Pöhlmann, Stefan, Davis, Carl, Meister, Silke, Leslie, George J., Otto, Claas, Reeves, Jacqueline D., ...
The V3 loop of the simian immunodeficiency virus (SIV) envelope protein (Env) largely determines interactions with viral coreceptors. To define amino acids in V3 that are critical for coreceptor...
Hofmann, Heike, Hattermann, Kim, Marzi, Andrea, Gramberg, Thomas, Geier, Martina, Krumbiegel, Mandy, ...
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes severe pneumonia with a fatal outcome in approximately 10% of patients. SARS-CoV is not closely related to other...
Marzi, Andrea, Gramberg, Thomas, Simmons, Graham, Möller, Peggy, Rennekamp, Andrew J., Krumbiegel, Mandy, ...
The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR...
Marzi, Andrea, Akhavan, Armin, Simmons, Graham, Gramberg, Thomas, Hofmann, Heike, Bates, Paul, ...
The C-type lectins DC-SIGN and DC-SIGNR (collectively referred to as DC-SIGN/R) bind to the ebolavirus glycoprotein (EBOV-GP) and augment viral infectivity. DC-SIGN/R strongly enhance infection...
Pöhlmann, Stefan, Davis, Carl, Meister, Silke, Leslie, George J., Otto, Claas, Reeves, Jacqueline D., ...
The V3 loop of the simian immunodeficiency virus (SIV) envelope protein (Env) largely determines interactions with viral coreceptors. To define amino acids in V3 that are critical for coreceptor...
Hofmann, Heike, Hattermann, Kim, Marzi, Andrea, Gramberg, Thomas, Geier, Martina, Krumbiegel, Mandy, ...
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes severe pneumonia with a fatal outcome in approximately 10% of patients. SARS-CoV is not closely related to other...
Marzi, Andrea, Gramberg, Thomas, Simmons, Graham, Möller, Peggy, Rennekamp, Andrew J., Krumbiegel, Mandy, ...
The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR...
Marzi, Andrea, Akhavan, Armin, Simmons, Graham, Gramberg, Thomas, Hofmann, Heike, Bates, Paul, ...
The C-type lectins DC-SIGN and DC-SIGNR (collectively referred to as DC-SIGN/R) bind to the ebolavirus glycoprotein (EBOV-GP) and augment viral infectivity. DC-SIGN/R strongly enhance infection...
Hofmann, Heike, Simmons, Graham, Rennekamp, Andrew J., Chaipan, Chawaree, Gramberg, Thomas, Heck, Elke, ...
We have recently demonstrated that the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor angiotensin converting enzyme 2 (ACE2) also mediates cellular entry of the newly discovered...
DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets
Chaipan, Chawaree, Soilleux, Elizabeth J., Simpson, Peter, Hofmann, Heike, Gramberg, Thomas, Marzi, Andrea, ...
Platelets can engulf human immunodeficiency virus type 1 (HIV-1), and a significant amount of HIV-1 in the blood of infected individuals is associated with these cells. However, it is unclear how...
Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin▿
Chaipan, Chawaree, Kobasa, Darwyn, Bertram, Stephanie, Glowacka, Ilona, Steffen, Imke, Solomon Tsegaye, Theodros, ...
Proteolytic activation of the hemagglutinin (HA) protein is indispensable for influenza virus infectivity, and the tissue expression of the responsible cellular proteases impacts viral tropism and...
Replication-Deficient Ebolavirus as a Vaccine Candidate▿
Halfmann, Peter, Ebihara, Hideki, Marzi, Andrea, Hatta, Yasuko, Watanabe, Shinji, Suresh, M., ...
Ebolavirus causes severe hemorrhagic fever, with case fatality rates as high as 90%. Currently, no licensed vaccine is available against Ebolavirus. We previously generated a replication-deficient,...