Polyfunctional T cell responses are a hallmark of HIV-2 infection (2008)
Duvall, Melody G., Precopio, Melissa Lynn, Ambrozak, David A., Jaye, Assan, McMichael, Andrew J., Whittle, Hilton C., ...
HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4(+) T cell help in most infected subjects. Thus, HIV-2...
Simon, A. Katharina, Newsom-Davis, Tom, Frayne, Matthew E. F., Chen, Paul F.-T., McMichael, Andrew J., Screaton, Gavin R.
Carbohydrate antigens such as glycolipids and glycoproteins are over-expressed in a variety of cancers and have therefore been identified as ideal candidates for tumour vaccines. Detection of...
Schaft, Niels, Lankiewicz, Birgit, Drexhage, Joost, Berrevoets, Cor, Moss, Denis J., Levitsky, Victor, ...
EBV is associated with a broad range of malignancies. Adoptive immunotherapy of these tumors with EBV-specific CTL proved useful. We generated a panel of primary human T cells specific to various EBV...
Schaft, Niels, Lankiewicz, Birgit, Drexhage, Joost, Berrevoets, Cor, Moss, Denis J., Levitsky, Victor, ...
EBV is associated with a broad range of malignancies. Adoptive immunotherapy of these tumors with EBV-specific CTL proved useful. We generated a panel of primary human T cells specific to various EBV...
Structural and functional properties of the human Notch-1 ligand binding region (2004)
Hambleton, Sophie, Valeyev, Najl V., Muranyi, Andreas, Knott, Vroni, Werner, Jorn M., McMichael, Andrew J., ...
We present NMR structural and dynamics analysis of the putative ligand binding region of human Notch-1, comprising EGF-like domains 11–13. Functional integrity of an unglycosylated, recombinant...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection (2004)
Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, ...
HIV-1 infection induces activation and differentiation of CD8+ T-cells, resulting in replicative senescence. This may be part of the mechanism through which HIV-1 exhausts the capacity of the immune...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection (2004)
Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
Bird, Lucy A., Peh, Chen Au, Kollnberger, Simon, Elliott, Tim, McMichael, Andrew J., Bowness, Paul
The MHC class I allele HLA-B27 is very strongly associated with development of autoimmune spondyloarthritis, although the disease mechanism remains unknown. Class I molecules classically associate in...
J. Bruce Sundstrom, Kimberley C. Jollow, Veronique Braud, Francois Villinger, Andrew J. McMichael, E. Clinton Lawrence, ...
In this investigation we have explored the relationship between the weak allogenicity of cardiac myocytes and their capacity to present allo-antigens by examining the ability of a human cardiac...
J. Bruce Sundstrom, Kimberley C. Jollow, Veronique Braud, Francois Villinger, Andrew J. McMichael, E. Clinton Lawrence, ...
In this investigation we have explored the relationship between the weak allogenicity of cardiac myocytes and their capacity to present allo-antigens by examining the ability of a human cardiac...
Tan, Linda C, Mowat, Alastair G, Fazou, Chrysoula, Rostron, Tim, Roskell, Helen, Dunbar, P Rod, ...
Statement of findings CD8 + T cells dominate the lymphocyte population insynovial fluid in chronic inflammatory arthritis. It is known that theseCD8 + T cells are often clonally or oligoclonally...
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8 (1996)
W. Reid, Steve Mcadam, Kathrine J. Smith, Paul Klenerman, Chris A. O’callaghan, Karl Harlos, ...
In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend,
Huet, Stephane, Nixon, Douglas F., Rothbard, Jonathan B., Townsend, Alain, Ellis, Shirley A., McMichael, Andrew J.
Recently we described an HLA B27-restrlcted peptide derived from HIV gag p24 protein. In this study we have isolated an HLA B27-restrlcted peptide from the nucleoprotein (NP) of influenza A virus....
Progress in understanding HLA and disease associations (1987)
Batchelor, J Richard, McMichael, Andrew J
Since the previous review of the HLA system by the British Medical Bulletin in 1978 there have been remarkable advances in immunology and molecular biology. This has led to a more complete knowledge...
Tan, Linda C, Mowat, Alastair G, Fazou , Chrysoula, Rostron , Tim, Roskell, Helen, Dunbar , P Rod, ...
CD8+ T cells dominate the lymphocyte population in synovial fluid in chronic inflammatory arthritis. It is known that these CD8+ T cells are often clonally or oligoclonally expanded, but their...
Screaton, Gavin R., Xu, Xiao-Ning, Olsen, Anna L., Cowper, Alison E., Tan, Rusung, McMichael, Andrew J., ...
Fas and TNF-R1 are cysteine-rich cell surface receptors related to the low-affinity nerve growth factor receptor family. Engagement of these receptors by their respective ligands, FasL and tumor...
Antigen-Specific Expansion of Cytotoxic T Lymphocytes in Acute Measles Virus Infection
Mongkolsapaya, Juthathip, Jaye, Assan, Callan, Margaret F. C., Magnusen, Albert F., McMichael, Andrew J., Whittle, Hilton C.
Skewing of the T-cell receptor repertoire of CD8+ T cells has been shown in some persistent infections with viruses, such as human immunodeficiency virus, simian immunodeficiency virus, and...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Dorrell, Lucy, Dong, Tao, Ogg, Graham S., Lister, Simon, McAdam, Steve, Rostron, Tim, ...
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several...
Hanke, Tomas, Samuel, Rachel V., Blanchard, Tom J., Neumann, Veronica C., Allen, Todd M., Boyson, Jon E., ...
DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost...
Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...
CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...
Ogg, Graham S., Kostense, Stefan, Klein, Michel R., Jurriaans, Suzanne, Hamann, Dörte, McMichael, Andrew J., ...
Few studies have examined longitudinal changes in human immunodeficiency virus type 1 (HIV)-specific cytotoxic T lymphocytes (CTL). To more closely define the natural history of HIV-specific CTL, we...
Allen, Todd M., Jing, Peicheng, Calore, Briana, Horton, Helen, O'Connor, David H., Hanke, Tomas, ...
Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency...
Allergen-specific CD8+ T cells and atopic disease
Seneviratne, Suranjith L., Jones, Louise, King, Abigail S., Black, Antony, Powell, Sheila, McMichael, Andrew J., ...
Considerable evidence suggests that IL-10 may have a role in the manifestation of atopic disease. We sought to test the hypothesis that at the single cell level, allergen-specific T cells have...
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, Arnaud, Appay, Victor, Van Der Sande, Marianne, Dulphy, Nicolas, Liesnard, Corinne, Kidd, Michael, ...
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with...
Kaul, Rupert, Rowland-Jones, Sarah L., Kimani, Joshua, Dong, Tao, Yang, Hong-Bing, Kiama, Peter, ...
Resistance to HIV infection in a small group of Kenyan sex workers is associated with CD8+-lymphocyte responses to HIV cytotoxic T-lymphocyte (CTL) epitopes. Eleven prostitutes meeting criteria for...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Papagno, Laura, Spina, Celsa A, Marchant, Arnaud, Salio, Mariolina, Rufer, Nathalie, Little, Susan, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
CD8+ T-cell selection, function, and death in the primary immune response in vivo
Callan, Margaret F.C., Fazou, Chrysoula, Yang, Hongbing, Rostron, Tim, Poon, Kathryn, Hatton, Chris, ...
The primary immune response to Epstein Barr virus (EBV) is characterized by striking proliferation of EBV-specific CD8+ T cells. In this study we have investigated the clonal composition and...
Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells
Lucas, Michaela, Day, Cheryl L., Wyer, Jessica R., Cunliffe, Sharon L., Loughry, Andrew, McMichael, Andrew J., ...
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a...
Larke, Natasha, Murphy, Aileen, Wirblich, Christoph, Teoh, Denise, Estcourt, Marie J., McMichael, Andrew J., ...
In the absence of strategies for reliable induction of antibodies broadly neutralizing human immunodeficiency virus type 1 (HIV-1), vaccine efforts have shifted toward the induction of cell-mediated...
Goonetilleke, Nilu, Moore, Stephen, Dally, Len, Winstone, Nicola, Cebere, Inese, Mahmoud, Abdul, ...
A double-blind randomized phase I trial was conducted in human immunodeficiency virus type 1 (HIV-1)-negative subjects receiving vaccines vectored by plasmid DNA and modified vaccinia virus Ankara...
Tan, Linda C, Mowat, Alastair G, Fazou , Chrysoula, Rostron , Tim, Roskell, Helen, Dunbar , P Rod, ...
CD8+ T cells dominate the lymphocyte population in synovial fluid in chronic inflammatory arthritis. It is known that these CD8+ T cells are often clonally or oligoclonally expanded, but their...
Screaton, Gavin R., Xu, Xiao-Ning, Olsen, Anna L., Cowper, Alison E., Tan, Rusung, McMichael, Andrew J., ...
Fas and TNF-R1 are cysteine-rich cell surface receptors related to the low-affinity nerve growth factor receptor family. Engagement of these receptors by their respective ligands, FasL and tumor...
Antigen-Specific Expansion of Cytotoxic T Lymphocytes in Acute Measles Virus Infection
Mongkolsapaya, Juthathip, Jaye, Assan, Callan, Margaret F. C., Magnusen, Albert F., McMichael, Andrew J., Whittle, Hilton C.
Skewing of the T-cell receptor repertoire of CD8+ T cells has been shown in some persistent infections with viruses, such as human immunodeficiency virus, simian immunodeficiency virus, and...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Dorrell, Lucy, Dong, Tao, Ogg, Graham S., Lister, Simon, McAdam, Steve, Rostron, Tim, ...
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several...
Hanke, Tomas, Samuel, Rachel V., Blanchard, Tom J., Neumann, Veronica C., Allen, Todd M., Boyson, Jon E., ...
DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost...
Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...
CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...
Ogg, Graham S., Kostense, Stefan, Klein, Michel R., Jurriaans, Suzanne, Hamann, Dörte, McMichael, Andrew J., ...
Few studies have examined longitudinal changes in human immunodeficiency virus type 1 (HIV)-specific cytotoxic T lymphocytes (CTL). To more closely define the natural history of HIV-specific CTL, we...
Allen, Todd M., Jing, Peicheng, Calore, Briana, Horton, Helen, O'Connor, David H., Hanke, Tomas, ...
Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency...
Allergen-specific CD8+ T cells and atopic disease
Seneviratne, Suranjith L., Jones, Louise, King, Abigail S., Black, Antony, Powell, Sheila, McMichael, Andrew J., ...
Considerable evidence suggests that IL-10 may have a role in the manifestation of atopic disease. We sought to test the hypothesis that at the single cell level, allergen-specific T cells have...
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, Arnaud, Appay, Victor, Van Der Sande, Marianne, Dulphy, Nicolas, Liesnard, Corinne, Kidd, Michael, ...
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with...
Kaul, Rupert, Rowland-Jones, Sarah L., Kimani, Joshua, Dong, Tao, Yang, Hong-Bing, Kiama, Peter, ...
Resistance to HIV infection in a small group of Kenyan sex workers is associated with CD8+-lymphocyte responses to HIV cytotoxic T-lymphocyte (CTL) epitopes. Eleven prostitutes meeting criteria for...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Papagno, Laura, Spina, Celsa A, Marchant, Arnaud, Salio, Mariolina, Rufer, Nathalie, Little, Susan, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
CD8+ T-cell selection, function, and death in the primary immune response in vivo
Callan, Margaret F.C., Fazou, Chrysoula, Yang, Hongbing, Rostron, Tim, Poon, Kathryn, Hatton, Chris, ...
The primary immune response to Epstein Barr virus (EBV) is characterized by striking proliferation of EBV-specific CD8+ T cells. In this study we have investigated the clonal composition and...
Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells
Lucas, Michaela, Day, Cheryl L., Wyer, Jessica R., Cunliffe, Sharon L., Loughry, Andrew, McMichael, Andrew J., ...
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a...
Larke, Natasha, Murphy, Aileen, Wirblich, Christoph, Teoh, Denise, Estcourt, Marie J., McMichael, Andrew J., ...
In the absence of strategies for reliable induction of antibodies broadly neutralizing human immunodeficiency virus type 1 (HIV-1), vaccine efforts have shifted toward the induction of cell-mediated...
Goonetilleke, Nilu, Moore, Stephen, Dally, Len, Winstone, Nicola, Cebere, Inese, Mahmoud, Abdul, ...
A double-blind randomized phase I trial was conducted in human immunodeficiency virus type 1 (HIV-1)-negative subjects receiving vaccines vectored by plasmid DNA and modified vaccinia virus Ankara...
Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape
Karlsson, Annika C., Iversen, Astrid K.N., Chapman, Joan M., De Oliveira, Tulio, Spotts, Gerald, McMichael, Andrew J., ...
Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine
Létourneau, Sven, Im, Eung-Jun, Mashishi, Tumelo, Brereton, Choechoe, Bridgeman, Anne, Yang, Hongbing, ...
Increased frequencies of CD4+CD25high regulatory T cells in acute dengue infection
Lühn, Kerstin, Simmons, Cameron P., Moran, Edward, Dung, Nguyen Thi Phuong, Chau, Tran Nguyen Bich, Quyen, Nguyen Than Ha, ...
Dengue virus infection is an increasingly important tropical disease, causing 100 million cases each year. Symptoms range from mild febrile illness to severe hemorrhagic fever. The pathogenesis is...
Schneidewind, Arne, Brockman, Mark A., Yang, Ruifeng, Adam, Rahma I., Li, Bin, Le Gall, Sylvie, ...
Human leukocyte antigen (HLA)-B27-positive subjects are uncommon in their ability to control infection with human immunodeficiency virus type 1 (HIV-1). However, late viral escape from a narrowly...
T Cell Cross-Reactivity and Conformational Changes during TCR Engagement
Lee, Jean K., Stewart-Jones, Guillaume, Dong, Tao, Harlos, Karl, Di Gleria, Kati, Dorrell, Lucy, ...
All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in...
HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor
Dong, Tao, Stewart-Jones, Guillaume, Chen, Nan, Easterbrook, Philippa, Xu, Xiaoning, Papagno, Laura, ...
HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease...
Duvall, Melody G., Loré, Karin, Blaak, Hetty, Ambrozak, David A., Adams, William C., Santos, Kathlyn, ...
Human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) has been documented in vivo and may be an important contributor to HIV-1 transmission and pathogenesis. HIV-1-specific...
Sundstrom, J. Bruce, Jollow, Kimberley C., Braud, Veronique, Villinger, Francois, McMichael, Andrew J., Lawrence, E. Clinton, ...
In this investigation we have explored the relationship between the weak allogenicity of cardiac myocytes and their capacity to present allo-antigens by examining the ability of a human cardiac...
Amyes, Elisabeth, Hatton, Chris, Montamat-Sicotte, Damien, Gudgeon, Nancy, Rickinson, Alan B., McMichael, Andrew J., ...
The CD8+ T cell response to Epstein-Barr virus (EBV) is well characterized. Much less is known about the evolution of the CD4+ T cell response. Here we show that EBV stimulates a primary burst of...
HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Appay, Victor, Nixon, Douglas F., Donahoe, Sean M., Gillespie, Geraldine M.A., Dong, Tao, King, Abigail, ...
The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8+ T cells has provided a major development in our understanding of...
Allan, David S.J., Colonna, Marco, Lanier, Lewis L., Churakova, Tatyana D., Abrams, John S., Ellis, Shirley A., ...
The nonclassical MHC class I molecule human histocompatibility leukocyte antigen (HLA)-G is selectively expressed on fetal trophoblast tissue at the maternal–fetal interface in pregnancy. It has...
Xu, Xiao-Ning, Laffert, Bernd, Screaton, Gavin R., Kraft, Michael, Wolf, Dietlinde, Kolanus, Waldemar, ...
During HIV/SIV infection, there is widespread programmed cell death in infected and, perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas–Fas ligand (FasL)...
Kelleher, Anthony D., Long, Chad, Holmes, Edward C., Allen, Rachel L., Wilson, Jamie, Conlon, Christopher, ...
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263–272,...
Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8
Reid, Scott W., McAdam, Steve, Smith, Kathrine J., Klenerman, Paul, O'Callaghan, Chris A., Harlos, Karl, ...
In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J....
Xu, Xiao-Ning, Screaton, Gavin R., Gotch, Frances M., Dong, Tao, Tan, Rusung, Almond, Neil, ...
Inoculation of macaques with live attenuated SIV strains has been shown to protect against subsequent challenge with wild-type SIV. The protective mechanism(s) remain obscure. To study the effect in...
Rapid Effector Function in CD8+ Memory T Cells
Lalvani, Ajit, Brookes, Roger, Hambleton, Sophie, Britton, Warwick J., Hill, Adrian V.S., McMichael, Andrew J.
The nature of the CD8+ T cells that underlie antiviral protective immunological memory in vivo is unclear. We have characterized peptide-specific CD8+ T lymphocytes directly ex vivo from peripheral...
Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific
Wilson, Jamie D.K., Ogg, Graham S., Allen, Rachel L., Goulder, Philip J.R., Kelleher, Anthony, Sewell, Andy K., ...
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8+ T cells. These ‘expansions', which are...
Triple bypass: complicated paths to HIV escape
Human immunodeficiency virus (HIV) type 1 is highly efficient at evading immune responses and persisting, ultimately causing fatal immunodeficiency in some patients. Mutation in the epitopes...
Sundstrom, J. Bruce, Jollow, Kimberley C., Braud, Veronique, Villinger, Francois, McMichael, Andrew J., Lawrence, E. Clinton, ...
In this investigation we have explored the relationship between the weak allogenicity of cardiac myocytes and their capacity to present allo-antigens by examining the ability of a human cardiac...
Lee, Laurel Yong-Hwa, Ha, Do Lien Anh, Simmons, Cameron, De Jong, Menno D., Chau, Nguyen Van Vinh, Schumacher, Reto, ...
The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are...
Armitage, Andrew E., Katzourakis, Aris, De Oliveira, Tulio, Welch, John J., Belshaw, Robert, Bishop, Kate N., ...
The human polynucleotide cytidine deaminases APOBEC3G (hA3G) and APOBEC3F (hA3F) are antiviral restriction factors capable of inducing extensive plus-strand guanine-to-adenine (G-to-A) hypermutation...