Andreas H. Jacobs

Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma (2007)

Fischer, Yvonne Heidemarie, Giroglou, Tsanan, Rueger, Maria Adele, Winkeler, Alexandra, ...

Purpose: Lentiviral vectors pseudotyped with glycoproteins of the lymphocytic choriomeningitis virus (LCMV-GP) are promising candidates for gene therapy of malignant glioma, as they specifically and...

Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene (2007)

Fischer, Yvonne, Litwak, Sara, Giroglou, Tsanan, Waerzeggers, Yannic, Winkeler, Alexandra, ...

Adult stem cells are promising cellular vehicles for therapy of malignant gliomas as they have the ability to migrate into these tumors and even track infiltrating tumor cells. However, their...

Prospects of molecular imaging in neurology (2002)

Jacobs, Andreas H., Winkeler, A., Dittmar, Claus, Hilker, R., Heiss, Wolf-Dieter

Molecular imaging aims towards the non-invasive kinetic and quantitative assessment and localization of biological processes of normal and diseased cells in vivo in animal models and humans. Due to...

Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas (2002)

Jacobs, Andreas H., Winkeler, A., Dittmar, C., Gossmann, A., Deckert, M., Kracht, Lutz, ...

Gliomas are the most common types of brain tumors, which invariably lead to death over months or years. Before new and potentially more effective treatment strategies, such as gene therapy, can be...

Role for neuronal insulin resistance in neurodegenerative diseases

Schubert, Markus, Gautam, Dinesh, Surjo, David, Ueki, Kojihiko, Baudler, Stephanie, Schubert, Dominic, ...

Impairment of insulin signaling in the brain has been linked to neurodegenerative diseases. To test the hypothesis that neuronal insulin resistance contributes to defects in neuronal function, we...

Imaging in Neurooncology

Jacobs, Andreas H., Kracht, Lutz W., Gossmann, Axel, Rüger, Maria A., Thomas, Anne V., Thiel, Alexander, ...

Summary: Imaging in patients with brain tumors aims toward the determination of the localization, extend, type, and malignancy of the tumor. Imaging is being used for primary diagnosis, planning of...

Role for neuronal insulin resistance in neurodegenerative diseases

Schubert, Markus, Gautam, Dinesh, Surjo, David, Ueki, Kojihiko, Baudler, Stephanie, Schubert, Dominic, ...

Impairment of insulin signaling in the brain has been linked to neurodegenerative diseases. To test the hypothesis that neuronal insulin resistance contributes to defects in neuronal function, we...

Imaging in Neurooncology

Jacobs, Andreas H., Kracht, Lutz W., Gossmann, Axel, Rüger, Maria A., Thomas, Anne V., Thiel, Alexander, ...

Summary: Imaging in patients with brain tumors aims toward the determination of the localization, extend, type, and malignancy of the tumor. Imaging is being used for primary diagnosis, planning of...

Switching on the Lights for Gene Therapy

Winkeler, Alexandra, Sena-Esteves, Miguel, Paulis, Leonie E.M., Li, Hongfeng, Waerzeggers, Yannic, Rückriem, Benedikt, ...

Strategies for non-invasive and quantitative imaging of gene expression in vivo have been developed over the past decade. Non-invasive assessment of the dynamics of gene regulation is of interest for...