anwar, Trauner, Michael, ...
DNA fragmentation in hepatocytes occurs early after acetaminophen (AAP) overdose in mice. DNA strandbreaks can induce excessive activation of poly(ADP-ribose) polymerases (PARP), which may lead to...
Lithocholic Acid Feeding Induces Segmental Bile Duct Obstruction and Destructive Cholangitis in Mice
Fickert, Peter, Fuchsbichler, Andrea, Marschall, Hanns-Ulrich, Wagner, Martin, Zollner, Gernot, Krause, Robert, ...
We determined the mechanisms of hepatobiliary injury in the lithocholic acid (LCA)-fed mouse, an increasingly used model of cholestatic liver injury. Swiss albino mice received control diet or 1%...
Stumptner, Cornelia, Heid, Hans, Fuchsbichler, Andrea, Hauser, Hubert, Mischinger, Hans-Jörg, Zatloukal, Kurt, ...
Intracytoplasmic hyaline bodies (IHBs) resemble inclusions in hepatocellular carcinoma cells, which so far have escaped further characterization. A relationship to Mallory bodies was suggested on the...
Cytokeratins as Targets for Bile Acid-Induced Toxicity
Fickert, Peter, Trauner, Michael, Fuchsbichler, Andrea, Stumptner, Conny, Zatloukal, Kurt, Denk, Helmut
Cholestasis is associated with retention of potentially toxic bile acids and profound cytoskeletal alterations of hepatocytes. Given the well-established cytoprotective role of hepatocyte keratins...
Bile Acid-Induced Mallory Body Formation in Drug-Primed Mouse Liver
Fickert, Peter, Trauner, Michael, Fuchsbichler, Andrea, Stumptner, Conny, Zatloukal, Kurt, Denk, Helmut
Chronic cholestasis is associated with retention of bile acids and profound cytoskeletal alterations in hepatocytes including Mallory body (MB) formation. The mechanisms responsible for MB formation...
p62 Is a Common Component of Cytoplasmic Inclusions in Protein Aggregation Diseases
Zatloukal, Kurt, Stumptner, Cornelia, Fuchsbichler, Andrea, Heid, Hans, Schnoelzer, Martina, Kenner, Lukas, ...
Exposure of cells to stress, particularly oxidative stress, leads to misfolding of proteins and, if they are not refolded or degraded, to cytoplasmic protein aggregates. Protein aggregates are...
A New Xenobiotic-Induced Mouse Model of Sclerosing Cholangitis and Biliary Fibrosis
Fickert, Peter, Stöger, Ulrike, Fuchsbichler, Andrea, Moustafa, Tarek, Marschall, Hanns-Ulrich, Weiglein, Andreas H., ...
Xenobiotics and drugs may lead to cholangiopathies and biliary fibrosis, but the underlying mechanisms are largely unknown. Therefore, we aimed to characterize the cause and consequences of...
Functions of c-Jun in Liver and Heart Development
Eferl, Robert, Sibilia, Maria, Hilberg, Frank, Fuchsbichler, Andrea, Kufferath, Iris, Guertl, Barbara, ...
Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is known about the cell types affected as well as the cause of embryonic lethality. Here we show that a...