Andreas Schmidt

Schmidt: Socially-Aware Informal Learning Support: Potentials and Challenges of the Social Dimension (2009)

Simone Braun, Andreas Schmidt

Abstract. With increasingly conceiving learning as a social activity, technological support must become more aware of the social context of the individual in order to be able to provide adequate...

Conceptual Foundations for a Service-Oriented Knowledge & Learning Architecture: Supporting Content, Process, and Ontology Maturing (2009)

Andreas Schmidt, Knut Hinkelmann, Stefanie Lindstaedt, Tobias Ley, Ronald Maier, Uwe Riss

Abstract: The knowledge maturing model views learning activities as embedded into, interwoven with, and even indistinguishable from everyday work processes. Learning is understood as an inherently...

Adaptive Reading Assistance for the Inclusion of Learners with Dyslexia: The AGENT-DYSL approach (2009)

Paraskevi Tzouveli, Andreas Schmidt, Michael Schneider, Antonis Symvonis, Stefanos Kollias

Dyslexia is a major barrier to success in education and later on the job as reading skills are fundamental for personal competence development. Children with dyslexia have special learning needs...

Conceptual Foundations for a Service-oriented Knowledge and Learning Architecture: Supporting Content, Process and Ontology Maturing (2009)

Andreas Schmidt, Knut Hinkelmann, Tobias Ley, Stefanie Lindstaedt, Uwe Riss, Andreas Schmidt, ...

Abstract Effective learning support in organizations requires a flexible and personalized toolset that brings together the individual and the organizational perspective on learning. Such toolsets...

User-Driven Semantic Wiki-based Business Service Description (2009)

Heiko Paoli, Andreas Schmidt, Peter C. Lockemann

Abstract A key factor for success of companies operating in a globalized market environment is a modern SOA-based infrastructure. An essential component of a SOA infrastructure is the central service...

Using the Ontology Maturing Process Model for Searching, Managing and Retrieving Resources with Semantic Technologies (2009)

Simone Braun, Andreas Schmidt, Andreas Walter, Valentin Zacharias

Abstract. Semantic technologies are very helpful in improving existing systems for searching, managing and retrieving of resources, e.g. image search, bookmarking or expert finder systems. They...

Gefährdungspotential der eulitoralen Miesmuschelbänke im Niedersächsischen Wattenmeer durch die Bioinvasion der Pazifischen Auster (Crassostrea gigas) (2009)

Schmidt, Andreas

In a world of increasing globalisation nearly all ecosystems become threatened or are affected by alien species. If a species become invasive this can lead to alterations in the recipient region, but...

Situationsbewusste Informationsdienste für das arbeitsbegleitende Lernen (2009)

Schmidt, Andreas

Zunehmend werden Lernen und Arbeiten als miteinander verwobene Aktivitäten verstanden, was von existierenden Ansätzen nur unzureichend unterstützt wird, da sie kaum die Arbeitssituation...

Nonsense Mediated Decay Associated Pioneer Round of Translation as Source for Peptides for Presentation by MHC Class I (2009)

Schmidt, Andreas

Nonsense mediated decay (NMD) plays a critical role in the mRNA quality control mechanism protecting cells from aberrant mRNAs containing premature termination codons (PTC). Recognition of these PTCs...

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA (2009)

Pippig, Diana A., Hellmuth, Johannes C., Cui, Sheng, Kirchhofer, Axel, Lammens, Katja, Lammens, Alfred, ...

RIG-I and MDA5 sense cytoplasmic viral RNA and set-off a signal transduction cascade, leading to antiviral innate immune response. The third RIG-I-like receptor, LGP2, differentially regulates RIG-I-...

Expert Finding as Informal Learning Support: Competency-Aware and Socially-Aware (2008)

Simone Braun, Andreas Schmidt

Abstract. Expert finding goes beyond identifying and locating experts. We see expert finding embedded into informal learning activities where personal and social context plays a decisive role (e.g....

Position Paper Mind the Web (2008)

Valentin Zacharias, Andreas Abecker, Denny Vr, Imen Borgi, Simone Braun, Andreas Schmidt

Abstract. This paper argues that a significant part of today’s Semantic Web research is still dominated by ideas from centralized databases. Furthermore, the main thread of reasoning research...

23.07.02, kazakosUI2002.doc 1 Automation of Metadata Repository Development with XML Schema Abstract (2008)

Wassilios Kazakos, Alexei Valikov, Andreas Schmidt, Rainer Lehfeldt

Metadata standards have been discussed since years in the environmental domain. Although the community has agreed that metadata are important for information finding, an globally accepted standard is...

Adaptive Reading Assistance for Dyslexic Students: Closing the Loop (2008)

Andreas Schmidt, Michael Schneider

Adaptive reading assistance can improve the reading performance of students, but current dyslexia pedagogical theories do not yet provide sound results on a micro-level. We want to provide a reading...

The Ontology Maturing Approach for Collaborative and Work Integrated Ontology Development: Evaluation Results and Future Directions (2008)

Simone Braun, Andreas Schmidt, Andreas Walter, Valentin Zacharias

Abstract. Ontology maturing as a conceptual process model is based on the assumption that ontology engineering is a continuous collaborative and informal learning process and always embedded in tasks...

describing software (2008)

Andreas Schmidt

maturing as a process model for

Load Balancing for Spatial-Grid-Based Parallel Numeric Simulations on Clusters of SMPs (2008)

Huaien Gao, Andreas Schmidt, Amitava Gupta, Peter Luksch

Load distribution is an essential factor to parallel efficiency of numerical simulations that are based on spatial grids, especially on clusters of symmetric multiprocessors (SMPs). This paper...

Sustainable Competency-Oriented Human Resource Development with Ontology-Based Competency Catalogs (2008)

Andreas Schmidt, Christine Kunzmann

Abstract: Competency-oriented approaches are gaining ground in human resource development. Key technology to cope with the complexity of fine-grained approaches are ontologies. By having a formal...

Position Paper Mind the Web (2008)

Valentin Zacharias, Andreas Abecker, Denny Vr, Imen Borgi, Simone Braun, Andreas Schmidt

Abstract. This paper argues that a significant part of today’s Semantic Web research is still dominated by ideas from centralized databases. Furthermore, the main thread of reasoning research...

IMPACT OF CONTEXT-AWARENESS ON THE ARCHITECTURE OF LEARNING SUPPORT SYSTEMS (2008)

Andreas Schmidt

Recently, the situatedness of learning has come to the center of attention in both research and practice, also a result of the insight that traditional learning methods in the form of large...

User-Driven Semantic Wiki-based Business Service Description (2008)

Heiko Paoli, Andreas Schmidt, Peter C. Lockemann

Abstract: A key factor for success of companies operating in a globalized market environment is a modern SOA-based infrastructure. An essential component of a SOA infrastructure is the central...

The Ontology Maturing Approach for Collaborative and Work Integrated Ontology Development: Evaluation Results and Future Directions (2008)

Simone Braun, Andreas Schmidt, Andreas Walter, Valentin Zacharias

Abstract. Ontology maturing as a conceptual process model is based on the assumption that ontology engineering is a continuous collaborative and informal learning process and always embedded in tasks...

Adaptive Reading Assistance for Dyslexic Students: Closing the Loop (2008)

Andreas Schmidt, Michael Schneider

Adaptive reading assistance can improve the reading performance of students, but current dyslexia pedagogical theories do not yet provide sound results on a micro-level. We want to provide a reading...

Semantic Desktop Systems for Context Awareness – Requirements and Architectural Implications (2008)

Simone Braun, Andreas Schmidt, Christina Hentschel

Abstract. Semantic Desktop systems appear to be a promising infrastructure for context-aware applications that acquire and make use of user context information in order to provide more efficient...

Kontext-Middleware zur Verwaltung dynamischer und unvollkommener Kontextinformationen (2008)

Andreas Schmidt, Technologien Aufbaut

Abstract. Gerade in mobilen Anwendungsszenarien steht man vor dem Dilemma der Anfrageformulierung in Informationssystemen: entweder präzise und hoch selektive Anfragen oder eine einfache,...

A Graph-matching based Intra-node Task Assignment Methodology for SMP Clusters (2008)

Huaien Gao, Andreas Schmidt, Amitava Gupta, Peter Luksch

Load distribution for parallel applications on a cluster of Symmetrical Multi-processors(SMP) poses a challenging problem. A cluster of SMPs essentially comprises of a finite number of computing...

Microlearning and the Knowledge Maturing Process: Towards Conceptual Foundations for Work-Integrated Microlearning Support (2008)

Andreas Schmidt

Abstract: As a response to the new flexibility in work environments, work-integrated learning on demand is an appropriate form of learning which is in line with microlearning ideas. But in a world of...

Expert Finding as Informal Learning Support: Competency-Aware and Socially-Aware (2008)

Simone Braun, Andreas Schmidt

Abstract. Expert finding goes beyond identifying and locating experts. We see expert finding embedded into informal learning activities where personal and social context plays a decisive role (e.g....

Socially-Aware Informal Learning Support: (2008)

Potentials And Challenges, Simone Braun, Andreas Schmidt

With increasingly conceiving learning as a social activity, technological support must become more aware of the social context of the individual in order to be able to provide adequate support. But...

Taktstrasse (2008)

Schmidt, Andreas, Böttcher, Norman

Eine Taktstraße ermöglicht eine automatisierte Verarbeitung eines Werkstückes mit Hilfe von Förderbändern, Lichtschranken, Schiebern und Bearbeitungsstationen. Für eine vorgegebene Taktstraße...

Participatory development of a middleware for AAL solutions: requirements and approach – the case of SOPRANO (2008)

Balfanz, Dirk, Klein, Michael, Schmidt, Andreas, Santi, Marco

This paper describes the main features of a middleware for Ambient Assisted Living (AAL) applications, exemplified along the SOPRANO research project. The contribution outlines main requirements...

A.: People tagging & ontology maturing: Towards collaborative competence management (2008)

Andreas Schmidt, Simone Braun

Abstract. Competence Management approaches suggest promising instruments for more effective resource allocation, knowledge management, learning support, and human resource development in general....

Building updateable XML views on top of relational databases (2007)

Aleksei Valikov, Wassili Kazakos, Andreas Schmidt

In this paper we address the problem of adding XML interface to existing relational database solutions by providing mechanisms for storing, retrieving and querying information which resides in...

10.07.2002, kazakosUI2002_final.doc 1 Automation of Metadata Repository Development with XML Schema Abstract (2007)

Wassilios Kazakos, Alexei Valikov, Andreas Schmidt, Rainer Lehfeldt

Metadata standards have been discussed since years in the environmental domain. Although the community has agreed that metadata are important for information finding, an globally accepted standard is...

Im Wissensnetz: Linked Information Processes in Research Networks (2007)

Braun, Simone, Hefke, Mark, Schmidt, Andreas, Sevilmis, Neyir

At first glance, it seems to be quite surprising that so far traditional business process-oriented knowledge management techniques have not been transferred to research in order to improve the...

Hefke: “A Socially-Aware Desktop for e-Science: Supporting Learning (2007)

Simone Braun, Andreas Schmidt, Mark Hefke

Abstract. Research is likely to be the most knowledge-intensive environment, and it seems to be quite surprising that so far knowledge management (KM) techniques from business environments have not...

A.: Characterizing knowledge maturing: A conceptual process model for integrating e-learning and knowledge management (2007)

Ronald Maier, Andreas Schmidt

Abstract. Knowledge management and e-learning both attempt to support learning and knowledge transfer in organizations. However, they aim at knowledge of different degrees of maturity. Central...

A.: Wikis as a technology fostering knowledge maturing: What we can learn from wikipedia (2007)

Simone Braun, Andreas Schmidt

Abstract: The knowledge maturing theory opens an important macro perspective within the new paradigm of work-integrated learning. Especially wikis are interesting socio-technical systems to foster...

Ontology-Centred Design of an Ambient Middleware for Assisted Living: The Case of SOPRANO (2007)

Michael Klein, Andreas Schmidt, Rolf Lauer

Abstract. The aim of the EU-funded project SOPRANO is to assist older Europeans to lead a more independent life in their familiar environment by means of a next generation smart home with ambient...

BioMed Central (2007)

Bmc Bioinformatics, Jürgen Hartler, Gerhard G Thallinger, Gernot Stocker, Er Sturn, Thomas R Burkard, ...

Software MASPECTRAS: a platform for management and analysis of proteomics LC-MS/MS data

Agent-dysl: A novel intelligent reading system for dyslexic learners (2007)

Maria Athanasaki, Maria Avramouli, Kostas Karpouzis, Stefanos Kollias, Klimis Ntalianis, Andreas Schmidt, ...

Abstract: In this paper we present a novel approach for facilitating dyslexic children in learning to read fluently. We explain the motivation, general idea and initial results in terms of user...

Functional characterization of a novel Xenopus polo-like kinase interacting protein (2006)

Schmidt, Andreas

Summary Cell division is one of the most fundamental processes in biology. Meiosis is a specialized form of cell division resulting in cells capable of sexual reproduction. In higher animals male...

Functional characterization of a novel Xenopus polo-like kinase interacting protein (2006)

Schmidt, Andreas

Summary Cell division is one of the most fundamental processes in biology. Meiosis is a specialized form of cell division resulting in cells capable of sexual reproduction. In higher animals male...

Ontology-Based User Context Management: The Challenges of Imperfection and Time-Dependence (2006)

Andreas Schmidt

Robust and scalable user context management is the key enabler for the emerging context- and situation-aware applications, and ontology-based approaches have shown their usefulness for capturing...

Context-Aware Workplace Learning Support: (2006)

Concept Experiences And, Andreas Schmidt, Simone Braun

Workplace learning offers the unique possibility of the immediacy of purpose and real-world context. In order to leverage on this, we have developed a context-aware method to support workplace...

Towards a Human Resource Development Ontology (2006)

For Combining Competence, Andreas Schmidt, Christine Kunzmann, Kompetenzorientierte Personalentwicklung

Competencies as abstractions of work-relevant human behaviour have emerged as a promising concept for making human skills, knowledge and abilities manageable and addressable. On the organizational...

A layered model for user context management with controlled aging and imperfection handling (2006)

Andreas Schmidt

Abstract. Current research in context-awareness is biased toward low-level context information. High-level context information, however, poses several challenges to context management systems, which...

A.: Don’t Annoy the Informal Teacher – Context-Aware Mediation of Communication for Workplace (2006)

Simone Braun, Andreas Schmidt

Abstract: Verbal inter-human exchange forms an important part of informal learning, especially for workplace learning. But informal learning of an employee within inter-human communication implies...

Ontology-based Competence Management for Healthcare Training Planning: A Case Study (2006)

Christine Kunzmann, Andreas Schmidt

Abstract: With the increased pressure towards economic efficiency, hospitals and other healthcare institutions need to reengineer their internal organization and processes. This challenges human...

A layered model for user context management with controlled aging and imperfection handling (2006)

Andreas Schmidt

Abstract. Current research in context-awareness is biased toward low-level context information. High-level context information, however, poses several challenges to context management systems, which...

A Layered Model for User Context Management with Controlled Aging and Imperfection Handling (2005)

Andreas Schmidt

Current research in context-awareness is biased toward low-level context information. High-level context information, however, poses several challenges to context management systems, which can be...

Bridging the Gap between Knowledge Management and E-Learning with Context-Aware Corporate Learning (2005)

Andreas Schmidt

This paper proposes context awareness with respect to the learner's or employee's context as a solution to bridge the gap. The project Learning in Process is illustrating a step into that...

Knowledge Maturing and the Continuity of Context as a Unifying Concept for Knowledge Management and E-Learning (2005)

Andreas Schmidt

Abstract: Although both e-learning and knowledge management are about facilitating learning in organization, the major obstacle to bring both of them together can be traced back to different...

Bridging the gap between knowledge management and e-learning with contextaware corporate learning solutions (2005)

Andreas Schmidt

Knowledge management and e-learning both address the same fundamental problem: facilitating learning in organizations. But they approach the problem with two different paradigms, resulting in two...

Knowledge Maturing and the Continuity of Context as a Unifying Concept for Knowledge Management and E-Learning (2005)

Andreas Schmidt

Abstract: Although both e-learning and knowledge management are about facilitating learning in organization, the major obstacle to bring both of them together can be traced back to different...

Bridging the gap between knowledge management and e-learning with contextaware corporate learning solutions (2005)

Andreas Schmidt

Knowledge management and e-learning both address the same fundamental problem: facilitating learning in organizations. But they approach the problem with two different paradigms, resulting in two...

Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity (2005)

Schmidt, Andreas, Duncan, Peter I., Rauh, Nadine R., Sauer, Guido, Fry, Andrew M., Nigg, Erich A., ...

Metaphase-to-anaphase transition is a fundamental step in cell cycle progression where duplicated sister-chromatids segregate to the future daughter cells. The anaphase-promoting complex/cyclosome...

Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency (2004)

Schmidt, Andreas, Marescau, Bart, Boehm, Ernest A., Renema, W. Klaas Jan, Peco, Ruben, Das, Anib, ...

We generated a knockout mouse model for guanidinoacetate N-methyltransferase (GAMT) deficiency (MIM 601240), the first discovered human creatine deficiency syndrome, by gene targeting in embryonic...

C.: User context aware delivery of e-learning material: Approach and architecture (2004)

Andreas Schmidt, Claudia Winterhalter

Abstract: Current E-Learning solutions are not sufficiently aware of the context of the learner, that is the individual’s characteristics and the organizational context such as the work processes...

Context-steered Learning: The Learning in Process Approach (2004)

Andreas Schmidt

Context-steered learning in enterprises promises both from a learner point of view and from an organizational point of view higher learning efficiency and improved quality control. We present the...

Management of Dynamic and (2004)

Imperfect User Context, Andreas Schmidt

INTRODUCTION With the ever-increasing volume of accessible information and the advent of ubiquitous information access via mobile and wearable devices, the focus of information systems research has...

C.: User context aware delivery of e-learning material: Approach and architecture (2004)

Andreas Schmidt, Claudia Winterhalter

Abstract: Current E-Learning solutions are not sufficiently aware of the context of the learner, i.e. the individual characteristics, the organization and the work processes and tasks. This can be...

Andreas: Intelligent retrieval of digital resources by exploiting their semantic context (2004)

Gábor M. Surányi, Gábor Nagypál, Andreas Schmidt

Abstract. Although the first digital archives storing a huge number of resources came into existence years ago, they still lack effective retrieval methods. The most obvious example is the World Wide...

Severely altered guanidino compound levels, disturbed body weight homeostasis, and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency (2004)

Schmidt, Andreas, Marescau, Bart, Boehm, Ernest A., Renema, W. Klaas Jan, Peco, Ruben, Das, Anib, ...

We generated a knockout mouse model for guanidinoacetate N-methyltransferase (GAMT) deficiency (MIM 601240), the first discovered human creatine deficiency syndrome, by gene targeting in embryonic...

Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency (2004)

Schmidt, Andreas, Marescau, Bart, Boehm, Ernest A., Renema, W. Klaas Jan, Peco, Ruben, Das, Anib, ...

We generated a knockout mouse model for guanidinoacetate N-methyltransferase (GAMT) deficiency (MIM 601240), the first discovered human creatine deficiency syndrome, by gene targeting in embryonic...

Severely altered guanidino compound levels, disturbed body weight homeostasis, and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency (2004)

Schmidt, Andreas, Marescau, Bart, Boehm, Ernest A., Renema, W. Klaas Jan, Peco, Ruben, Das, Anib, ...

We generated a knockout mouse model for guanidinoacetate N-methyltransferase (GAMT) deficiency (MIM 601240), the first discovered human creatine deficiency syndrome, by gene targeting in embryonic...

User Context Aware Delivery of E-Learning Material: Approach and Architecture (2003)

Andreas Schmidt, Claudia Winterhalter

Current E-Learning solutions are not sufficiently aware of the context of the learner, i.e. the individual characteristics, the organization and the work processes and tasks. This can be achieved by...

Single-chain Tet transregulators (2003)

Krueger, Christel, Berens, Christian, Schmidt, Andreas, Schnappinger, Dirk, Hillen, Wolfgang

We demonstrate here that the Tet repressor (TetR), a dimeric allosterical regulatory protein, can be converted to a fully functional monomer when connected by a 29 amino acid linker. TetR‐based...

A Model-Transformer Architecture for Web Applications (2002)

Alexey Valikov, Alexei Akhounov, Andreas Schmidt, Forschungszentrum Informatik

Abstract. This paper proposes a web application-oriented modification of Model-View-Controller architecture, which allows generic implementations of the controller and the view. Proposed architecture...

XI³ - Towards an Integration Web (2002)

Wassili Kazakos, Gabor Nagypal, Andreas Schmidt, Peter Tomczyk

The World Wide Web with its distributed and decentralized architecture has become the biggest information system ever. But it is fragmented into countless information sources which are required in...

Hydroformylierung und Hydroaminomethylierung von ortho-Alkenylphenolen (2001)

Schmidt, Andreas

In der vorliegenden Arbeit werden verschiedene Tamdemhydroformylierungsreaktionen von ortho-Alkenylphenolen beschrieben. Mit diesen rhodiumkatalysierten Umsetzungen sind sowohl benzoanellierte...

METALICA: An Enhanced Meta Search Engine for Literature Catalogs (1999)

Bethina Schmitt, Andreas Schmidt

Today there is an increasing if not confusing number of services available for searching and acquiring literature. This makes it more and more difficult for a user to take advantage of these new...

METALICA: An Enhanced Meta Search Engine (1999)

For Literature Catalogs, Bethina Schmitt, Andreas Schmidt

Today there is an increasing if not confusing number of services available for searching and acquiring literature. This makes it more and more difficult for a user to take advantage of these new...

Spätergebnisse der Periostlappenplastik am oberen Sprunggelenk / (1997)

Schmidt, Andreas.

Thesis (doctoral)--Rheinische Friedrich-Wilhelms-Universität zu Bonn, 1997.

Trifluoracetylierung nucleophiler Doppelbindungen / (1996)

Schmidt, Andreas.

Thesis (doctoral)--Universität Stuttgart, 1996.

Schubert, Messe G-Dur ; Schumann, Requiem für Mignon (1992)

Schubert, Franz (música), Schumann, Robert (música), Konzertvereinigung Wiener Staasopernchor (voz), Bonney, Barbara (voz), Poschner, Brigitte (voz), ...

Nacido y muerto en Viena (1797-1828), Franz Schubert fue un compositor precoz que a los catorce años ya había creado sus primeros lieder. Alumno de Salieri en la escuela municipal de su ciudad...

[La flauta mágica] (1991)

Mozart, Wolfgang Amadeus (música), Schikaneder, Emanuel (libreto), Moll, Kurt (voz), Schmidt, Andreas (voz), Courtney, James (voz), Araiza, Francisco (voz), ...

Nacido en Salzburgo en 1756 y muerto en Viena en 1791, Wolfgang Amadeus Mozart es calificado por la crítica como el creador cumbre en la historia de la música. Mozart es autor de una obra extensa...

Einfluss der Arbeit auf Schwangerschaft, Geburt und Neugeborenes / (1934)

Schmidt, Andreas.

Thesis (doctoral)--Friedrich-Wilhelms-Universität zu Berlin, 1934.

7 [i.e. Seven] Symphonies [de Sergei Prokofiev]

Prokofiev, Sergei (música), Berliner Philharmoniker (ejecución Musical), Schmidt, Andreas (voz), Ozawa, Seiji (dir. Musical), Fanning, David (texto Del Folleto), Neef, Sigrid (texto Del Folleto), ...

Sergei Prokofiev (Sontzovka, Ucrania, 1891 – Moscú, Rusia, 1953), compositor y pianista que encabezó la escena musical rusa entre 1930 y 1950, cuya extensa y audaz obra atraviesa numerosos...

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins*S⃞

Trojer, Patrick, Zhang, Jin, Yonezawa, Masato, Schmidt, Andreas, Zheng, Haiyan, Jenuwein, Thomas, ...

The linker histone H1 generally participates in the establishment of chromatin structure. However, of the seven somatic H1 isotypes in humans some are also implicated in the regulation of local gene...

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

Pippig, Diana A., Hellmuth, Johannes C., Cui, Sheng, Kirchhofer, Axel, Lammens, Katja, Lammens, Alfred, ...

RIG-I and MDA5 sense cytoplasmic viral RNA and set-off a signal transduction cascade, leading to antiviral innate immune response. The third RIG-I-like receptor, LGP2, differentially regulates RIG-I-...

5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

Schmidt, Andreas, Schwerd, Tobias, Hamm, Wolfgang, Hellmuth, Johannes C., Cui, Sheng, Wenzel, Michael, ...

The ATPase retinoid acid-inducible gene (RIG)-I senses viral RNA in the cytoplasm of infected cells and subsequently activates cellular antiviral defense mechanisms. RIG-I recognizes molecular...