Ben-Nathan, David, Gershoni-Yahalom, Orly, Samina, Itzchak, Khinich, Yevgeny, Nur, Israel, Laub, Orgad, ...
Abstract Background West Nile Virus (WNV) is endemic in Israel and a significant level of antibodies is present in the population due to natural exposure. Anecdotal cases suggested that the presence...
Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy (2008)
Arnon, Tal I., Markel, Gal, Bar-Ilan, Ahuva, Hanna, Jacob, Fima, Eyal, Benchetrit, Fabrice, ...
The natural cytotoxic receptors (NCRs) are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The NCRs, which include three members; NKp46, NKp44 and...
Hershkovitz, Oren, Jarahian, Mostafa, Zilka, Alon, Bar-Ilan, Ahuva, Landau, Guy, Jivov, Sergey, ...
NKp30 is a natural cytotoxicity receptor expressed by human NK cells and involved in NK lytic activity. We previously published that membranal heparan sulfate serves as a coligand for human NKp30. In...
Qimron,Udi, Madar,Neta, Mittrucker,Hans-Willi, Zilka,Alon, Yosef,Ido, Bloushtain,Noga, ...
Salmonella-derived epitopes are presented on MHC molecules by antigen-presenting cells, and both CD4+ and CD8+ T cells participate in protective immunity to Salmonella. Therefore, mechanisms that...
Day, Patricia M., Yewdell, Jonathan W., Porgador, Angel, Germain, Ronald N., Bennink, Jack R.
After brief incubation of cells with fluorescein-conjugated peptides that bind major histocompatibility complex (MHC) class I molecules, peptides were detected within the endoplasmic reticulum (ER)...
Porgador, Angel, Mandelboim, Ofer, Restifo, Nicholas P., Strominger, Jack L.
Cancer vaccines used to generate specific cytotoxic T lymphocytes are not effective against tumor cells that have lost or suppressed expression of their class I major histocompatibility complex...
Porgador, Angel, Staats, Herman F., Itoh, Yasushi, Kelsall, Brian L.
We previously reported that cholera toxin (CT) was required as a mucosal adjuvant for the induction of peptide-specific cytotoxic T lymphocytes (CTL) following intranasal immunization with CTL...
Novel APC-like properties of human NK cells directly regulate T cell activation
Hanna, Jacob, Gonen-Gross, Tsufit, Fitchett, Jonathan, Rowe, Tony, Daniels, Mark, Arnon, Tal I., ...
Initiation of the adaptive immune response is dependent on the priming of naive T cells by APCs. Proteomic analysis of unactivated and activated human NK cell membrane–enriched fractions...
Day, Patricia M., Yewdell, Jonathan W., Porgador, Angel, Germain, Ronald N., Bennink, Jack R.
After brief incubation of cells with fluorescein-conjugated peptides that bind major histocompatibility complex (MHC) class I molecules, peptides were detected within the endoplasmic reticulum (ER)...
Porgador, Angel, Mandelboim, Ofer, Restifo, Nicholas P., Strominger, Jack L.
Cancer vaccines used to generate specific cytotoxic T lymphocytes are not effective against tumor cells that have lost or suppressed expression of their class I major histocompatibility complex...
Porgador, Angel, Staats, Herman F., Itoh, Yasushi, Kelsall, Brian L.
We previously reported that cholera toxin (CT) was required as a mucosal adjuvant for the induction of peptide-specific cytotoxic T lymphocytes (CTL) following intranasal immunization with CTL...
Novel APC-like properties of human NK cells directly regulate T cell activation
Hanna, Jacob, Gonen-Gross, Tsufit, Fitchett, Jonathan, Rowe, Tony, Daniels, Mark, Arnon, Tal I., ...
Initiation of the adaptive immune response is dependent on the priming of naive T cells by APCs. Proteomic analysis of unactivated and activated human NK cell membrane–enriched fractions...
Rapid Chromatic Detection of Bacteria by Use of a New Biomimetic Polymer Sensor▿ †
Silbert, Liron, Ben Shlush, Izek, Israel, Elena, Porgador, Angel, Kolusheva, Sofiya, Jelinek, Raz
We present a new platform for visual and spectroscopic detection of bacteria. The detection scheme is based on the interaction of membrane-active compounds secreted by bacteria with agar-embedded...
CD100 on NK Cells Enhance IFNγ Secretion and Killing of Target Cells Expressing CD72
Mizrahi, Sa'ar, Markel, Gal, Porgador, Angel, Bushkin, Yuri, Mandelboim, Ofer
Porgador, Angel, Irvine, Kari R., Iwasaki, Akiko, Barber, Brian H., Restifo, Nicholas P., Germain, Ronald N.
Cutaneous gene (DNA) bombardment results in substantial expression of the encoded antigen in the epidermal layer as well as detectable expression in dendritic cells (DC) in draining lymph nodes...
Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy
Arnon, Tal I., Markel, Gal, Bar-Ilan, Ahuva, Hanna, Jacob, Fima, Eyal, Benchetrit, Fabrice, ...
The natural cytotoxic receptors (NCRs) are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The NCRs, which include three members; NKp46, NKp44 and...
Ho, Joanna W., Hershkovitz, Oren, Peiris, Malik, Zilka, Alon, Bar-Ilan, Ahuva, Nal, Beatrice, ...
Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by...
Hershkovitz, Oren, Zilka, Alon, Bar-Ilan, Ahuva, Abutbul, Shai, Davidson, Andrew, Mazzon, Michela, ...
Many viruses escape the cellular immune response by downregulating cell surface expression of major histocompatibility complex (MHC) class I molecules. However, infection of cells with flaviviruses...
Ben-Nathan, David, Gershoni-Yahalom, Orly, Samina, Itzchak, Khinich, Yevgeny, Nur, Israel, Laub, Orgad, ...
Cell type-specific DNA methylation patterns in the human breast
Bloushtain-Qimron, Noga, Yao, Jun, Snyder, Eric L., Shipitsin, Michail, Campbell, Lauren L., Mani, Sendurai A., ...
Cellular identity and differentiation are determined by epigenetic programs. The characteristics of these programs in normal human mammary epithelium and their similarity to those in stem cells are...