Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells (2008)
Kandert, Sebastian, Lüke, Yvonne, Kleinhenz, Tobias, Neumann, Sascha, Lu, Wenshu, Jaeger, Verena M., ...
Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells (2007)
Kandert, Sebastian, Lüke, Yvonne, Kleinhenz, Tobias, Neumann, Sascha, Lu, Wenshu, Jaeger, Verena M., ...
The S143F lamin A/C point mutation causes a phenotype combining features of myopathy and progeria. We demonstrate here that patient dermal fibroblast cells have dysmorphic nuclei containing numerous...
GxcDD, a putative RacGEF, is involved in Dictyosteliumdevelopment (2007)
Mondal, Subhanjan, Neelamegan, Dhamodharan, Rivero, Francisco, Noegel, Angelika A
Abstract Background Rho subfamily GTPases are implicated in a large number of actin-related processes. They shuttle from an inactive GDP-bound form to an active GTP-bound form. This reaction is...
GrlJ, a DictyosteliumGABAB-like receptor with roles in post-aggregation development (2007)
Prabhu, Yogikala, Müller, Rolf, Anjard, Christophe, Noegel, Angelika A
Abstract Background The G-protein-coupled receptor (GPCR) family represents the largest and most important group of targets for chemotherapeutics. They are extremely versatile receptors that...
Coronin 3 involvement in F-actin-dependent processes at the cell cortex (2007)
Rosentreter, Andre, Hofmann, Andreas, Xavier, Charles-Peter, Stumpf, Maria, Noegel, Angelika A., Clemen, Christoph S.
Yes
Coronin 3 involvement in F-actin-dependent processes at the cell cortex (2007)
Rosentreter, Andre, Hofmann, Andreas, Xavier, Charles-Peter, Stumpf, Maria, Noegel, Angelika A., Clemen, Christoph S.
Yes
Coronin 3 involvement in F-actin-dependent processes at the cell cortex (2007)
Rosentreter, Andre, Hofmann, Andreas, Xavier, Charles-Peter, Stumpf, Maria, Noegel, Angelika A., Clemen, Christoph S.
Coronin 3 involvement in F-actin-dependent processes at the cell cortex (2007)
Rosentreter, Andre, Hofmann, Andreas, Xavier, Charles-Peter, Stumpf, Maria, Noegel, Angelika A., Clemen, Christoph S.
Pathological consequences of VCP mutations on human striated muscle (2007)
Hübbers, Christian U., Clemen, Christoph S., Kesper, Kristina, Böddrich, Annett, Hofmann, Andreas, Kämäräinen, Outi, ...
Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13–p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone...
Schrickel, Jan W., Brixius, Klara, Herr, Claudia, Clemen, Christoph S., Sasse, Philipp, Reetz, Kathrin, ...
Objectives Annexin A7 is involved in cardiomyocyte membrane organization and Ca2+-dependent signalling processes. We investigated the impact of annexin A7 on cardiac electrophysiological properties...
Yusof, Adlina Mohd, Jaenicke, Elmar, Pedersen, Jan Skov, Noegel, Angelika A., Schleicher, Michael, Hofmann, Andreas
Cyclase-associated protein (CAP) is a highly conserved modular protein implicated in the regulation of actin filament dynamics and a variety of developmental and morphological processes. The protein...
Yusof, Adlina Mohd, Jaenicke, Elmar, Pedersen, Jan Skov, Noegel, Angelika A., Schleicher, Michael, Hofmann, Andreas
Cyclase-associated protein (CAP) is a highly conserved modular protein implicated in the regulation of actin filament dynamics and a variety of developmental and morphological processes. The protein...
Yusof, Adlina Mohd, Jaenicke, Elmar, Pedersen, Jan Skov, Noegel, Angelika A., Schleicher, Michael, Hofmann, Andreas
Cyclase-associated protein (CAP) is a highly conserved modular protein implicated in the regulation of actin filament dynamics and a variety of developmental and morphological processes. The protein...
Pathological consequences of VCP mutations on human striated muscle (2006)
Hübbers, Christian U., Clemen, Christoph S., Kesper, Kristina, Böddrich, Annett, Hofmann, Andreas, Kämäräinen, Outi, ...
Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone and...
Pathological consequences of VCP mutations on human striated muscle (2006)
Hübbers, Christian U., Clemen, Christoph S., Kesper, Kristina, Böddrich, Annett, Hofmann, Andreas, Kämäräinen, Outi, ...
Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone and...
Yusof, Adlina Mohd, Jaenicke, Elmar, Pedersen, Jan Skov, Noegel, Angelika A., Schleicher, Michael, Hofmann, Andreas
Cyclase-associated protein (CAP) is a highly conserved modular protein implicated in the regulation of actin filament dynamics and a variety of developmental and morphological processes. The protein...
Pathological consequences of VCP mutations on human striated muscle (2006)
Hübbers, Christian U., Clemen, Christoph S., Kesper, Kristina, Böddrich, Annett, Hofmann, Andreas, Kämäräinen, Outi, ...
Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone and...
Pathological consequences of VCP mutations on human striated muscle (2006)
Hübbers, Christian U., Clemen, Christoph S., Kesper, Kristina, Böddrich, Annett, Hofmann, Andreas, Kämäräinen, Outi, ...
Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone and...
The Dictyosteliumgenome encodes numerous RasGEFs with multiple biological roles (2005)
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
Abstract Background Dictyostelium discoideum is a eukaryote with a simple lifestyle and a relatively small genome whose sequence has been fully determined. It is widely used for studies on cell...
Nuclear localization of Annexin A7 during murine brain development (2005)
Rick, Michaela, Ramos Garrido, Soraya I, Herr, Claudia, Thal, Dietmar R, Noegel, Angelika A, Clemen, Christoph S
Abstract Background Annexin A7 is a member of the annexin protein family, which is characterized by its ability to interact with phospholipids in the presence of Ca 2+ -ions and which is thought to...
DictyMOLD-a Dictyostelium discoideum genome browser database (2005)
Felder, Marius, Szafranski, Karol, Lehmann, Rüdiger, Eichinger, Ludwig, Noegel, Angelika A., Platzer, Matthias, ...
Summary: With the Dictyostelium Genome Project nearing completion, we initiated the construction of a data repository for all Dictyostelium discoideum genomic data. Up to now this database, called...
Dictymold - a Dictyostelium discoideum genome browser database (2005)
Felder, Marius, Szafranski, Karol, Lehmann, Rüdiger, Eichinger, Ludwig, Noegel, Angelika A., Platzer, Matthias, ...
Summary: With the Dictyostelium Genome Project nearing completion, we initiated the construction of a data repository for all Dictyostelium discoideum genomic data. Up to now this database, called...
Herr, Claudia, Clemen, Christoph S, Lehnert, Gisela, Kutschkow, Rüdiger, Picker, Susanne M, Gathof, Birgit S, ...
Abstract Background Annexin A7 is a Ca 2+ - and phospholipid-binding protein expressed as a 47 and 51 kDa isoform, which is thought to be involved in membrane fusion processes. Recently the 47 kDa...
Crystallization of cyclase-associated protein from Dictyostelium discoideum (2002)
Hofmann, Andreas, Hess, Sonja, Noegel, Angelika A., Schleicher, Michael, Wlodawer, Alexander
Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which...
Crystallization of cyclase-associated protein from Dictyostelium discoideum (2002)
Hofmann, Andreas, Hess, Sonja, Noegel, Angelika A., Schleicher, Michael, Wlodawer, Alexander
Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which...
Crystallization of cyclase-associated protein from Dictyostelium discoideum (2002)
Hofmann, Andreas, Hess, Sonja, Noegel, Angelika A., Schleicher, Michael, Wlodawer, Alexander
Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which...
Herr, Claudia, Smyth, Neil, Ullrich, Susanne, Yun, Fan, Sasse, Phillip, Hescheler, Jürgen, ...
Annexin A7 has been proposed to function in the fusion of vesicles, acting as a Ca2+ channel and as Ca2+-activated GTPase, thus inducing Ca2+/GTP-dependent secretory events. To understand the...
The Dictyostelium discoideum family of Rho-related proteins (2001)
Rivero, Francisco, Dislich, Heidrun, Glöckner, Gernot, Noegel, Angelika A.
Taking advantage of the ongoing Dictyostelium genome sequencing project, we have assembled >73 kb of genomic DNA in 15 contigs harbouring 15 genes and one pseudogene of Rho-related proteins....
Rivero, Francisco, Albrecht, Richard, Dislich, Heidrun, Bracco, Enrico, Graciotti, Laura, Bozzaro, Salvatore, ...
Using a PCR approach we have isolated racF1, a novel member of the Rho family in Dictyostelium. The racF1 gene encodes a protein of 193 amino acids and is constitutively expressed throughout the...
The Dictyostelium discoideum family of Rho-related proteins
Rivero, Francisco, Dislich, Heidrun, Glöckner, Gernot, Noegel, Angelika A.
Taking advantage of the ongoing Dictyostelium genome sequencing project, we have assembled >73 kb of genomic DNA in 15 contigs harbouring 15 genes and one pseudogene of Rho-related proteins....
Herr, Claudia, Smyth, Neil, Ullrich, Susanne, Yun, Fan, Sasse, Phillip, Hescheler, Jürgen, ...
Annexin A7 has been proposed to function in the fusion of vesicles, acting as a Ca2+ channel and as Ca2+-activated GTPase, thus inducing Ca2+/GTP-dependent secretory events. To understand the...
Functions of LIM proteins in cell polarity and chemotactic motility
Khurana, Bharat, Khurana, Taruna, Khaire, Nandkumar, Noegel, Angelika A.
LimC and LimD are two novel LIM proteins of Dictyostelium, which are comprised of double and single LIM domains, respectively. Green fluorescent protein-fused LimC and LimD proteins preferentially...
Loss of the F-Actin Binding and Vesicle-Associated Protein Comitin Leads to a Phagocytosis Defect
Schreiner, Thomas, Mohrs, Martina R., Blau-Wasser, Rosemarie, Von Krempelhuber, Alfred, Steinert, Michael, Schleicher, Michael, ...
Comitin is an F-actin binding and membrane-associated protein from Dictyostelium discoideum, which is present on Golgi and vesicle membranes and changes its localization in response to agents...
NEW EMBO MEMBER’S REVIEW: Crawling into a new era—the Dictyostelium genome project
Eichinger, Ludwig, Noegel, Angelika A.
The social amoeba Dictyostelium discoideum is a well-established model organism for the study of basic aspects of differentiation, signal transduction, phagocytosis, cytokinesis and cell motility....
Gloss, Annika, Rivero, Francisco, Khaire, Nandkumar, Müller, Rolf, Loomis, William F., Schleicher, Michael, ...
Villidin is a novel multidomain protein (190 kDa) from Dictyostelium amoebae containing WD repeats at its N-terminus, three PH domains in the middle of the molecule, and five gelsolin-like segments...
Herr, Claudia, Clemen, Christoph S, Lehnert, Gisela, Kutschkow, Rüdiger, Picker, Susanne M, Gathof, Birgit S, ...
The Cyclase-associated Protein CAP as Regulator of Cell Polarity and cAMP Signaling in Dictyostelium
Noegel, Angelika A., Blau-Wasser, Rosemarie, Sultana, Hameeda, Müller, Rolf, Israel, Lars, Schleicher, Michael, ...
Cyclase-associated protein (CAP) is an evolutionarily conserved regulator of the G-actin/F-actin ratio and, in yeast, is involved in regulating the adenylyl cyclase activity. We show that cell...
Nuclear localization of Annexin A7 during murine brain development
Rick, Michaela, Ramos Garrido, Soraya I, Herr, Claudia, Thal, Dietmar R, Noegel, Angelika A, Clemen, Christoph S
Lamin A/C–dependent Localization of Nesprin-2, a Giant Scaffolder at the Nuclear Envelope
Libotte, Thorsten, Zaim, Hafida, Abraham, Sabu, Padmakumar, V. C., Schneider, Maria, Lu, Wenshu, ...
The vertebrate proteins Nesprin-1 and Nesprin-2 (also referred to as Enaptin and NUANCE) together with ANC-1 of Caenorhabditis elegans and MSP-300 of Drosophila melanogaster belong to a novel family...
The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
A survey of the Dictyostelium genome reveals at least 25 RasGEFs, all of which appear to be expressed at some point in development. Disruption of several of these novel RasGEFs reveals that many have...
Schwaiger, Ingo, Schleicher, Michael, Noegel, Angelika A, Rief, Matthias
The F-actin crosslinker filamin from Dictyostelium discoideum (ddFLN) has a rod domain consisting of six structurally similar immunoglobulin domains. When subjected to a stretching force, domain 4...
Chu, Haiyan, Thievessen, Ingo, Sixt, Michael, Lämmermann, Tim, Waisman, Ari, Braun, Attila, ...
Integrins regulate cell behavior through the assembly of multiprotein complexes at the site of cell adhesion. Parvins are components of such a multiprotein complex. They consist of three members...
Rivero, Francisco, Albrecht, Richard, Dislich, Heidrun, Bracco, Enrico, Graciotti, Laura, Bozzaro, Salvatore, ...
Using a PCR approach we have isolated racF1, a novel member of the Rho family in Dictyostelium. The racF1 gene encodes a protein of 193 amino acids and is constitutively expressed throughout the...
The Dictyostelium discoideum family of Rho-related proteins
Rivero, Francisco, Dislich, Heidrun, Glöckner, Gernot, Noegel, Angelika A.
Taking advantage of the ongoing Dictyostelium genome sequencing project, we have assembled >73 kb of genomic DNA in 15 contigs harbouring 15 genes and one pseudogene of Rho-related proteins....
Herr, Claudia, Smyth, Neil, Ullrich, Susanne, Yun, Fan, Sasse, Phillip, Hescheler, Jürgen, ...
Annexin A7 has been proposed to function in the fusion of vesicles, acting as a Ca2+ channel and as Ca2+-activated GTPase, thus inducing Ca2+/GTP-dependent secretory events. To understand the...
Functions of LIM proteins in cell polarity and chemotactic motility
Khurana, Bharat, Khurana, Taruna, Khaire, Nandkumar, Noegel, Angelika A.
LimC and LimD are two novel LIM proteins of Dictyostelium, which are comprised of double and single LIM domains, respectively. Green fluorescent protein-fused LimC and LimD proteins preferentially...
Loss of the F-Actin Binding and Vesicle-Associated Protein Comitin Leads to a Phagocytosis Defect
Schreiner, Thomas, Mohrs, Martina R., Blau-Wasser, Rosemarie, Von Krempelhuber, Alfred, Steinert, Michael, Schleicher, Michael, ...
Comitin is an F-actin binding and membrane-associated protein from Dictyostelium discoideum, which is present on Golgi and vesicle membranes and changes its localization in response to agents...
NEW EMBO MEMBER’S REVIEW: Crawling into a new era—the Dictyostelium genome project
Eichinger, Ludwig, Noegel, Angelika A.
The social amoeba Dictyostelium discoideum is a well-established model organism for the study of basic aspects of differentiation, signal transduction, phagocytosis, cytokinesis and cell motility....
Gloss, Annika, Rivero, Francisco, Khaire, Nandkumar, Müller, Rolf, Loomis, William F., Schleicher, Michael, ...
Villidin is a novel multidomain protein (190 kDa) from Dictyostelium amoebae containing WD repeats at its N-terminus, three PH domains in the middle of the molecule, and five gelsolin-like segments...
Herr, Claudia, Clemen, Christoph S, Lehnert, Gisela, Kutschkow, Rüdiger, Picker, Susanne M, Gathof, Birgit S, ...
The Cyclase-associated Protein CAP as Regulator of Cell Polarity and cAMP Signaling in Dictyostelium
Noegel, Angelika A., Blau-Wasser, Rosemarie, Sultana, Hameeda, Müller, Rolf, Israel, Lars, Schleicher, Michael, ...
Cyclase-associated protein (CAP) is an evolutionarily conserved regulator of the G-actin/F-actin ratio and, in yeast, is involved in regulating the adenylyl cyclase activity. We show that cell...
Nuclear localization of Annexin A7 during murine brain development
Rick, Michaela, Ramos Garrido, Soraya I, Herr, Claudia, Thal, Dietmar R, Noegel, Angelika A, Clemen, Christoph S
Lamin A/C–dependent Localization of Nesprin-2, a Giant Scaffolder at the Nuclear Envelope
Libotte, Thorsten, Zaim, Hafida, Abraham, Sabu, Padmakumar, V. C., Schneider, Maria, Lu, Wenshu, ...
The vertebrate proteins Nesprin-1 and Nesprin-2 (also referred to as Enaptin and NUANCE) together with ANC-1 of Caenorhabditis elegans and MSP-300 of Drosophila melanogaster belong to a novel family...
The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
A survey of the Dictyostelium genome reveals at least 25 RasGEFs, all of which appear to be expressed at some point in development. Disruption of several of these novel RasGEFs reveals that many have...
Schwaiger, Ingo, Schleicher, Michael, Noegel, Angelika A, Rief, Matthias
The F-actin crosslinker filamin from Dictyostelium discoideum (ddFLN) has a rod domain consisting of six structurally similar immunoglobulin domains. When subjected to a stretching force, domain 4...
Chu, Haiyan, Thievessen, Ingo, Sixt, Michael, Lämmermann, Tim, Waisman, Ari, Braun, Attila, ...
Integrins regulate cell behavior through the assembly of multiprotein complexes at the site of cell adhesion. Parvins are components of such a multiprotein complex. They consist of three members...
GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development
Prabhu, Yogikala, Müller, Rolf, Anjard, Christophe, Noegel, Angelika A
GxcDD, a putative RacGEF, is involved in Dictyostelium development
Mondal, Subhanjan, Neelamegan, Dhamodharan, Rivero, Francisco, Noegel, Angelika A
Rivero, Francisco, Kuspa, Adam, Brokamp, Regine, Matzner, Monika, Noegel, Angelika A.
In a search for novel members of the α-actinin superfamily, a Dictyostelium discoideum genomic library in yeast artificial chromosomes (YAC) was screened under low stringency conditions using the...
Karakesisoglou, Iakowos, Janssen, Klaus-Peter, Eichinger, Ludwig, Noegel, Angelika A., Schleicher, Michael
Profilin is an ubiquitous G-actin binding protein in eukaryotic cells. Lack of both profilin isoforms in Dictyostelium discoideum resulted in impaired cytokinesis and an arrest in development. A...
Joseph, Jayabalan M., Fey, Petra, Ramalingam, Nagendran, Liu, Xiao I., Rohlfs, Meino, Noegel, Angelika A., ...
Actin belongs to the most abundant proteins in eukaryotic cells which harbor usually many conventional actin isoforms as well as actin-related proteins (Arps). To get an overview over the sometimes...
Mondal, Subhanjan, Bakthavatsalam, Deenadayalan, Steimle, Paul, Gassen, Berthold, Rivero, Francisco, Noegel, Angelika A.
Ras guanine nucleotide exchange factor (GEF) Q, a nucleotide exchange factor from Dictyostelium discoideum, is a 143-kD protein containing RasGEF domains and a DEP domain. We show that RasGEF Q can...