Angel Luis Armesilla

In vitro evaluation of cancer-specific NF-kappaB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines. (2007)

Guo, X., Evans, T.R.J., Somanath, S., Armesilla, Angel Luis, Darling, John L., Schatzlein, A., ...

Nuclear factor-kappa B (NF-kappaB) is a transcription factor with high transcriptional activity in cancer cells. In this study, we developed a novel enhancer-promoter system, kappaB4-CEA205, in which...

The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells (2007)

Holton, Marylouisa, Yang, Di, Wang, Weiguang, Mohamed, Tamer M. A., Neyses, Ludwig, Armesilla, Angel Luis

Plasma membrane calcium/calmodulin-dependent ATPases (PMCAs) are high affinity calcium pumps that extrude calcium from the cell. Emerging evidence suggests a novel role for PMCAs as regulators of...

The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex. (2006)

Williams, Judith C., Armesilla, Angel Luis, Mohamed, Tamer M. A., Hagarty, Cassandra L., McIntyre, Fiona H., Schomburg, Sybille, ...

The main role of the plasma membrane Ca2+/calmodulin-dependent ATPase (PMCA) is in the removal of Ca2+ from the cytosol. Recently, we and others have suggested a new function for PMCA as a modulator...

The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit. (2005)

Buch, Mamta H., Pickard, Adam, Rodriguez, Antonio, Gillies, Sheona, Maass, Alexander H., Emerson, Michael, ...

The calcineurin/nuclear factor of activated T-cell (NFAT) pathway represents a crucial transducer of cellular function. There is increasing evidence placing the sarcolemmal calcium pump, or plasma...

Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. (2004)

Schuh, Kai, Cartwright, Elizabeth J., Jankevics, Eriks, Bundschu, Karin, Liebermann, Jürgen, Williams, Judith C., ...

Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely...

Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). (2004)

Armesilla, Angel Luis, Williams, Judith C., Buch, Mamta H., Pickard, Adam, Emerson, Michael, Cartwright, Elizabeth J., ...

Plasma membrane calmodulin-dependent calcium ATPases (PMCAs) are enzymatic systems implicated in the extrusion of calcium from the cell. We and others have previously identified molecular...

P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation. (2003)

Yague, Ernesto, Armesilla, Angel Luis, Harrison, Georgina, Elliott, James, Sardini, Alessandro, Higgins, Christopher F., ...

Multidrug resistance in acute myeloid leukemia is often conferred by overexpression of P-glycoprotein, encoded by the MDR1 gene. We have characterized the key regulatory steps in the development of...

Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression. (1999)

Armesilla, Angel Luis, Lorenzo, Elisa, Gómez Del Arco, Pablo, Martínez-Martínez, Sara, Alfranca, Arantzazu, Redondo, Juan Miguel

Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation. Here we show that...

The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. (1998)

Lara-Pezzi, Enrique, Armesilla, Angel Luis, Majano, Pedro L., Redondo, Juan Miguel, López-Cabrera, Manuel

The X gene product of the human hepatitis B virus (HBx) is a transcriptional activator of various viral and cellular genes. We recently have determined that the production of tumor necrosis...

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. (1997)

Martínez-Martínez, Sara, Gómez Del Arco, Pablo, Armesilla, Angel Luis, Aramburu, Jose, Luo, Chun, Rao, Anjana, ...

Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene...

JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes. (1996)

Gómez Del Arco, Pablo, Martínez-Martínez, Sara, Calvo, Victor, Armesilla, Angel Luis, Redondo, Juan Miguel

AP-1 has been shown to behave as a redox-sensitive transcription factor that can be activated by both oxidant and antioxidant stimuli. However, the mechanisms involved in the activation of AP-1 by...

Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site. (1996)

Armesilla, Angel Luis, Calvo, Dominica, Vega, Miguel A.

CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic...

Granulocyte-macrophage colony-stimulating factor, phorbol ester, and sodium butyrate induce the CD11c integrin gene promoter activity during myeloid cell differentiation. (1995)

Rubio, M.A., Lopez-Rodriguez, C., Nueda, A., Aller, P., Armesilla, Angel Luis, Vega, Miguel A., ...

To analyze the activity of the CD11c promoter during myeloid differentiation without the limitations of transient expression systems, we have stably transfected the myeloid U937 cell line with the...

Structural organization of the gene for human CD36 glycoprotein. (1994)

Armesilla, Angel Luis, Vega, Miguel A.

The cell-surface glycoprotein CD36 interacts with a large variety of ligands, including collagen types I and IV, thrombospondin, erythrocytes parasitized with Plasmodium falciparum,...

Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. (1993)

Fernández-Ruiz, Elena, Armesilla, Angel Luis, Sánchez-Madrid, Francisco, Vega, Miguel A.

The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin. CD36 also binds to red blood cells infected with...

Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression

Armesilla, Angel Luis, Lorenzo, Elisa, Gómez Del Arco, Pablo, Martínez-Martínez, Sara, Alfranca, Arantzazu, Redondo, Juan Miguel

Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation. Here we show that...

Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression

Armesilla, Angel Luis, Lorenzo, Elisa, Gómez Del Arco, Pablo, Martínez-Martínez, Sara, Alfranca, Arantzazu, Redondo, Juan Miguel

Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation. Here we show that...