Scientific Commons: Andrew Alexander Somogyi

Risk Assessment and Communication Tools for Genotype Associations with Multifactorial Phenotypes: The Concept of "Edge Effect" and Cultivating an Ethical Bridge between Omics Innovations and Society (2009)

Ozdemir, Vural, Suarez-Kurtz, Guilherme, Stenne, Raphaelle, Somogyi, Andrew Alexander, Someya, Toshiyuki, Kayaalp, S. Oguz, ...

Risk Assessment and Communication Tools for Genotype Associations with Multifactorial Phenotypes: The Concept of "Edge Effect" and Cultivating an Ethical Bridge between Omics Innovations and Society (2009)

Ozdemir, Vural, Suarez-Kurtz, Guilherme, Stenne, Raphaelle, Somogyi, Andrew Alexander, Someya, Toshiyuki, Kayaalp, S. Oguz, ...

Hyperalgesia in Opioid-Managed Chronic Pain and Opioid-Dependent Patients (2009)

Hay, Justin Luke, White, Jason Mark, Bochner, Felix, Somogyi, Andrew Alexander, Semple, Timothy James, Rousefell, Bruce

Justin L. Hay, Jason M. White, Felix Bochner, Andrew A. Somogyi, Tim J. Semple, and Bruce Rounsefell

Hyperalgesia in Opioid-Managed Chronic Pain and Opioid-Dependent Patients (2009)

Hay, Justin Luke, White, Jason Mark, Bochner, Felix, Somogyi, Andrew Alexander, Semple, Timothy James, Rousefell, Bruce

Justin L. Hay, Jason M. White, Felix Bochner, Andrew A. Somogyi, Tim J. Semple, and Bruce Rounsefell

The acceptability, safety, and tolerability of methadone/naloxone in a 50:1 ratio (2009)

Bell, James, Shearer, James, Ryan, Anni, Graham, Robert, Korompay, Kristy, Rizzo, Suzanne, ...

The acceptability, safety, and tolerability of methadone/naloxone in a 50:1 ratio (2009)

Bell, James, Shearer, James, Ryan, Anni, Graham, Robert, Korompay, Kristy, Rizzo, Suzanne, ...

Enhanced Buprenorphine Analgesia with the Addition of Ultra-low-dose Naloxone in Healthy Subjects (2008)

La Vincente, Sophie F., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix, Chapleo, C B.

Animal studies have demonstrated that co-administration of an ultra-low-dose opioid antagonist with an opioid agonist may result in enhanced analgesia. Investigation of this effect in humans has been...

Enhanced Buprenorphine Analgesia with the Addition of Ultra-low-dose Naloxone in Healthy Subjects (2008)

La Vincente, Sophie F., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix, Chapleo, C B.

Animal studies have demonstrated that co-administration of an ultra-low-dose opioid antagonist with an opioid agonist may result in enhanced analgesia. Investigation of this effect in humans has been...

Role of active metabolites in the use of opioids (2008)

Coller, Janet Kristie, Christrup, L. L., Somogyi, Andrew Alexander

Janet K. Coller, Lona L. Christrup, Andrew A. Somogyi

Role of active metabolites in the use of opioids (2008)

Coller, Janet Kristie, Christrup, L. L., Somogyi, Andrew Alexander

Janet K. Coller, Lona L. Christrup, Andrew A. Somogyi

Antinociceptive effects of high dose remifentanil in male methadone-maintained patients (2008)

Hay, Justin Luke, White, Jason Mark, Bochner, Felix, Somogyi, Andrew Alexander

Antinociceptive effects of high dose remifentanil in male methadone-maintained patients (2008)

Hay, Justin Luke, White, Jason Mark, Bochner, Felix, Somogyi, Andrew Alexander

Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline (2008)

Davies, Benjamin James Lloyd, Herbert, Megan K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

The definitive version may be found at www.wiley.com

Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline (2008)

Davies, Benjamin James Lloyd, Herbert, Megan K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

The definitive version may be found at www.wiley.com

Flexible dosing of Tincture of Opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics (2008)

Somogyi, Andrew Alexander, Larsen, Mie, Abadi, Reza M., Jittiwutikarn, Jaroon, Ali, Robert Leonard, White, Jason Mark

Andrew A. Somogyi, Mie Larsen, Reza M. Abadi, Jaroon Jittiwutikarn, Robert Ali & Jason M. White

Flexible dosing of Tincture of Opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics (2008)

Somogyi, Andrew Alexander, Larsen, Mie, Abadi, Reza M., Jittiwutikarn, Jaroon, Ali, Robert Leonard, White, Jason Mark

Andrew A. Somogyi, Mie Larsen, Reza M. Abadi, Jaroon Jittiwutikarn, Robert Ali & Jason M. White

Response to "No influence of ABCB1 haplotypes on methadone dosage requirement" (2008)

Coller, Janet Kristie, Barratt, Daniel, Somogyi, Andrew Alexander

Response to "No influence of ABCB1 haplotypes on methadone dosage requirement" (2008)

Coller, Janet Kristie, Barratt, Daniel, Somogyi, Andrew Alexander

Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis (2008)

James, Heather M., Gillis, David, Hissaria, Pravin, Lester, Susan, Somogyi, Andrew Alexander, Cleland, Leslie Glen, ...

Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis (2008)

James, Heather M., Gillis, David, Hissaria, Pravin, Lester, Susan, Somogyi, Andrew Alexander, Cleland, Leslie Glen, ...

Evolution of Pharmacogenomics (2008)

Somogyi, Andrew Alexander

Evolution of Pharmacogenomics (2008)

Somogyi, Andrew Alexander

Lack of influence of CYP2D6 genotype on the clearance of (R)- (S)- and racemic-methadon (2007)

Coller, Janet Kristie, Joergensen, C., Foster, David John Richard, James, Heather M., Gillis, David, Christrup, L. L., ...

Objective: To investigate the influence of CYP2D6 genotype on the oral clearance of (R)-, (S)- and rac-methadone. Methods: In this retrospective study, CYP2D6 genotypes were identified in 56...

Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia (2007)

Inglis, Sally Catherine, Herbert, Megan K., Davies, Benjamin James Lloyd, Coller, Janet Kristie, James, Heather M., Horowitz, John David, ...

Sally C. Inglis; Megan K. Herbert; Benjamin J.L. Davies; Janet K. Coller; Heather M. James; John D. Horowitz; Raymond G. Morris; Robert W. Milne; Andrew A. Somogyi; Benedetta C. Sallustio

CYP2B6 CYP2D6 and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes (2007)

Davies, Benjamin James Lloyd, Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

Pharmacogenetics of opioids (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

Opioids are used for acute and chronic pain and dependency. They have a narrow therapeutic index and large interpatient variability in response. Genetic factors regulating their pharmacokinetics...

Lack of influence of CYP2D6 genotype on the clearance of (R)- (S)- and racemic-methadon (2007)

Coller, Janet Kristie, Joergensen, C., Foster, David John Richard, James, Heather M., Gillis, David, Christrup, L. L., ...

Objective: To investigate the influence of CYP2D6 genotype on the oral clearance of (R)-, (S)- and rac-methadone. Methods: In this retrospective study, CYP2D6 genotypes were identified in 56...

Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia (2007)

Inglis, Sally Catherine, Herbert, Megan K., Davies, Benjamin James Lloyd, Coller, Janet Kristie, James, Heather M., Horowitz, John David, ...

Sally C. Inglis; Megan K. Herbert; Benjamin J.L. Davies; Janet K. Coller; Heather M. James; John D. Horowitz; Raymond G. Morris; Robert W. Milne; Andrew A. Somogyi; Benedetta C. Sallustio

CYP2B6 CYP2D6 and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes (2007)

Davies, Benjamin James Lloyd, Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

Pharmacogenetics of opioids (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

Opioids are used for acute and chronic pain and dependency. They have a narrow therapeutic index and large interpatient variability in response. Genetic factors regulating their pharmacokinetics...

Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux (2007)

Igel, Svitlana, Drescher, S., Murdter, Thomas E., Hofmann, Ute, Heinkele, Georg, Nixon, J., ...

Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model (2007)

Jensen, M L., Foster, David John Richard, Upton, Richard Neil, Grant, Cliff, Martinez, Allison Marie, Somogyi, Andrew Alexander

M. L. Jensen; D. Foster; R. Upton; C. Grant; A. Martinez; A. Somogyi

Pharmacogenetics of opioids [dupe] (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux (2007)

Igel, Svitlana, Drescher, S., Murdter, Thomas E., Hofmann, Ute, Heinkele, Georg, Nixon, J., ...

Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model (2007)

Jensen, M L., Foster, David John Richard, Upton, Richard Neil, Grant, Clifford, Martinez, Allison Marie, Somogyi, Andrew Alexander

M. L. Jensen; D. Foster; R. Upton; C. Grant; A. Martinez; A. Somogyi

Pharmacogenetics of opioids [dupe] (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

Differential in vitro inhibition of M3G and M6G formation from morphine by (R)- and (S)-methadone and structurally related opioids (2006)

Morrish, G. A., Foster, D. J. R., Somogyi, Andrew Alexander

The definitive version is available at www.blackwell-synergy.com

Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation (2006)

Foster, D. J. R., Jensen, M. L., Upton, Richard Neil, Somogyi, Andrew Alexander, Grant, Cliff, Martinez, A.

Cerebral kinetics of oxycodone in conscious sheep (2006)

Villesen, H. H., Foster, D. J. R., Upton, Richard Neil, Somogyi, Andrew Alexander, Martinez, A., Grant, Cliff

Published in Journal of Pharmaceutical Sciences, 2006; 95 (8):1666-1676 at www.interscience.wiley.com

Blood-brain distribution of morphine-6-glucuronide in sheep (2006)

Villesen, H. H., Foster, D. J. R., Upton, Richard Neil, Christrup, L. L., Somogyi, Andrew Alexander, Martinez, A., ...

Background and purpose: At present there are few data regarding the rate and extent of brain–blood partitioning of the opioid active metabolite of morphine, morphine-6-glucuronide (M6G). In this...

Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography (2006)

Davies, B. J., Herbert, M. K., Culbert, J. A., Pyke, Simon Matthew, Coller, Janet Kristie, Somogyi, Andrew Alexander, ...

Methadone maintenance patients are cross-tolerant to the antinociceptive effects of very high plasma morphine concentrations (2006)

Athanasos, P., Smith, C. S., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix, Ling, W.

Association between the DRD2 A(1) allele and response to methadone and buprenorphine maintenance treatments (2006)

Barratt, Daniel, Somogyi, Andrew Alexander, Coller, Janet Kristie

The definitive version is available at www3.interscience.wiley.com.

Fluctuations in (R,S)-methadone pharmacokinetics and response among long-term methadone maintenance patients (2006)

Mitchell, T. B., Dyer, Kyle R., Newcombe, David, Somogyi, Andrew Alexander, White, Jason Mark

The definitive version is available at www.blackwell-synergy.com

Switching between methadone and morphine for maintenance treatment of opioid dependence: Impact on pain sensitivity and mood status (2006)

Mitchell, T. B., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix

This is an electronic version of an article published in American Journal on Addictions, 2006; 15 (4):311-315. American Journal on Addictions is available online at:...

Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: Application to a pharmacokinetic study in a methadone maintained subject (2006)

Foster, D. J. R., Morton, E. B., Heinkele, G., Murdter, T. E., Somogyi, Andrew Alexander

An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid (2006)

Polasek, T. M., Elliot, D. J., Somogyi, Andrew Alexander, Gillam, E. M. J., Lewis, B. C., Miners, J. O.

The definitive version is available at www.blackwell-synergy.com

Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography (2006)

Davies, B. J. L., Herbert, M. K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, R. W., Sallustio, B. C.

The use of perhexiline (PHX) is limited by hepatic and neurological toxicity associated with elevated concentrations in plasma that are the result of polymorphism of the cytochrome P450 2D6 isoform...

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals (2006)

Coller, Janet Kristie, Barratt, Daniel, Dahlen, K., Loennechen, M. H., Somogyi, Andrew Alexander

Background and Objectives: The most common treatment for opioid dependence is substitution therapy with another opioid such as methadone. The methadone dosage is individualized but highly variable,...

Differential in vitro inhibition of M3G and M6G formation from morphine by (R)- and (S)-methadone and structurally related opioids (2006)

Morrish, G. A., Foster, D. J. R., Somogyi, Andrew Alexander

The definitive version is available at www.blackwell-synergy.com

Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation (2006)

Foster, D. J. R., Jensen, M. L., Upton, Richard Neil, Somogyi, Andrew Alexander, Grant, Clifford, Martinez, A.

Cerebral kinetics of oxycodone in conscious sheep (2006)

Villesen, H. H., Foster, D. J. R., Upton, Richard Neil, Somogyi, Andrew Alexander, Martinez, A., Grant, Clifford

Published in Journal of Pharmaceutical Sciences, 2006; 95 (8):1666-1676 at www.interscience.wiley.com

Blood-brain distribution of morphine-6-glucuronide in sheep (2006)

Villesen, H. H., Foster, D. J. R., Upton, Richard Neil, Christrup, L. L., Somogyi, Andrew Alexander, Martinez, A., ...

Background and purpose: At present there are few data regarding the rate and extent of brain–blood partitioning of the opioid active metabolite of morphine, morphine-6-glucuronide (M6G). In this...

Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography (2006)

Davies, B. J., Herbert, M. K., Culbert, J. A., Pyke, Simon Matthew, Coller, Janet Kristie, Somogyi, Andrew Alexander, ...

Methadone maintenance patients are cross-tolerant to the antinociceptive effects of very high plasma morphine concentrations (2006)

Athanasos, P., Smith, C. S., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix, Ling, W.

Association between the DRD2 A(1) allele and response to methadone and buprenorphine maintenance treatments (2006)

Barratt, Daniel, Somogyi, Andrew Alexander, Coller, Janet Kristie

The definitive version is available at www3.interscience.wiley.com.

Fluctuations in (R,S)-methadone pharmacokinetics and response among long-term methadone maintenance patients (2006)

Mitchell, T. B., Dyer, Kyle R., Newcombe, David, Somogyi, Andrew Alexander, White, Jason Mark

The definitive version is available at www.blackwell-synergy.com

Switching between methadone and morphine for maintenance treatment of opioid dependence: Impact on pain sensitivity and mood status (2006)

Mitchell, T. B., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix

This is an electronic version of an article published in American Journal on Addictions, 2006; 15 (4):311-315. American Journal on Addictions is available online at:...

Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: Application to a pharmacokinetic study in a methadone maintained subject (2006)

Foster, D. J. R., Morton, E. B., Heinkele, G., Murdter, T. E., Somogyi, Andrew Alexander

An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid (2006)

Polasek, T. M., Elliot, D. J., Somogyi, Andrew Alexander, Gillam, E. M. J., Lewis, B. C., Miners, J. O.

The definitive version is available at www.blackwell-synergy.com

Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography (2006)

Davies, B. J. L., Herbert, M. K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, R. W., Sallustio, B. C.

The use of perhexiline (PHX) is limited by hepatic and neurological toxicity associated with elevated concentrations in plasma that are the result of polymorphism of the cytochrome P450 2D6 isoform...

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals (2006)

Coller, Janet Kristie, Barratt, Daniel, Dahlen, K., Loennechen, M. H., Somogyi, Andrew Alexander

Background and Objectives: The most common treatment for opioid dependence is substitution therapy with another opioid such as methadone. The methadone dosage is individualized but highly variable,...

The acute disposition of (R)- and (S)-methadone in brain and lung of sheep (2005)

Foster, D. J. R., Upton, Richard Neil, Somogyi, Andrew Alexander, Grant, C., Martinez, A. M.

The original publication is available at www.springerlink.com

Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids (2005)

Hutchinson, Mark R., Somogyi, Andrew Alexander

Opioids, such as morphine, can directly alter immune function via receptors expressed on immunocompetent cells. However, several studies have questioned the classical opioid nature of this change in...

Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects (2005)

Hanna, J., Foster, D. J. R., Salter, Amy Beatrix, Somogyi, Andrew Alexander, White, Jason Mark, Bochner, Felix

The definitive version is available at www.blackwell-synergy.com

The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia (2005)

Davies, B. J. L., Coller, Janet Kristie, James, H. M., Somogyi, Andrew Alexander, Horowitz, John David, Sallustio, B. C.

The definitive version is available at www.blackwell-synergy.com

The acute disposition of (R)- and (S)-methadone in brain and lung of sheep (2005)

Foster, D. J. R., Upton, Richard Neil, Somogyi, Andrew Alexander, Grant, C., Martinez, A. M.

The original publication is available at www.springerlink.com

Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids (2005)

Hutchinson, Mark R., Somogyi, Andrew Alexander

Opioids, such as morphine, can directly alter immune function via receptors expressed on immunocompetent cells. However, several studies have questioned the classical opioid nature of this change in...

Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects (2005)

Hanna, J., Foster, D. J. R., Salter, Amy Beatrix, Somogyi, Andrew Alexander, White, Jason Mark, Bochner, Felix

The definitive version is available at www.blackwell-synergy.com

The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia (2005)

Davies, B. J. L., Coller, Janet Kristie, James, H. M., Somogyi, Andrew Alexander, Horowitz, John David, Sallustio, B. C.

The definitive version is available at www.blackwell-synergy.com

Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence (2004)

Mitchell, T. B., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix

The definitive version is available at www.blackwell-synergy.com

Changes in methadone concentration, opiod effects, and opioid withdrawal during induction onto maintenance treatment (2004)

Athanasos, P., Morrish, G. A., Somogyi, Andrew Alexander, Bochner, Felix, White, Jason Mark

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes (2004)

Hutchinson, Mark R., Menelaou, A., Foster, D. J.R., Coller, Janet Kristie, Somogyi, Andrew Alexander

The definitive version is available at www.blackwell-synergy.com

Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre (2004)

Jittiwutikarn, J., Ali, Robert Leonard, White, Jason Mark, Bochner, Felix, Somogyi, Andrew Alexander, Foster, D. J.R.

The definitive version is available at www.blackwell-synergy.com

Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients (2004)

Foster, D. J.R., Somogyi, Andrew Alexander, White, Jason Mark, Bochner, Felix

The definitive version is available at www.blackwell-synergy.com.

Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure (2004)

Mitchell, T. B., Dyer, K. R., Newcombe, D. A. L., Salter, Amy Beatrix, Somogyi, Andrew Alexander, Bochner, Felix, ...

The definitive version is available at www.blackwell-synergy.com

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans (2004)

Glaeser, H., Drescher, S., Hofmann, U., Heinkele, G., Somogyi, Andrew Alexander, Eichelbaum, M., ...

Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis (2004)

Newcombe, D. A.L., Bochner, Felix, White, Jason Mark, Somogyi, Andrew Alexander

The aim of this study was to determine if substitution of daily methadone with second daily levo-alpha-acetylmethadol (LAAM) would convert non-holders on methadone into holders on LAAM, and to...

Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation (2004)

Hutchinson, Mark R., Somogyi, Andrew Alexander

(S)-(+)methadone is more immunosuppressive than the potent analgesic (R)-(-)-methadone (2004)

Hutchinson, Mark R., Somogyi, Andrew Alexander

Methadone is a widely used synthetic opioid which is administered as a racemic mixture of (R)-(−)- and (S)-(+)-enantiomers, with only (R)-(−)-methadone possessing μ opioid receptor agonist...

A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis (2004)

James, H. M., Coller, Janet Kristie, Gillis, D., Bahnisch, J., Sallustio, B. C., Somogyi, Andrew Alexander

In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance (2004)

Hutchinson, Mark R., Vincente, S. F. La, Somogyi, Andrew Alexander

CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement (2004)

Somogyi, Andrew Alexander, Menelaou, A., Fullston, S V.

Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence (2004)

Mitchell, T. B., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix

The definitive version is available at www.blackwell-synergy.com

Changes in methadone concentration, opiod effects, and opioid withdrawal during induction onto maintenance treatment (2004)

Athanasos, P., Morrish, G. A., Somogyi, Andrew Alexander, Bochner, Felix, White, Jason Mark

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes (2004)

Hutchinson, Mark R., Menelaou, A., Foster, D. J.R., Coller, Janet Kristie, Somogyi, Andrew Alexander

The definitive version is available at www.blackwell-synergy.com

Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre (2004)

Jittiwutikarn, J., Ali, Robert Leonard, White, Jason Mark, Bochner, Felix, Somogyi, Andrew Alexander, Foster, D. J.R.

The definitive version is available at www.blackwell-synergy.com

Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients (2004)

Foster, D. J.R., Somogyi, Andrew Alexander, White, Jason Mark, Bochner, Felix

The definitive version is available at www.blackwell-synergy.com.

Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure (2004)

Mitchell, T. B., Dyer, K. R., Newcombe, D. A. L., Salter, Amy Beatrix, Somogyi, Andrew Alexander, Bochner, Felix, ...

The definitive version is available at www.blackwell-synergy.com

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans (2004)

Glaeser, H., Drescher, S., Hofmann, U., Heinkele, G., Somogyi, Andrew Alexander, Eichelbaum, M., ...

Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis (2004)

Newcombe, D. A.L., Bochner, Felix, White, Jason Mark, Somogyi, Andrew Alexander

The aim of this study was to determine if substitution of daily methadone with second daily levo-alpha-acetylmethadol (LAAM) would convert non-holders on methadone into holders on LAAM, and to...

Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation (2004)

Hutchinson, Mark R., Somogyi, Andrew Alexander

(S)-(+)methadone is more immunosuppressive than the potent analgesic (R)-(-)-methadone (2004)

Hutchinson, Mark R., Somogyi, Andrew Alexander

Methadone is a widely used synthetic opioid which is administered as a racemic mixture of (R)-(−)- and (S)-(+)-enantiomers, with only (R)-(−)-methadone possessing μ opioid receptor agonist...

A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis (2004)

James, H. M., Coller, Janet Kristie, Gillis, D., Bahnisch, J., Sallustio, B. C., Somogyi, Andrew Alexander

In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance (2004)

Hutchinson, Mark R., Vincente, S. F. La, Somogyi, Andrew Alexander

CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement (2004)

Somogyi, Andrew Alexander, Menelaou, A., Fullston, S V.

Polymorphic hydroxylation of perhexiline in vitro (2003)

Sørensen, L. B., Sørensen, R. N., Miners, J. O., Somogyi, Andrew Alexander, Grgurinovich, N., Birkett, D. L.

The definitive version is available at www.blackwell-synergy.com

Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline (2003)

Davies, B. J.L., Coller, Janet Kristie, James, H. M., Gillis, D., Somogyi, Andrew Alexander, Horowitz, John David, ...

The definitive version is available at www.blackwell-synergy.com

Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence (2003)

Mitchell, T. B., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix

BACKGROUND: Slow-release oral morphine (SROM) has been proposed as an alternative maintenance pharmacotherapy to methadone for treatment of opioid dependence. However, the pharmacodynamics and...

Stereoselective drug metabolism and drug interactions (2003)

Gross, A., Somogyi, Andrew Alexander, Eichelbaum, M.

The original publication is available at www.springerlink.com

Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection (2003)

Menelaou, A., Hutchinson, Mark R., Quinn, I., Christensen, A., Somogyi, Andrew Alexander

High-performance liquid chromatographic assays for the O- and N-demethylated oxidative metabolites of hydrocodone and oxycodone formed in human liver microsomes are described. A solvent–solvent...

Polymorphic hydroxylation of perhexiline in vitro (2003)

Sørensen, L. B., Sørensen, R. N., Miners, J. O., Somogyi, Andrew Alexander, Grgurinovich, N., Birkett, D. L.

The definitive version is available at www.blackwell-synergy.com

Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline (2003)

Davies, B. J.L., Coller, Janet Kristie, James, H. M., Gillis, D., Somogyi, Andrew Alexander, Horowitz, John David, ...

The definitive version is available at www.blackwell-synergy.com

Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence (2003)

Mitchell, T. B., White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix

BACKGROUND: Slow-release oral morphine (SROM) has been proposed as an alternative maintenance pharmacotherapy to methadone for treatment of opioid dependence. However, the pharmacodynamics and...

Stereoselective drug metabolism and drug interactions (2003)

Gross, A., Somogyi, Andrew Alexander, Eichelbaum, M.

The original publication is available at www.springerlink.com

Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection (2003)

Menelaou, A., Hutchinson, Mark R., Quinn, I., Christensen, A., Somogyi, Andrew Alexander

High-performance liquid chromatographic assays for the O- and N-demethylated oxidative metabolites of hydrocodone and oxycodone formed in human liver microsomes are described. A solvent–solvent...

In vivo and in vitro potency studies of 6b-naltrexol, the major human metabolite of naltrexone (2002)

Porter, S. J., Somogyi, Andrew Alexander, White, Jason Mark

A phase I study of the GM-CSF antagonist E21R (2002)

Olver, I. N., Hercus, T., Lopez, A. F., Vadas, M. A., Somogyi, Andrew Alexander, Doyle, I. R., ...

The original publication is available at www.springerlink.com

Shed human enterocytes as a tool for the study of expression and function of intestinal drug-metabolizing enzymes and transporters (2002)

Glaeser, H., Drescher, S., Behrens, C., Geick, A., Burk, O., ...

Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies (2002)

Hutchinson, Mark R., Somogyi, Andrew Alexander

Reply to Dr. Clark's comment on Doverty et al., hyperalgesic responses in methadone maintenance patients (Pain 2001;90 : 91-96) (2002)

Doverty, Mark, White, Jason Mark, Somogyi, Andrew Alexander, Bochner, Felix, Ali, Robert Leonard, Ling, Walter

In vivo and in vitro potency studies of 6b-naltrexol, the major human metabolite of naltrexone (2002)