ABO Blood Group and the Risk of Pancreatic Cancer (2009)
Wolpin, Brian M., Chan, Andrew T., Hartge, Patricia, Chanock, Stephen J., Kraft, Peter, Hunter, David J., ...
Background Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in...
Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, ...
Abstract Background Cyclooxygenase-2 (COX-2, PTGS2 ) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite...
Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk (2008)
Berndt, Sonja I., Potter, John D., Hazra, Aditi, Yeager, Meredith, Thomas, Gilles, Makar, Karen W., ...
Several different genetic variants at chromosome 8q24 have been related to prostate, breast and colorectal cancer risk with evidence of region-specific risk differentials for various tumor types. We...
A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer (2008)
Ogino, Shuji, Nosho, Katsuhiko, Kirkner, Gregory J., Kawasaki, Takako, Chan, Andrew T., Schernhammer, Eva S., ...
Genome-wide DNA hypomethylation plays has an important role in genomic instability and colorectal carcinogenesis. However, the relationship between cellular DNA methylation level and patient outcome...
Dietary Choline and Betaine and the Risk of Distal Colorectal Adenoma in Women (2007)
Cho, Eunyoung, Willett, Walter C., Colditz, Graham A., Fuchs, Charles S., Wu, Kana, Chan, Andrew T., ...
Background Choline and betaine are involved in methyl-group metabolism as methyl-group donors; thus, like folate, another methyl-group donor, they may be associated with a reduced risk of colorectal...
Genetic Variants in the UGT1A6 Enzyme, Aspirin Use, and the Risk of Colorectal Adenoma (2005)
Chan, Andrew T., Tranah, Gregory J., Giovannucci, Edward L., Hunter, David J., Fuchs, Charles S.
Genetic variation in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) enzyme is associated with impaired metabolism of aspirin. To determine whether polymorphisms in the UGT1A6 enzyme...
Chan, Andrew T., Ma, Jing, Tranah, Gregory J., Giovannucci, Edward L., Rifai, Nader, Hunter, David J., ...
Background: Some experimental evidence suggests that iron may play a role in colorectal carcinogenesis, but human data for this role have been conflicting, possibly because of problems related to...
A Prospective Study of Aspirin Use and the Risk of Pancreatic Cancer in Women (2004)
Schernhammer, Eva S., Kang, Jae-Hee, Chan, Andrew T., Michaud, Dominique S., Skinner, Halcyon G., Giovannucci, Edward, ...
Background: In vitro experiments and limited animal studies suggest that aspirin and nonsteroidal anti-inflammatory drugs may inhibit pancreatic carcinogenesis. Because few studies have examined the...
Chan, Andrew T., Harvard Medical School.
Thesis (M.D. with honors)--Harvard Medical School, 1997.