Johansson, Magnus, Lewis, Lionel D, Karlsson, Anna
The nucleoside analogs 9-beta-D-arabinofuranosylguanine (araG) and 1-beta-d-arabinofuranosylthymine (araT) are substrates of mitochondrial nucleoside kinases and have previously been shown to be...
Exploring Value Potential in a Function-Focused Industry (2009)
KARLSSON, ANNA, BLOMSTERLIND, JOHN
ABSTRACT Key words: Axiology, Value of Exchange, Blue Ocean Strategy, Docking Equipment, Key Value Factor, Value Co-Creation, The STACC Value Model Issue of Study: In a typical red ocean - an...
Van Daele, Ineke, Negri, Ana, Solaroli, Nicola, Karlsson, Anna, ...
Substituted 3'-thiourea derivatives of beta-thymidine (dThd) and 5'-thiourea derivatives of alpha-dThd have been evaluated for their inhibitory activity against recombinant human cytosolic dThd...
Josefin Fernebro, Ana Carneiro, Anders Rydholm, Henryk A. Domanski, Anna Karlsson, Åke Borg, ...
Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is...
IT Governance med fokus på IT-investeringar (2009)
Lindström, Lena-Maria, Karlsson, Anna
AbstractDate 2009-06-07Level Master thesis in Information Technology and Business Administration, 15 hp, EIK024Authors Anna Karlsson,...
Karlsson, Anna, Christenson, Karin, Matlak, Mustafa, Björstad, Åse, Brown, Kelly L, Telemo, Esbjörn, ...
Galectin-3, a β-galactoside binding, endogenous lectin, takes part in various inflammatory events and is produced in substantial amounts at inflammatory foci. We investigated whether extracellular...
IT Governance med fokus på IT-investeringar (2009)
Lindström, Lena-Maria, Karlsson, Anna
AbstractDate 2009-06-07Level Master thesis in Information Technology and Business Administration, 15 hp, EIK024Authors Anna Karlsson,...
Eriksson, Margaretha, Eriksson, Charlotte, Karlsson, Anna
Syftet med denna studie var att analysera skriftligt arbetsmaterial och offentliga informationsdokument som ligger till grund för förändringsarbete för ett ökat brukarinflytande gällande...
Karlsson, Anna, Mikaelsson, Marita
Syftet med uppsatsen är att undersöka vilken betydelse och påverkan samtalet med studie- och yrkesvägledaren har för utlandsfödda elever med icke svenska föräldrar som är sent anlända till...
Karlsson, Anna, Mikaelsson, Marita
Syftet med uppsatsen är att undersöka vilken betydelse och påverkan samtalet med studie- och yrkesvägledaren har för utlandsfödda elever med icke svenska föräldrar som är sent anlända till...
Prognostic Impact of Array-based Genomic Profiles in Esophageal Squamous Cell Cancer (2008)
Carneiro, Ana, Isinger, Anna, Karlsson, Anna, Johansson, Jan, Jönsson, Göran, Bendahl, Pär-Ola, ...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked...
Franco, Maribel, Johansson, Magnus, Karlsson, Anna
The nucleoside analog 2',3'-dideoxycytidine (ddC) has been used for treatment of human immunodeficiency virus (HIV) infections. ddC causes delayed toxicity when cells are exposed to the drug at low...
Brännborn, Pernilla, Jardfelt, Johanna, Karlsson, Anna
This paper deals with the food economy in the Mesolithic ? Neolithic settlement Sjöholmen from excavation in 1961 lead by Ingeborg Tillander. This material has been compared with the material from...
Årstidsdynamik för kvicksilver i ett sövattensediment : (2008)
The limit for mercury in fish, set by health authorities, is exceeded in about half of the lakes in Sweden. Methyl mercury (MeHg) is the most toxic form of mercury and accumulates in fish. Therefore...
Davidsson, Emelie, Karlsson, Anna
Denna uppsats tar upp problematiken kring arbetsgivarrollen inom mjölkproduktion. För att få en inblick i vardagen och vilka utmaningar arbetsgivarrollen medför har vi intervjuat tio stycken...
Hantering av IT-incidenter : En fallstudie på ICAs IT-avdelning Operations (2008)
Lindström, Lena-Maria, Karlsson, Anna, Wretlund, Magnus
Date: 2008-10-06Level: Bachelor thesis within Information Technology and business economics, 15p, EIK021Authors: Anna Karlsson, akn05009@student.mdh.seLena-Maria Lindström,...
Karlsson, Anna, Magnusson, Emma
Forskning visar att cirka 15 % av svenska elever har specifika matematiksvårigheter samt att många elever även har låg tilltro till sitt kunnande i matematik. Forskning åskådliggör även att...
Syftet med denna studie är att undersöka hur idrottslärare metodiskt arbetar för elever med AD/HD i idrottsundervisningen. Begreppen inkludering och exkludering beskrivs i arbetet. Bakgrunden...
Forsman, Huamei, Salomonsson, Emma, Önnheim, Karin, Karlsson, Jennie, Björstad, Åse, Leffler, Hakon, ...
Neutrophils interacting with a chemoattractant gradually become nonresponsive to further stimulation by the same agonist, a process known as desensitization. Receptor desensitization is a highly...
Josefin Fernebro, Ana Carneiro, Anders Rydholm, Henryk A. Domanski, Anna Karlsson, Åke Borg, ...
Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is...
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice (2008)
Zhou, Xiaoshan, Solaroli, Nicola, Bjerke, Mia, Stewart, James B., Rozell, Björn, Johansson, Magnus, ...
Deficient enzymatic activity of the mitochondrial deoxyribonucleoside kinases deoxyguanosine kinase (DGUOK) or thymidine kinase 2 (TK2) cause mitochondrial DNA (mtDNA)-depletion syndromes in humans....
Syftet med denna studie är att undersöka hur idrottslärare metodiskt arbetar för elever med AD/HD i idrottsundervisningen. Begreppen inkludering och exkludering beskrivs i arbetet. Bakgrunden...
Karlsson, Anna, Magnusson, Emma
Forskning visar att cirka 15 % av svenska elever har specifika matematiksvårigheter samt att många elever även har låg tilltro till sitt kunnande i matematik. Forskning åskådliggör även att...
Hantering av IT-incidenter : En fallstudie på ICAs IT-avdelning Operations (2008)
Lindström, Lena-Maria, Karlsson, Anna, Wretlund, Magnus
Date: 2008-10-06Level: Bachelor thesis within Information Technology and business economics, 15p, EIK021Authors: Anna Karlsson, akn05009@student.mdh.seLena-Maria Lindström,...
Zheng, Xinyu, Johansson, Magnus, Karlsson, Anna
The multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) is studied as a candidate suicide gene for applications in combined gene/chemotherapy of...
Cancer is one of the main causes of death in the world, particularly in developing countries and is considered as a major public health problem. Radiation therapy has been an important modality for...
Manfredini, Stefano, Angusti, Angela, Durini, Elisa, Solaroli, Nicola, Vertuani, Silvia, ...
Selective and effective TK2 inhibitors can be obtained by introduction of bulky lipophilic chains (acyl or alkyl entities) at the 2' position of araT and BVaraU, nucleoside analogues naturally...
Synen på de hemlösa och deras livssituation : - en kvalitativ studie (2007)
Karlsson, Anna, Svantesson, Kerstin
AbstractThe intention of our study is to examine how the view of homeless people and their life situation looks according to a selection of persons, which in their work get into contact with homeless...
Synen på de hemlösa och deras livssituation : - en kvalitativ studie (2007)
Karlsson, Anna, Svantesson, Kerstin
AbstractThe intention of our study is to examine how the view of homeless people and their life situation looks according to a selection of persons, which in their work get into contact with homeless...
Carlsson, Susanne, Oberg, Christopher T, Carlsson, Michael C, Sundin, Anders, Nilsson, Ulf J, Smith, David, ...
Abstract is not available
Effekter av olika tillväxthastigheter under kalvperioden : (2007)
Karlsson, Anna, Dieden, Kristina
Rekryteringsdjur i svenska mjölkkobesättningar har traditionsmässigt inte blivit uppmärksammade. Tiden från födsel till inkalvning ses ofta som en kostsam transportsträcka. Det är först när...
N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors (2006)
Familiar, Olga, Negri, Ana, Rodríguez-Barrios, Fatima, Gago, Federico, Karlsson, Anna, ...
Novel N1-substituted thymine derivatives related to 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine have been synthesized and evaluated against thymidine kinase-2 (TK-2) and related nucleoside kinases...
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design (2006)
El Omari, Kamel, Solaroli, Nicola, Karlsson, Anna, Balzarini, Jan, Stammers, David K
Abstract Background Development of countermeasures to bioterrorist threats such as those posed by the smallpox virus (variola), include vaccination and drug development. Selective activation of...
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design (2006)
Solaroli, Nicola, Karlsson, Anna, Stammers, David K
BACKGROUND: Development of countermeasures to bioterrorist threats such as those posed by the smallpox virus (variola), include vaccination and drug development. Selective activation of nucleoside...
Solaroli, Nicola, El Omari, Kamel, Stammers, David K, Karlsson, Anna
Studies of herpes simplex virus type 1 (HSV-1) thymidine (dThd) kinase (TK) crystal structures show that purine and pyrimidine bases occupy distinct positions in the active site but approximately the...
Karlsson, Anna, Svensson, Helena
This essay deals with the subject of the use of news medium amongst the students inKarlstads University. The presentation of the problem is about illustrating the or thosemedium that is the most used...
Karlsson, Anna, Svensson, Helena
This essay deals with the subject of the use of news medium amongst the students inKarlstads University. The presentation of the problem is about illustrating the or thosemedium that is the most used...
Cutaneous Human Papillomaviruses Persist on Healthy Skin. (2006)
Hazard, Kristina, Karlsson, Anna, Andersson, Kristin, Ekberg, Henrik, Dillner, Joakim, Forslund, Ola
Abstract is not available
Karlsson, Anna, De Groot, Tjibbe
Thymidine (Thd), 1-beta-D-arabinosylthymine (ara-T) and 3'-fluoro-3'-deoxythymidine (FLT) have been substituted at N-3 by a methyl or a 2-fluoroethyl group. FLT and ara-T are markedly inhibitory...
Föräldrar till vuxna narkotikamissbrukare och deras kontakter med socialtjänsten (2006)
The objective of this thesis was to study how parents of adult drug addicts experience their contact with the social welfare office, what elements affected the parents degree of satisfaction with the...
Eriksson, Anna, Karlsson, Anna, Jönsson, Helena
Bakgrund och problem: Den 1 januari 2006 trädde den nya aktiebolagslagen i kraft. En ändring som skett är att koncernspärren försvunnit, vilket i sin tur har lett till att uppdelning på bundet...
Företags syn på kundlojalitet – En undersökning av företag i Göteborgsregionen (2006)
Jivegård, Johan, Karlsson, Anna
Bakgrund och problem: Kundlojalitet är ett begrepp som fått allt större betydelse under de senaste årtiondena och påstås av många ha ett positivt samband med lönsamhet. På senare tid har...
Daniel Granfeldt, Olle Harbecke, Åse Björstad, Anna Karlsson, Claes Dahlgren
We have investigated calcium-induced secretion in human neutrophils, using a whole-cell patch-clamp technique. Mobilization of subcellular granules to the cell membrane was followed as the change in...
Franco, Maribel, Johansson, Magnus, Karlsson, Anna
The multisubstrate nucleoside kinase of Drosophila melanogaster (Dm-dNK) can be expressed in human solid tumor cells and its unique enzymatic properties makes this enzyme a suicide gene candidate. In...
Pellmé, Sara, Mörgelin, Matthias, Tapper, Hans, Mellqvist, Ulf-Henrik, Dahlgren, Claes, Karlsson, Anna
Abstract is not available
Fu, Huamei, Björkman, Lena, Janmey, Paul, Karlsson, Anna, Karlsson, Jennie, Movitz, Charlotta, ...
Abstract Background The formylpeptide receptor family members FPR and FPRL1, expressed in myeloid phagocytes, belong to the G-protein coupled seven transmembrane receptor family (GPCRs). They share a...
När fritidspedagogen kom in i skolan blev det enligt tidigare forskning i hög grad på lärarnas villkor. Fritidspedagogerna pekades ut som hjälplärare. Hur är det idag, tio år senare? I denna...
Förskollärarens yrkesroll (2004)
Bengtsson, Hanna, Karlsson, Anna
Förskolläraryrket är ett mångfacetterat praktiskt yrke och därför vill vi se hur verksamma förskollärare uppfattar sin yrkesroll samt vad de anser att de har för ansvar och arbetsuppgifter....
Karlsson, Anna, Camarasa, María-José, Pérez-Pérez, María-Jesús
Based on the structure of our previously identified mitochondrial thymidine kinase (TK-2) inhibitors, three series of thymine-derived carboxamides have been synthesized and tested against TK-2 and...
Van Rompay, An R, Bird, Louise E, Ren, Jingshan, ...
The phenylmethylthiazolylthiourea (PETT) derivative MSK-076 shows, besides high potency against human immunodeficiency virus type 1 (HIV-1), marked activity against HIV-2 (50% effective...
IASBs bildande av ett regelverk för SME - ur ett svenskt perspektiv (2004)
ERIKSSON, CATRIN, KARLSSON, ANNA, HJORTSBERG, INGRID
Syftet med vår uppsats är att bidra med kunskap om IASBs arbete för små och medelstora företag för att utvärdera om svenska småföretag tas i beaktande i IASBs pågående normbildningsprocess...
Bylund, Johan, Pellmé, Sara, Fu, Huamei, Mellqvist, Ulf-Henrik, Hellstrand, Kristoffer, Karlsson, Anna, ...
Abstract Background Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an...
När fritidspedagogen kom in i skolan blev det enligt tidigare forskning i hög grad på lärarnas villkor. Fritidspedagogerna pekades ut som hjälplärare. Hur är det idag, tio år senare? I denna...
Förskollärarens yrkesroll (2004)
Bengtsson, Hanna, Karlsson, Anna
Förskolläraryrket är ett mångfacetterat praktiskt yrke och därför vill vi se hur verksamma förskollärare uppfattar sin yrkesroll samt vad de anser att de har för ansvar och arbetsuppgifter....
Förskollärarens yrkesroll (2004)
Bengtsson, Hanna, Karlsson, Anna
Förskolläraryrket är ett mångfacetterat praktiskt yrke och därför vill vi se hur verksamma förskollärare uppfattar sin yrkesroll samt vad de anser att de har för ansvar och arbetsuppgifter....
När fritidspedagogen kom in i skolan blev det enligt tidigare forskning i hög grad på lärarnas villkor. Fritidspedagogerna pekades ut som hjälplärare. Hur är det idag, tio år senare? I denna...
Rodríguez-Barrios, Fátima, San-Félix, Ana, Karlsson, Anna, Gago, Federico, ...
Two series of analogues of the novel human mitochondrial thymidine kinase inhibitor 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine were synthesized by replacing the triphenylmethoxy moiety by a...
Rampazzo, Chiara, Scaini, Maria Chiara, Gallinaro, Lisa, Karlsson, Anna, Meier, Chris, ...
Nucleoside analogs act as prodrugs that must be converted to 5'-phosphates by intracellular kinases to become active in the treatment of viral and oncological diseases. Activation may be reversed by...
Hernández, Ana-Isabel, Roche, Philippe, Esnouf, Robert, Karlsson, Anna, Camarasa, Maria-José, ...
5'-O-Trityl derivatives of thymidine (dThd), (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), and their acyclic analogs 1-[(Z)-4-triphenylmethoxy-2-butenyl]thymine (KIN-12) and...
Gustavsson, Helen, Karlsson, Anna, Bäck, Sven A J, Olsson, Lars E, Haraldsson, Pia, Engström, Per, ...
Abstract is not available
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase (2002)
Karlsson, Anna, Camarasa, María-José, Pérez-Pérez, María-Jesús
A series of acyclic nucleoside analogues of 5'-O-tritylthymidine have been synthesized and evaluated as potential human mitochondrial thymidine kinase (TK-2) inhibitors. In this series, the sugar...
Tapper, Hans, Karlsson, Anna, Mörgelin, Matthias, Flodgaard, Hans, Herwald, Heiko
Human neutrophils have an important role in host defense against microbial infection. At different stages of an infectious process, neutrophils progressively up-regulate receptors and release various...
Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase (2002)
Schneider, Benoit, Norda, Ameli, Karlsson, Anna, Veron, Michel, Deville-Bonne, Dominique
Nucleoside diphosphate (NDP) kinase is transiently phosphorylated on a histidine of the active site during the catalytic cycle. In the presence of a nucleotide acceptor, the phosphohistidine bond is...
Reproduction in the Hermaphrodite Aeolidiella glauca - A Tale of Two Sexes (2001)
This thesis focuses on reproduction in a simultaneous hermaphrodite with internal fertilization; the nudibranch Aeolidiella glauca. Unlike most other nudibranchs, where copulation is the rule, A....
Reproduction in the Hermaphrodite Aeolidiella glauca - A Tale of Two Sexes (2001)
This thesis focuses on reproduction in a simultaneous hermaphrodite with internal fertilization; the nudibranch Aeolidiella glauca. Unlike most other nudibranchs, where copulation is the rule, A....
Human deoxycytidine kinase is located in the cell nucleus
Johansson, Magnus, Brismar, Sophia, Karlsson, Anna
Human deoxyribonucleoside kinases are required for the pharmacological activity of several clinically important anticancer and antiviral nucleoside analogs. Human deoxycytidine kinase and thymidine...
Balzarini, Jan, Pelemans, Heidi, Karlsson, Anna, De Clercq, Erik, Kleim, Jörg-Peter
Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant...
Proinflammatory Activity of a Cecropin-Like Antibacterial Peptide from Helicobacter pylori
Bylund, Johan, Christophe, Thierry, Boulay, Francois, Nyström, Thomas, Karlsson, Anna, Dahlgren, Claes
Helicobacter pylori, the bacterial pathogen associated with gastritis and peptic ulcers, is highly successful in establishing infection in the human gastric mucosa, a process typically associated...
Almkvist, Jenny, Fäldt, Jenny, Dahlgren, Claes, Leffler, Hakon, Karlsson, Anna
We have earlier shown that galectin-3, a lactose-binding mammalian lectin that is secreted from activated macrophages, basophils, and mast cells, induces activation of the NADPH oxidase in exudated...
Karlsson, Anna, Saravia-Otten, Patricia, Tegmark, Karin, Morfeldt, Eva, Arvidson, Staffan
Data have been presented indicating that Staphylococcus aureus cell surface protein can be degraded by extracellular proteases produced by the same bacterium. We have found that in sarA mutant cells,...
Degrève, Bart, Johansson, Magnus, De Clercq, Erik, Karlsson, Anna, Balzarini, Jan
The thymidine kinases (TKs) of herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) were expressed in human osteosarcoma cells as fusion proteins with the green fluorescent...
Balzarini, Jan, Camarasa, Maria-José, Pérez-Pérez, Maria-Jesus, San-Félix, Ana, Velázquez, Sonsoles, Perno, Carlo-Federico, ...
The RNA genome of the lentivirus human immunodeficiency virus type 1 (HIV-1) is significantly richer in adenine nucleotides than the statistically equal distribution of the four different nucleotides...
Wheat germ agglutinin (WGA), a lectin with specificity for N-acetylglucosamine and sialic acid, was investigated with respect to its ability to activate the NADPH-oxidase of in vivo-exudated...
Bylund, Johan, Karlsson, Anna, Boulay, Francois, Dahlgren, Claes
The cecropin-like bactericidal peptide Hp(2-20) from Helicobacter pylori induces activation of the NADPH oxidase in human neutrophils via formyl peptide receptor-like 1 (FPRL1) (J. Bylund, T....
Karlsson, Anna, Arvidson, Staffan
Staphylococcus aureus produces four major extracellular proteases: staphylococcal serine protease (V8 protease; SspA), cysteine protease (SspB), metalloprotease (aureolysin; Aur), and staphopain...
Auwerx, Joeri, Stevens, Miguel, Van Rompay, An R., Bird, Louise E., Ren, Jingshan, De Clercq, Erik, ...
The phenylmethylthiazolylthiourea (PETT) derivative MSK-076 shows, besides high potency against human immunodeficiency virus type 1 (HIV-1), marked activity against HIV-2 (50% effective...
Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils
Bylund, Johan, Pellmé, Sara, Fu, Huamei, Mellqvist, Ulf-Henrik, Hellstrand, Kristoffer, Karlsson, Anna, ...
Interleukin-8-Derived Peptide Has Antibacterial Activity
Björstad, Åse, Fu, Huamei, Karlsson, Anna, Dahlgren, Claes, Bylund, Johan
Chemokines are inflammatory mediators with effects on diverse processes associated with the immune response. Some of the proteins belonging to the CXC chemokine subfamily, one of four groups in the...
Itou, Takuya, Collins, L. Vincent, Thorén, Fredrik B., Dahlgren, Claes, Karlsson, Anna
To study different activation states in polymorphonuclear leukocytes (PMN) in mice, we compared the function of murine PMN obtained from the bone marrow (BMPMN) with those of PMN obtained by...
Granfeldt, Daniel, Harbecke, Olle, Björstad, Åse, Karlsson, Anna, Dahlgren, Claes
We have investigated calcium-induced secretion in human neutrophils, using a whole-cell patch-clamp technique. Mobilization of subcellular granules to the cell membrane was followed as the change in...
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
El Omari, Kamel, Solaroli, Nicola, Karlsson, Anna, Balzarini, Jan, Stammers, David K
Human deoxycytidine kinase is located in the cell nucleus
Johansson, Magnus, Brismar, Sophia, Karlsson, Anna
Human deoxyribonucleoside kinases are required for the pharmacological activity of several clinically important anticancer and antiviral nucleoside analogs. Human deoxycytidine kinase and thymidine...
Balzarini, Jan, Pelemans, Heidi, Karlsson, Anna, De Clercq, Erik, Kleim, Jörg-Peter
Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant...
Proinflammatory Activity of a Cecropin-Like Antibacterial Peptide from Helicobacter pylori
Bylund, Johan, Christophe, Thierry, Boulay, Francois, Nyström, Thomas, Karlsson, Anna, Dahlgren, Claes
Helicobacter pylori, the bacterial pathogen associated with gastritis and peptic ulcers, is highly successful in establishing infection in the human gastric mucosa, a process typically associated...
Almkvist, Jenny, Fäldt, Jenny, Dahlgren, Claes, Leffler, Hakon, Karlsson, Anna
We have earlier shown that galectin-3, a lactose-binding mammalian lectin that is secreted from activated macrophages, basophils, and mast cells, induces activation of the NADPH oxidase in exudated...
Karlsson, Anna, Saravia-Otten, Patricia, Tegmark, Karin, Morfeldt, Eva, Arvidson, Staffan
Data have been presented indicating that Staphylococcus aureus cell surface protein can be degraded by extracellular proteases produced by the same bacterium. We have found that in sarA mutant cells,...
Degrève, Bart, Johansson, Magnus, De Clercq, Erik, Karlsson, Anna, Balzarini, Jan
The thymidine kinases (TKs) of herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) were expressed in human osteosarcoma cells as fusion proteins with the green fluorescent...
Balzarini, Jan, Camarasa, Maria-José, Pérez-Pérez, Maria-Jesus, San-Félix, Ana, Velázquez, Sonsoles, Perno, Carlo-Federico, ...
The RNA genome of the lentivirus human immunodeficiency virus type 1 (HIV-1) is significantly richer in adenine nucleotides than the statistically equal distribution of the four different nucleotides...
Wheat germ agglutinin (WGA), a lectin with specificity for N-acetylglucosamine and sialic acid, was investigated with respect to its ability to activate the NADPH-oxidase of in vivo-exudated...
Bylund, Johan, Karlsson, Anna, Boulay, Francois, Dahlgren, Claes
The cecropin-like bactericidal peptide Hp(2-20) from Helicobacter pylori induces activation of the NADPH oxidase in human neutrophils via formyl peptide receptor-like 1 (FPRL1) (J. Bylund, T....
Karlsson, Anna, Arvidson, Staffan
Staphylococcus aureus produces four major extracellular proteases: staphylococcal serine protease (V8 protease; SspA), cysteine protease (SspB), metalloprotease (aureolysin; Aur), and staphopain...
Auwerx, Joeri, Stevens, Miguel, Van Rompay, An R., Bird, Louise E., Ren, Jingshan, De Clercq, Erik, ...
The phenylmethylthiazolylthiourea (PETT) derivative MSK-076 shows, besides high potency against human immunodeficiency virus type 1 (HIV-1), marked activity against HIV-2 (50% effective...
Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils
Bylund, Johan, Pellmé, Sara, Fu, Huamei, Mellqvist, Ulf-Henrik, Hellstrand, Kristoffer, Karlsson, Anna, ...
Interleukin-8-Derived Peptide Has Antibacterial Activity
Björstad, Åse, Fu, Huamei, Karlsson, Anna, Dahlgren, Claes, Bylund, Johan
Chemokines are inflammatory mediators with effects on diverse processes associated with the immune response. Some of the proteins belonging to the CXC chemokine subfamily, one of four groups in the...
Itou, Takuya, Collins, L. Vincent, Thorén, Fredrik B., Dahlgren, Claes, Karlsson, Anna
To study different activation states in polymorphonuclear leukocytes (PMN) in mice, we compared the function of murine PMN obtained from the bone marrow (BMPMN) with those of PMN obtained by...
Granfeldt, Daniel, Harbecke, Olle, Björstad, Åse, Karlsson, Anna, Dahlgren, Claes
We have investigated calcium-induced secretion in human neutrophils, using a whole-cell patch-clamp technique. Mobilization of subcellular granules to the cell membrane was followed as the change in...
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
El Omari, Kamel, Solaroli, Nicola, Karlsson, Anna, Balzarini, Jan, Stammers, David K
Fu, Huamei, Bylund, Johan, Karlsson, Anna, Pellmé, Sara, Dahlgren, Claes
Neutrophil chemotaxis has been shown to be regulated by two different signalling pathways that allow strong chemoattractants, such as bacterial-derived formylated peptides, to dominate over...
Karlsson, Anna, Nygren, Erik, Karlsson, Jennie, Nordström, Inger, Dahlgren, Claes, Eriksson, Kristina
We show that human monocyte-derived dendritic cells (DC) differ considerably from freshly isolated blood-derived myeloid and plasmacytoid DC in their abilities to produce reactive oxygen species in...
Prognostic Impact of Array-based Genomic Profiles in Esophageal Squamous Cell Cancer
Carneiro, Ana, Isinger, Anna, Karlsson, Anna, Johansson, Jan, Jönsson, Göran, Bendahl, Pär-Ola, ...
Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase
Schneider, Benoit, Norda, Ameli, Karlsson, Anna, Veron, Michel, Deville-Bonne, Dominique
Nucleoside diphosphate (NDP) kinase is transiently phosphorylated on a histidine of the active site during the catalytic cycle. In the presence of a nucleotide acceptor, the phosphohistidine bond is...
Fernebro, Josefin, Carneiro, Ana, Rydholm, Anders, Domanski, Henryk A., Karlsson, Anna, Borg, Åke, ...
Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is...
Egesten, Arne, Olin, Anders I., Linge, Helena M., Yadav, Manisha, Mörgelin, Matthias, Karlsson, Anna, ...
Leaching of Flame Retardants from products deposited in Landfills
Hörsing, Maritha, Karlsson, Anna, Jonsson, Susanne, Svensson, Bo H
Materials in many products in daily use are amended with chemicals to give them desired properties, e.g. flame retardants (FRs) used to reduce the risks of products catching fire. However,...