Abstract Background Hypoxia-inducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia. To better understand the determinants of HIF-1 binding and transactivation, we used...
Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer (2009)
Migita, Toshiro, Ruiz, Stacey, Fornari, Alessandro, Fiorentino, Michelangelo, Priolo, Carmen, Zadra, Giorgia, ...
Background Overexpression of the fatty acid synthase (FASN) gene has been implicated in prostate carcinogenesis. We sought to directly assess the oncogenic potential of FASN. Methods We used...
Lee, Junghee, Hagerty, Sean, Cormier, Kerry A., Kim, Jinho, Kung, Andrew L., Ferrante, Robert J., ...
Chromatin remodeling is tightly controlled under physiological conditions. Alterations in chromatin structure are involved in the pathogenesis of neuronal systems. We found that the monoallelic...
Kimberly Stegmaier, Jenny S. Wong, Kenneth N. Ross, Kwan T. Chow, David Peck, Renee D. Wright, ...
BackgroundThe presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of...
A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas (2005)
Ken N. Ross, Matthew E. Wright, César Y. Hayashida, Sandro Santagata, Marta Barontini, ...
Pheochromocytomas are neural crest–derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP (2000)
Kung, Andrew L., Rebel, Vivienne I., Bronson, Roderick T., Ch'ng, Lian-Ee, Sieff, Colin A., Livingston, David M., ...
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 (1999)
Bhattacharya, Shoumo, Michels, Catherine L., Leung, Man-Kit, Arany, Zoltàn P., Kung, Andrew L., Livingston, David M.
Falvo, James V., Brinkman, Brigitta M. N., Tsytsykova, Alla V., Tsai, Eunice Y., Yao, Tso-Pang, Kung, Andrew L., ...
The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription through the integration of multiple signal transduction...
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
Freedman, Steven J., Sun, Zhen-Yu J., Poy, Florence, Kung, Andrew L., Livingston, David M., Wagner, Gerhard, ...
Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the...
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
Rebel, Vivienne I., Kung, Andrew L., Tanner, Elizabeth A., Yang, Hong, Bronson, Roderick T., Livingston, David M.
Hematopoietic stem cells (HSC) are tightly regulated through, as yet, undefined mechanisms that balance self-renewal and differentiation. We have identified a role for the transcriptional...
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
Rubin, Joshua B., Kung, Andrew L., Klein, Robyn S., Chan, Jennifer A., Sun, YanPing, Schmidt, Karl, ...
The vast majority of brain tumors in adults exhibit glial characteristics. Brain tumors in children are diverse: Many have neuronal characteristics, whereas others have glial features. Here we show...
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
Kung, Andrew L., Rebel, Vivienne I., Bronson, Roderick T., Ch'ng, Lian-Ee, Sieff, Colin A., Livingston, David M., ...
Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic...
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
Bhattacharya, Shoumo, Michels, Catherine L., Leung, Man-Kit, Arany, Zoltàn P., Kung, Andrew L., Livingston, David M.
Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 region and HIF-1α. A new...
p53 Targets Simian Virus 40 Large T Antigen for Acetylation by CBP
Poulin, Danielle L., Kung, Andrew L., DeCaprio, James A.
Simian virus 40 (SV40) large T antigen (T Ag) interacts with the tumor suppressor p53 and the transcriptional coactivators CBP and p300. Binding of these cellular proteins in a ternary complex has...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
Dahia, Patricia L. M, Ross, Ken N, Wright, Matthew E, Hayashida, César Y, Santagata, Sandro, Barontini, Marta, ...
Pheochromocytomas are neural crest–derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct...
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
Walensky, Loren D., Kung, Andrew L., Escher, Iris, Malia, Thomas J., Barbuto, Scott, Wright, Renee D., ...
BCL-2 family proteins constitute a critical control point for the regulation of apoptosis. Protein interaction between BCL-2 members is a prominent mechanism of control and is mediated through the...
Falvo, James V., Brinkman, Brigitta M. N., Tsytsykova, Alla V., Tsai, Eunice Y., Yao, Tso-Pang, Kung, Andrew L., ...
The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription through the integration of multiple signal transduction...
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
Freedman, Steven J., Sun, Zhen-Yu J., Poy, Florence, Kung, Andrew L., Livingston, David M., Wagner, Gerhard, ...
Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the...
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
Rebel, Vivienne I., Kung, Andrew L., Tanner, Elizabeth A., Yang, Hong, Bronson, Roderick T., Livingston, David M.
Hematopoietic stem cells (HSC) are tightly regulated through, as yet, undefined mechanisms that balance self-renewal and differentiation. We have identified a role for the transcriptional...
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
Rubin, Joshua B., Kung, Andrew L., Klein, Robyn S., Chan, Jennifer A., Sun, YanPing, Schmidt, Karl, ...
The vast majority of brain tumors in adults exhibit glial characteristics. Brain tumors in children are diverse: Many have neuronal characteristics, whereas others have glial features. Here we show...
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
Kung, Andrew L., Rebel, Vivienne I., Bronson, Roderick T., Ch'ng, Lian-Ee, Sieff, Colin A., Livingston, David M., ...
Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic...
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
Bhattacharya, Shoumo, Michels, Catherine L., Leung, Man-Kit, Arany, Zoltàn P., Kung, Andrew L., Livingston, David M.
Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 region and HIF-1α. A new...
p53 Targets Simian Virus 40 Large T Antigen for Acetylation by CBP
Poulin, Danielle L., Kung, Andrew L., DeCaprio, James A.
Simian virus 40 (SV40) large T antigen (T Ag) interacts with the tumor suppressor p53 and the transcriptional coactivators CBP and p300. Binding of these cellular proteins in a ternary complex has...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
Dahia, Patricia L. M, Ross, Ken N, Wright, Matthew E, Hayashida, César Y, Santagata, Sandro, Barontini, Marta, ...
Pheochromocytomas are neural crest–derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct...
A Novel Noninvasive Model of Endometriosis for Monitoring the Efficacy of Antiangiogenic Therapy
Becker, Christian M., Wright, Renee D., Satchi-Fainaro, Ronit, Funakoshi, Tae, Folkman, Judah, Kung, Andrew L., ...
Endometriosis, the presence of ectopic endometrial tissue, is a common disease associated with high morbidity and socioeconomic problems. Angiogenesis, the formation of new blood vessels, plays an...
Stegmaier, Kimberly, Wong, Jenny S, Ross, Kenneth N, Chow, Kwan T, Peck, David, Wright, Renee D, ...
Todd Golub and colleagues show that a gene expression-based screen of small-molecule libraries can identify candidate drugs that modulate cancer-associated oncoproteins.
Antimyeloma activity of heat shock protein-90 inhibition
Mitsiades, Constantine S., Mitsiades, Nicholas S., McMullan, Ciaran J., Poulaki, Vassiliki, Kung, Andrew L., Davies, Faith E., ...
We show that multiple myeloma (MM), the second most commonly diagnosed hematologic malignancy, is responsive to hsp90 inhibitors in vitro and in a clinically relevant orthotopic in vivo model, even...
Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias
Weisberg, Ellen, Catley, Laurie, Wright, Renee D., Moreno, Daisy, Banerji, Lolita, Ray, Arghya, ...
Drug resistance resulting from emergence of imatinib-resistant BCR-ABL point mutations is a significant problem in advanced-stage chronic myelogenous leukemia (CML). The BCR-ABL inhibitor, nilotinib...
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma
Alsayed, Yazan, Ngo, Hai, Runnels, Judith, Leleu, Xavier, Singha, Ujjal K., Pitsillides, Costas M., ...
The mechanisms by which multiple myeloma (MM) cells migrate and home to the bone marrow are not well understood. In this study, we sought to determine the effect of the chemokine SDF-1 (CXCL12) and...
Ziegler, David S., Wright, Renee D., Kesari, Santosh, Lemieux, Madeleine E., Tran, Mary A., Jain, Monish, ...
Multiple receptor tyrosine kinases (RTKs), including PDGFR, have been validated as therapeutic targets in glioblastoma multiforme (GBM), yet inhibitors of RTKs have had limited clinical success. As...
Glioblastoma Inhibition by Cell Surface Immunoglobulin Protein EWI-2, In Vitro and In Vivo1,2
Kolesnikova, Tatiana V, Kazarov, Alexander R, Lemieux, Madeleine E, Lafleur, Marc A, Kesari, Santosh, Kung, Andrew L, ...
EWI-2, a cell surface IgSF protein, is highly expressed in normal human brain but is considerably diminished in glioblastoma tumors and cell lines. Moreover, loss of EWI-2 expression correlated with...
Hahn, Cynthia K., Ross, Kenneth N., Warrington, Ian M., Mazitschek, Ralph, Kanegai, Cindy M., Wright, Renee D., ...
The discovery of new small molecules and their testing in rational combination poses an ongoing problem for rare diseases, in particular, for pediatric cancers such as neuroblastoma. Despite maximal...
Weisberg, Ellen, Banerji, Lolita, Wright, Renee D., Barrett, Rosemary, Ray, Arghya, Moreno, Daisy, ...
Mediators of PI3K/AKT signaling have been implicated in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Studies have shown that inhibitors of PI3K/AKT signaling, such as wortmannin...
Identification of AML1-ETO modulators by chemical genomics
Corsello, Steven M., Roti, Giovanni, Ross, Kenneth N., Chow, Kwan T., Galinsky, Ilene, DeAngelo, Daniel J., ...
Somatic rearrangements of transcription factors are common abnormalities in the acute leukemias. With rare exception, however, the resultant protein products have remained largely intractable as...
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
Kim, William Y., Perera, Samanthi, Zhou, Bing, Carretero, Julian, Yeh, Jen Jen, Heathcote, Samuel A., ...
Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia. In non–small cell lung cancer (NSCLC), high HIF2α levels correlate with...
Lipocalin 2 promotes breast cancer progression
Yang, Jiang, Bielenberg, Diane R., Rodig, Scott J., Doiron, Robert, Clifton, Matthew C., Kung, Andrew L., ...
Here, we report that lipocalin 2 (Lcn2) promotes breast cancer progression, and we identify the mechanisms underlying this function. We first found that Lcn2 levels were consistently associated with...
Xia, Xiaobo, Lemieux, Madeleine E., Li, Wei, Carroll, Jason S., Brown, Myles, Liu, X. Shirley, ...
Adaptation to hypoxia is mediated through a coordinated transcriptional response driven largely by hypoxia-inducible factor 1 (HIF-1). We used ChIP-chip and gene expression profiling to identify...