Metabolic stress signaling mediated by mixed-lineage kinases (2007)
Jaeschke, Anja, Davis, Roger J.
Saturated free fatty acid (FFA) is a major source of metabolic stress that activates the c-Jun NH(2)-terminal kinase (JNK). This FFA-stimulated JNK pathway is relevant to hallmarks of metabolic...
Jaeschke, Anja, Rincon, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna S., Greiner, Dale L., ...
The c-Jun NH(2)-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades (2005)
Brancho, Deborah Marie, Ventura, Juan-Jose, Jaeschke, Anja, Doran, Beth, Flavell, Richard A., Davis, Roger J.
Mixed-lineage protein kinase 3 (MLK3) is a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated in multiple signaling cascades, including the NF-kappaB...
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue (2004)
Jaeschke, Anja, Czech, Michael P., Davis, Roger J.
The c-Jun NH2-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits...
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue (2004)
Jaeschke, Anja, Czech, Michael P., Davis, Roger J.
The c-Jun NH2-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits...
Mechanism of p38 MAP kinase activation in vivo (2003)
Brancho, Deborah Marie, Tanaka, Nobuyuki, Jaeschke, Anja, Ventura, Juan-Jose, Kelkar, Nyaya, Tanaka, Yoshinori, ...
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism...
Mechanism of p38 MAP kinase activation in vivo (2003)
Brancho, Deborah, Tanaka, Nobuyuki, Jaeschke, Anja, Ventura, Juan-Jose, Kelkar, Nyaya, Tanaka, Yoshinori, ...
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism...
Mechanism of p38 MAP kinase activation in vivo (2003)
Brancho, Deborah, Tanaka, Nobuyuki, Jaeschke, Anja, Ventura, Juan-Jose, Kelkar, Nyaya, Tanaka, Yoshinori, ...
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism...
Mechanism of p38 MAP kinase activation in vivo
Brancho, Deborah, Tanaka, Nobuyuki, Jaeschke, Anja, Ventura, Juan-Jose, Kelkar, Nyaya, Tanaka, Yoshinori, ...
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism...
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
Jaeschke, Anja, Czech, Michael P., Davis, Roger J.
The c-Jun NH2-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits...
Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades
Brancho, Deborah, Ventura, Juan-Jose, Jaeschke, Anja, Doran, Beth, Flavell, Richard A., Davis, Roger J.
Mixed-lineage protein kinase 3 (MLK3) is a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated in multiple signaling cascades, including the NF-κB...
Jaeschke, Anja, Rincón, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna, Greiner, Dale L., ...
The c-Jun NH2-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Mechanism of p38 MAP kinase activation in vivo
Brancho, Deborah, Tanaka, Nobuyuki, Jaeschke, Anja, Ventura, Juan-Jose, Kelkar, Nyaya, Tanaka, Yoshinori, ...
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism...
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
Jaeschke, Anja, Czech, Michael P., Davis, Roger J.
The c-Jun NH2-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits...
Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades
Brancho, Deborah, Ventura, Juan-Jose, Jaeschke, Anja, Doran, Beth, Flavell, Richard A., Davis, Roger J.
Mixed-lineage protein kinase 3 (MLK3) is a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated in multiple signaling cascades, including the NF-κB...
Jaeschke, Anja, Rincón, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna, Greiner, Dale L., ...
The c-Jun NH2-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Jaeschke, Anja, Hartkamp, Joerg, Saitoh, Masao, Roworth, Wendy, Nobukuni, Takahiro, Hodges, Angela, ...
The evolution of mitogenic pathways has led to the parallel requirement for negative control mechanisms, which prevent aberrant growth and the development of cancer. Principally, such negative...