Kabil, Alena, Silva, Elisabete, Kortenkamp, Andreas
Reports of the ability of estrogenic agents such as 17β-estradiol (E2), estriol (E3) and bisphenol A (BPA) to induce micronuclei (MN) in MCF-7 breast cancer cells have prompted us to investigate...
Metzdorff, Stine Broeng, Dalgaard, Majken, Christiansen, Sofie, Axelstad, Marta, Hass, Ulla, Kiersgaard, Maria Kristina, ...
We investigated the ability of a mixture of three androgen receptor antagonists to induce disruption of male sexual differentiation after perinatal exposure. The aim was to assess whether the joint...
Defining the Impact of Weakly Estrogenic Chemicals on the Action of Steroidal Estrogens (2001)
Rajapakse, Nissanka, Ong, Delia, Kortenkamp, Andreas
We tested whether bisphenol A (BPA) or o,p′-DDT, when combined with 17&bgr;-estradiol (E2), would contribute to the overall mixture effect using a yeast reporter gene assay, the yeast estrogen...
Kortenkamp, Andreas, Jones, Chris, Baker, Jon
A novel technique for the selection of mutated DNA sequences, termed mismatch cleavage-polymerase chain reaction (MC-PCR), is proposed. The method is based on hybridizing genomic DNA with a suitable...
Casadevall, Montserrat, Kortenkamp, Andreas
The induction of apurinic/apyrimidinic sites (AP sites) and DNA single-strand breaks (SSB) by chromate and glutathione in isolated DNA was investigated using agents that cleave the DNA at AP sites...
The formation of DNA cleaving species during the reduction of chromate by ascorbate (1994)
Da Cruz Fresco, Paula, Kortenkamp, Andreas
A detailed study of the ability of chromate in combination with ascorbate to induce DNA single-strand breaks in the absence of iron(II) and copper(II) has been carried out. In solutions containing 1...
Casadevall, Montserrat, Kortenkamp, Andreas
We have obtained evidence for the induction of apurinic/apyrimidinic sites (AP-sites) in isolated DNA treated with chromate and glutathione using agents that cleave the DNA phosphate backbone at...
Kortenkamp, Andreas, Curran, Brendan, O'Brien, Paul
The formation of cross-links between bovine serum albumin and DNA in the presence of chromium(III) chloride was found to be highly pH dependent. In vitro, such lesions were only formed at acidic...
Kortenkamp, Andreas, O'Brien, Paul
The binding of a number of chromium complexes to ATP has been studied by 31P NMR spactroscopy. The results are consistent with the formation of outer-sphere complexes between ATP and the chromum...
The reduction of chromate is a prerequisite of chromium binding to cell nuclei (1991)
Kortenkamp, Andreas, O'Brien, Paul, Beyersmann, Detmar
Isolated calf thymus nuclei bound a chromium(III) glutathione complex in a time-dependent manner. In contrast chromium(VI) (sodium chromate) did not bind. However, when chromate was incubated with...
Rajapakse, Nissanka, Silva, Elisabete, Kortenkamp, Andreas
The low potency of many man-made estrogenic chemicals, so-called xenoestrogens, has been used to suggest that risks arising from exposure to individual chemicals are negligible. Another argument used...
Rajapakse, Nissanka, Silva, Elisabete, Kortenkamp, Andreas
The low potency of many man-made estrogenic chemicals, so-called xenoestrogens, has been used to suggest that risks arising from exposure to individual chemicals are negligible. Another argument used...
Combined Exposure to Anti-Androgens Exacerbates Disruption of Sexual Differentiation in the Rat
Hass, Ulla, Scholze, Martin, Christiansen, Sofie, Dalgaard, Majken, Vinggaard, Anne Marie, Axelstad, Marta, ...
Ten Years of Mixing Cocktails: A Review of Combination Effects of Endocrine-Disrupting Chemicals
In the last 10 years, good evidence has become available to show that the combined effects of endocrine disruptors (EDs) belonging to the same category (e.g., estrogenic, antiandrogenic, or...