Buonanno, Andres, Edmondson, Diane G., Hayes, William P.
Myogenin, as well as other MyoD-related skeletal muscle-specific transcription factors, regulate a large number of skeletal muscle genes during myogenic differentiation. During later development,...
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
Garcia, Rolando A. G., Vasudevan, Kuzhalini, Buonanno, Andres
Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of their cognate tyrosine kinase receptors, ErbB 1–4. The subcellular...
Fiber-Type-Specific Transcription of the Troponin I Slow Gene Is Regulated by Multiple Elements
Calvo, Soledad, Venepally, Pratap, Cheng, Jun, Buonanno, Andres
The regulatory elements that restrict transcription of genes encoding contractile proteins specifically to either slow- or fast-twitch skeletal muscles are unknown. As an initial step towards...
Molecular Dissection of DNA Sequences and Factors Involved in Slow Muscle-Specific Transcription
Calvo, Soledad, Vullhorst, Detlef, Venepally, Pratap, Cheng, Jun, Karavanova, Irina, Buonanno, Andres
Transcription is a major regulatory mechanism for the generation of slow- and fast-twitch myofibers. We previously identified an upstream region of the slow TnI gene (slow upstream regulatory element...
Rana, Zaheer A, Gundersen, Kristian, Buonanno, Andres, Vullhorst, Detlef
Firing patterns typical of slow motor units activate genes for slow isoforms of contractile proteins, but it remains unclear if there is a distinct pathway for fast isoforms or if their expression...
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
Garcia, Rolando A. G., Vasudevan, Kuzhalini, Buonanno, Andres
Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of their cognate tyrosine kinase receptors, ErbB 1–4. The subcellular...
Fiber-Type-Specific Transcription of the Troponin I Slow Gene Is Regulated by Multiple Elements
Calvo, Soledad, Venepally, Pratap, Cheng, Jun, Buonanno, Andres
The regulatory elements that restrict transcription of genes encoding contractile proteins specifically to either slow- or fast-twitch skeletal muscles are unknown. As an initial step towards...
Molecular Dissection of DNA Sequences and Factors Involved in Slow Muscle-Specific Transcription
Calvo, Soledad, Vullhorst, Detlef, Venepally, Pratap, Cheng, Jun, Karavanova, Irina, Buonanno, Andres
Transcription is a major regulatory mechanism for the generation of slow- and fast-twitch myofibers. We previously identified an upstream region of the slow TnI gene (slow upstream regulatory element...
Rana, Zaheer A, Gundersen, Kristian, Buonanno, Andres, Vullhorst, Detlef
Firing patterns typical of slow motor units activate genes for slow isoforms of contractile proteins, but it remains unclear if there is a distinct pathway for fast isoforms or if their expression...
Lunde, Ida G, Ekmark, Merete, Rana, Zaheer A, Buonanno, Andres, Gundersen, Kristian
The effects of exercise on skeletal muscle are mediated by a coupling between muscle electrical activity and gene expression. Several activity correlates, such as intracellular Ca2+, hypoxia and...
Activity-dependent repression of muscle genes by NFAT
Rana, Zaheer A., Gundersen, Kristian, Buonanno, Andres
Adult skeletal muscles retain an adaptive capacity to switch between slow- and fast-twitch properties that largely depend on motoneuron activity. The NFAT (nuclear factor of activated T cells) family...
Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors
Kwon, Oh Bin, Paredes, Daniel, Gonzalez, Carmen M., Neddens, Jörg, Hernandez, Luis, Vullhorst, Detlef, ...
Neuregulin-1 (NRG-1) is genetically linked with schizophrenia, a neurodevelopmental cognitive disorder characterized by imbalances in glutamatergic and dopaminergic function. NRG-1 regulates numerous...
Neddens, Jörg, Vullhorst, Detlef, Paredes, Daniel, Buonanno, Andres
Neuregulin-1 (NRG-1) and its receptor ErbB4 are genetically associated with schizophrenia, a complex developmental disorder of high heritability but unknown etiology that has been proposed to result...