Williams, David R., Holton, Janice L., Strand, Catherine, Pittman, Alan, De Silva, Rohan, Lees, Andrew J., ...
Clinical syndromes associated with progressive supranuclear palsy-tau pathology now include progressive supranuclear palsy-parkinsonism (PSP-P), in addition to classic Richardson's syndrome (RS) and...
Paviour, Dominic C., Price, Shona L., Jahanshahi, Marjan, Lees, Andrew J., Fox, Nick C.
The rate of brain atrophy and its relationship to clinical disease progression in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is not clear. Twenty-four patients with PSP,...
Paviour, Dominic C., Price, Shona L., Jahanshahi, Marjan, Lees, Andrew J., Fox, Nick C.
The rate of brain atrophy and its relationship to clinical disease progression in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is not clear. Twenty-four patients with PSP,...
Khan, Naheed L., Jain, Shushant, Lynch, John M., Pavese, Nicola, Abou-Sleiman, Patrick, Holton, Janice L., ...
We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's...
Williams, David R., De Silva, Rohan, Paviour, Dominic C., Pittman, Alan, Watt, Hilary C., Kilford, Linda, ...
The clinical diagnosis of progressive supranuclear palsy (PSP) relies on the identification of characteristic signs and symptoms. A proportion of pathologically diagnosed cases do not develop these...
Pathophysiological differences between musician's dystonia and writer's cramp (2005)
Rosenkranz, Karin, Williamon, Aaron, Butler, Katherine, Cordivari, Carla, Lees, Andrew J., Rothwell, John C.
Focal hand dystonia (FHD) has been suggested to be a maladaptive response of the brain to repetitive performance of stereotyped and attentionally demanding hand movements. However, not all patients...
Serrien, Deborah J., Orth, Michael, Evans, Andrew H., Lees, Andrew J., Brown, Peter
There is considerable evidence that Gilles de la Tourette syndrome (TS) is due to frontal–striatal dysfunction. Here we determine whether adaptive cortical changes occur that might ameliorate the...
Pathophysiological differences between musician's dystonia and writer's cramp (2005)
Rosenkranz, Karin, Williamon, Aaron, Butler, Katherine, Cordivari, Carla, Lees, Andrew J., Rothwell, John C.
Summary Focal hand dystonia (FHD) has been suggested to be a maladaptive response of the brain to repetitive performance of stereotyped and attentionally demanding hand movements. However, not all...
Williams, David R., De Silva, Rohan, Paviour, Dominic C., Pittman, Alan, Watt, Hilary C., Kilford, Linda, ...
Summary The clinical diagnosis of progressive supranuclear palsy (PSP) relies on the identification of characteristic signs and symptoms. A proportion of pathologically diagnosed cases do not develop...
Khan, Naheed L., Jain, Shushant, Lynch, John M., Pavese, Nicola, Abou-Sleiman, Patrick, Holton, Janice L., ...
We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's...
Genome-wide analysis of the parkinsonism-dementia complex of Guam (2004)
Morris, Huw Rees, Steele, John C., Crook, Richard, Onstead-Cardinale, Luisa, Gwinn-Hardy, Katrina, ...
Genome-wide analysis of the parkinsonism-dementia complex of Guam (2004)
Morris, Huw Rees, Steele, John C., Crook, Richard, Onstead-Cardinale, Luisa, Gwinn-Hardy, Katrina, ...
Scherfler, Christoph, Khan, Naheed L., Pavese, Nicola, Eunson, Louise, Graham, Elizabeth, Lees, Andrew J., ...
To investigate striatal and cortical pre- and postsynaptic dopaminergic function in parkin-linked parkinsonism, 13 unrelated patients homozygous or compound heterozygous for parkin mutations were...
Ozawa, Tetsutaro, Paviour, Dominic, Quinn, Niall P., Josephs, Keith A., Sangha, Hardev, Kilford, Linda, ...
Summary Multiple system atrophy (MSA) has varying clinical (MSA-P versus MSA-C) and pathological [striatonigral degeneration (SND) versus olivopontocerebellar atrophy (OPCA)] phenotypes. To...
Serrien, Deborah J., Orth, Michael, Evans, Andrew H., Lees, Andrew J., Brown, Peter
Summary There is considerable evidence that Gilles de la Tourette syndrome (TS) is due to frontal-striatal dysfunction. Here we determine whether adaptive cortical changes occur that might ameliorate...
Scherfler, Christoph, Khan, Naheed L., Pavese, Nicola, Eunson, Louise, Graham, Elizabeth, Lees, Andrew J., ...
To investigate striatal and cortical pre‐ and postsynaptic dopaminergic function in parkin‐linked parkinsonism, 13 unrelated patients homozygous or compound heterozygous for parkin...
Ozawa, Tetsutaro, Paviour, Dominic, Quinn, Niall P., Josephs, Keith A., Sangha, Hardev, Kilford, Linda, ...
Multiple system atrophy (MSA) has varying clinical (MSA-P versus MSA-C) and pathological [striatonigral degeneration (SND) versus olivopontocerebellar atrophy (OPCA)] phenotypes. To investigate the...
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease (2004)
Bandopadhyay, Rina, Kingsbury, Ann E., Cookson, Mark R., Reid, Andrew R., Evans, Ian M., Hope, Andrew D., ...
Two mutations in the DJ‐1 gene on chromosome1p36 have been identified recently to cause early‐onset, autosomal recessive Parkinson’s disease. As no information is available regarding the...
Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity (2004)
Dale, Russell C., Church, Andrew J., Surtees, Robert A. H., Lees, Andrew J., Adcock, Jane E., Harding, Brian, ...
In 1916, von Economo first described encephalitis lethargica (EL), a CNS disorder presenting with pharyngitis followed by sleep disorder, basal ganglia signs (particularly parkinsonism) and...
Scherfler, Christoph, Khan, Naheed L., Pavese, Nicola, Eunson, Louise, Graham, Elizabeth, Lees, Andrew J., ...
To investigate striatal and cortical pre- and postsynaptic dopaminergic function in parkin-linked parkinsonism, 13 unrelated patients homozygous or compound heterozygous for parkin mutations were...
Ozawa, Tetsutaro, Paviour, Dominic, Quinn, Niall P., Josephs, Keith A., Sangha, Hardev, Kilford, Linda, ...
Summary Multiple system atrophy (MSA) has varying clinical (MSA-P versus MSA-C) and pathological [striatonigral degeneration (SND) versus olivopontocerebellar atrophy (OPCA)] phenotypes. To...
Serrien, Deborah J., Orth, Michael, Evans, Andrew H., Lees, Andrew J., Brown, Peter
Summary There is considerable evidence that Gilles de la Tourette syndrome (TS) is due to frontal-striatal dysfunction. Here we determine whether adaptive cortical changes occur that might ameliorate...
Parkin disease: a phenotypic study of a large case series (2003)
Khan, Naheed L., Graham, Elizabeth, Critchley, Peter, Schrag, Anette E, Wood, Nicholas W., Lees, Andrew J., ...
Mutations in the parkin gene, PARK2, are a common cause of parkinsonism in familial as well as isolated cases with an age of onset
Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity (2003)
Dale, Russell C., Church, Andrew J., Surtees, Robert A. H., Lees, Andrew J., Adcock, Jane E., Harding, Brian, ...
In 1916, von Economo first described encephalitis lethargica (EL), a CNS disorder presenting with pharyngitis followed by sleep disorder, basal ganglia signs (particularly parkinsonism) and...
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease (2003)
Bandopadhyay, Rina, Kingsbury, Ann E., Cookson, Mark R., Reid, Andrew R., Evans, Ian M., Hope, Andrew D., ...
Two mutations in the DJ-1 gene on chromosome1p36 have been identified recently to cause early-onset, autosomal recessive Parkinson’s disease. As no information is available regarding the...
Parkin disease: a phenotypic study of a large case series (2003)
Khan, Naheed L., Graham, Elizabeth, Critchley, Peter, Schrag, Anette E, Wood, Nicholas W., Lees, Andrew J., ...
Mutations in the parkin gene, PARK2, are a common cause of parkinsonism in familial as well as isolated cases with an age of onset
Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity (2003)
Dale, Russell C., Church, Andrew J., Surtees, Robert A. H., Lees, Andrew J., Adcock, Jane E., Harding, Brian, ...
In 1916, von Economo first described encephalitis lethargica (EL), a CNS disorder presenting with pharyngitis followed by sleep disorder, basal ganglia signs (particularly parkinsonism) and...
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease (2003)
Bandopadhyay, Rina, Kingsbury, Ann E., Cookson, Mark R., Reid, Andrew R., Evans, Ian M., Hope, Andrew D., ...
Two mutations in the DJ-1 gene on chromosome1p36 have been identified recently to cause early-onset, autosomal recessive Parkinson’s disease. As no information is available regarding the...
Reporting clinical trials: full access to all the data (2002)
Rosenberg, Roger N., Aminoff, Michael, Boller, Francois, Soerensen, Per Soelberg, Griggs, Robert C., Hachinski, Vladimir, ...
The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service (2002)
Hughes, Andrew J., Daniel, Susan E., Ben-Shlomo, Yoav, Lees, Andrew J.
We have reviewed the clinical and pathological diagnoses of 143 cases of parkinsonism seen by neurologists associated with the movement disorders service at The National Hospital for Neurology and...
Khan, Naheed L., Brooks, David J., Pavese, Nicola, Sweeney, Mary G., Wood, Nicholas W., Lees, Andrew J., ...
Molecular and clinical characterization of parkin‐associated parkinsonism is well described; however, there are no data available on progression of dopamine terminal dysfunction in...
A clinical and pathological study of motor neurone disease on Guam (2001)
Morris, Huw Rees, Al-Sarraj, S., Schwab, C., Gwinn-Hardy, Katrina, Perez-Tur, Jordi, Wood, Nick W., ...
A clinical and pathological study of motor neurone disease on Guam (2001)
Morris, Huw Rees, Al-Sarraj, S., Schwab, C., Gwinn-Hardy, Katrina, Perez-Tur, Jordi, Wood, Nick W., ...
Geddes, Jennian F., Hughes, Andrew J., Lees, Andrew J., Daniel, Susan E.
In recent years a number of patients suffering from long-standing postencephalitic parkinsonism have donated their brains to the United Kingdom Parkinson's Disease Society Brain Bank, in London. In...