Impact of image segmentation on high-content screening data quality for SK-BR-3 cells (2007)
Hill, Andrew A, LaPan, Peter, Li, Yizheng, Haney, Steve
Abstract Background High content screening (HCS) is a powerful method for the exploration of cellular signalling and morphology that is rapidly being adopted in cancer research. HCS uses automated...
BMC Bioinformatics BioMed Central (2007)
Andrew A Hill, Peter Lapan, Yizheng Li, Steve Haney
Research article Impact of image segmentation on high-content screening data quality for SK-BR-3 cells
Baugh, L. Ryan, Hill, Andrew A., Claggett, Julia M., Hill-Harfe, Kate, Wen, Joanne C., Slonim, Donna K., ...
Maternal and zygotic activities of the homeodomain protein PAL-1 specify the identity and maintain the development of the multipotent C blastomere lineage in the C. elegans embryo. To identify PAL-1...
Baugh, L. Ryan, Wen, Joanne C., Hill, Andrew A., Slonim, Donna K., Brown, Eugene L., Hunter, Craig P.
Phenotypic robustness is evidenced when single-gene mutations do not result in an obvious phenotype. It has been suggested that such phenotypic stability results from 'buffering' activities of...
Baugh, L Ryan, Wen, Joanne C, Hill, Andrew A, Slonim, Donna K, Brown, Eugene L, Hunter, Craig P
Abstract Phenotypic robustness is evidenced when single-gene mutations do not result in an obvious phenotype. It has been suggested that such phenotypic stability results from 'buffering' activities...
Hill, Andrew A, Brown, Eugene L, Whitley, Maryann Z, Tucker-Kellogg, Greg, Hunter, Craig P, Slonim, Donna K
Abstract Background Affymetrix oligonucleotide arrays simultaneously measure the abundances of thousands of mRNAs in biological samples. Comparability of array results is necessary for the creation...
Wilson, S. Brian, Kent, Sally C., Horton, Heidi F., Hill, Andrew A., Bollyky, Paul L., Hafler, David A., ...
Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor...
Evaluation of normalization procedures for oligonucleotide array data based on spiked cRNA controls
Hill, Andrew A, Brown, Eugene L, Whitley, Maryann Z, Tucker-Kellogg, Greg, Hunter, Craig P, Slonim, Donna K
Baugh, L Ryan, Wen, Joanne C, Hill, Andrew A, Slonim, Donna K, Brown, Eugene L, Hunter, Craig P
To identify interactions among genes implicated in posterior patterning of the C. elegans embryo, synthetic lethality following RNA interference of 22 genes was measured in 15 mutant strains. A pair...
Wilson, S. Brian, Kent, Sally C., Horton, Heidi F., Hill, Andrew A., Bollyky, Paul L., Hafler, David A., ...
Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor...
Evaluation of normalization procedures for oligonucleotide array data based on spiked cRNA controls
Hill, Andrew A, Brown, Eugene L, Whitley, Maryann Z, Tucker-Kellogg, Greg, Hunter, Craig P, Slonim, Donna K
Baugh, L Ryan, Wen, Joanne C, Hill, Andrew A, Slonim, Donna K, Brown, Eugene L, Hunter, Craig P
To identify interactions among genes implicated in posterior patterning of the C. elegans embryo, synthetic lethality following RNA interference of 22 genes was measured in 15 mutant strains. A pair...
Yanai, Itai, Baugh, L Ryan, Smith, Jessica J, Roehrig, Casey, Shen-Orr, Shai S, Claggett, Julia M, ...
Biological networks are inherently modular, yet little is known about how modules are assembled to enable coordinated and complex functions. We used RNAi and time series, whole-genome microarray...