Angelo Scorpio

Poly-gamma-Glutamate Capsule-Degrading Enzyme Treatment Enhances Phagocytosis and Killing of Encapsulated Bacillus Anthracis (2007)

Scorpio, Angelo, Chabot, Donald J., Day, William A., O'Brien, David K., Vietri, Nicholas J., Itoh, Yoshifumi, ...

The poly gamma-D-glutamic acid capsule confers antiphagocytic properties on Bacillus anthracis and is essential for virulence. In this study, we showed that two recombinant glutamylases: CapD, a...

Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid (2003)

Zhang, Ying, Wade, Mary Margaret, Scorpio, Angelo, Zhang, Hao, Sun, Zhonghe

Pyrazinamide is an important sterilizing drug that shortens tuberculosis (TB) therapy. However, the mechanism of action of pyrazinamide is poorly understood because of its unusual properties. Here we...

Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid (2003)

Zhang, Ying, Wade, Mary Margaret, Scorpio, Angelo, Zhang, Hao, Sun, Zhonghe

Pyrazinamide is an important sterilizing drug that shortens tuberculosis (TB) therapy. However, the mechanism of action of pyrazinamide is poorly understood because of its unusual properties. Here we...

Stress response proteins in Borrelia burgdorferi : subcellular localization and physiological function of the chaperone proteins HSP60 and HSP70; regulation of stress protein synthesis by exposure to Ixodes scapularis Saliva (Acari:Ixodidae) / (1995)

Scorpio, Angelo.

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Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide

Zhang, Ying, Scorpio, Angelo, Nikaido, Hiroshi, Sun, Zhonghe

Pyrazinamide (PZA) is an important antituberculosis drug. Unlike most antibacterial agents, PZA, despite its remarkable in vivo activity, has no activity against Mycobacterium tuberculosis in vitro...

Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide

Zhang, Ying, Scorpio, Angelo, Nikaido, Hiroshi, Sun, Zhonghe

Pyrazinamide (PZA) is an important antituberculosis drug. Unlike most antibacterial agents, PZA, despite its remarkable in vivo activity, has no activity against Mycobacterium tuberculosis in vitro...

Poly-γ-Glutamate Capsule-Degrading Enzyme Treatment Enhances Phagocytosis and Killing of Encapsulated Bacillus anthracis▿

Scorpio, Angelo, Chabot, Donald J., Day, William A., O'Brien, David K., Vietri, Nicholas J., Itoh, Yoshifumi, ...

The poly-γ-d-glutamic acid capsule confers antiphagocytic properties on Bacillus anthracis and is essential for virulence. In this study, we showed that CapD, a γ-polyglutamic acid depolymerase...

Treatment of Experimental Anthrax with Recombinant Capsule Depolymerase▿

Scorpio, Angelo, Tobery, Steven A., Ribot, Wilson J., Friedlander, Arthur M.

Bacillus anthracis produces an antiphagocytic gamma-linked poly-d-glutamic acid capsule that is required for virulence. Capsule depolymerase (CapD) is a membrane-associated poly-γ-glutamate-specific...