Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs (2008)
Rong, Liwei, Livingstone, Mark, Sukarieh, Rami, Petroulakis, Emmanuel, Gingras, Anne-Claude, Crosby, Katherine, ...
Eukaryotic initiation factor (eIF) 4E, the mRNA 5′-cap-binding protein, mediates the association of eIF4F with the mRNA 5′-cap structure to stimulate cap-dependent translation initiation in the...
ZUBEREK, JOANNA, WYSLOUCH-CIESZYNSKA, ALEKSANDRA, NIEDZWIECKA, ANNA, DADLEZ, MICHAL, STEPINSKI, JANUSZ, AUGUSTYNIAK, WOJCIECH, ...
Phosphorylation of the eukaryotic initiation factor eIF4E in response to mitogenic stimuli and cytokines is implicated in the regulation of the initiation step of translation. It still remains...
Tang, Shao Jun, Reis, Gerald, Kang, Hyejin, Gingras, Anne-Claude, Sonenberg, Nahum, Schuman, Erin M.
Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTIP) that endures for more than an hour requires both...
Regulation of the translational inhibitor 4E-BP1 by phosphorylation / (2001)
Written for the Dept. of Biochemistry.
Regulation of the translational inhibitor 4E-BP1 by phosphorylation (2001)
In most instances, translation is regulated at the initiation phase, when a ribosome is recruited to the 5' end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict cap-dependent translation...
Hierarchical phosphorylation of the translation inhibitor 4E-BP1 (2001)
Gingras, Anne-Claude, Raught, Brian, Gygi, Steven P., Niedzwiecka, Anna, Miron, Mathieu, Burley, Stephen K., ...
Regulation of the translational inhibitor 4E-BP1 by phosphorylation (2001)
In most instances, translation is regulated at the initiation phase, when a ribosome is recruited to the 5' end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict cap-dependent translation...
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism (1999)
Gingras, Anne-Claude, Gygi, Steven P., Raught, Brian, Polakiewicz, Roberto D., Abraham, Robert T., Hoekstra, Merl F., ...
The target of rapamycin (TOR) proteins
Raught, Brian, Gingras, Anne-Claude, Sonenberg, Nahum
Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and...
Khaleghpour, Kianoush, Pyronnet, Stéphane, Gingras, Anne-Claude, Sonenberg, Nahum
Eukaryotic translation initiation factor 4E (eIF4E) is the mRNA 5′ cap binding protein, which plays an important role in the control of translation. The activity of eIF4E is regulated by a family...
Rapamycin and Wortmannin Enhance Replication of a Defective Encephalomyocarditis Virus
Svitkin, Yuri V., Hahn, Harry, Gingras, Anne-Claude, Palmenberg, Ann C., Sonenberg, Nahum
Inhibitors of the phosphatidylinositol 3-kinase (PI3 kinase)–FKBP-rapamycin-associated protein (FRAP) pathway, such as rapamycin and wortmannin, induce dephosphorylation and activation of the...
Tang, Shao Jun, Reis, Gerald, Kang, Hyejin, Gingras, Anne-Claude, Sonenberg, Nahum, Schuman, Erin M.
Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTP) that endures for more than an hour requires both...
Li, Shunan, Sonenberg, Nahum, Gingras, Anne-Claude, Peterson, Mark, Avdulov, Svetlana, Polunovsky, Vitaly A., ...
Translational control has been recently added to well-recognized genomic, transcriptional, and posttranslational mechanisms regulating apoptosis. We previously found that overexpressed eukaryotic...
Raught, Brian, Gingras, Anne-Claude, Gygi, Steven P., Imataka, Hiroaki, Morino, Shigenobu, Gradi, Alessandra, ...
The eukaryotic translation initiation factor 4G (eIF4G) proteins play a critical role in the recruitment of the translational machinery to mRNA. The eIF4Gs are phosphoproteins. However, the location...
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
Gingras, Anne-Claude, Raught, Brian, Gygi, Steven P., Niedzwiecka, Anna, Miron, Mathieu, Burley, Stephen K., ...
In most instances, translation is regulated at the initiation phase, when a ribosome is recruited to the 5′ end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict translation initiation by...
Gingras, Anne-Claude, Kennedy, Scott G., O’Leary, Maura A., Sonenberg, Nahum, Hay, Nissim
Growth factors and hormones activate protein translation by phosphorylation and inactivation of the translational repressors, the eIF4E-binding proteins (4E-BPs), through a wortmannin- and...
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
Gingras, Anne-Claude, Gygi, Steven P., Raught, Brian, Polakiewicz, Roberto D., Abraham, Robert T., Hoekstra, Merl F., ...
The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5′ end of mRNA. The eIF4F subunit eIF4E interacts directly with the mRNA 5′ cap...
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
Raught, Brian, Peiretti, Franck, Gingras, Anne-Claude, Livingstone, Mark, Shahbazian, David, Mayeur, Greg L, ...
The eucaryotic translation initiation factor 4B (eIF4B) stimulates the helicase activity of the DEAD box protein eIF4A to unwind inhibitory secondary structure in the 5′ untranslated region of...
Svitkin, Yuri V., Herdy, Barbara, Costa-Mattioli, Mauro, Gingras, Anne-Claude, Raught, Brian, Sonenberg, Nahum
Translation of m7G-capped cellular mRNAs is initiated by recruitment of ribosomes to the 5′ end of mRNAs via eukaryotic translation initiation factor 4F (eIF4F), a heterotrimeric complex comprised...
ZUBEREK, JOANNA, WYSLOUCH-CIESZYNSKA, ALEKSANDRA, NIEDZWIECKA, ANNA, DADLEZ, MICHAL, STEPINSKI, JANUSZ, AUGUSTYNIAK, WOJCIECH, ...
Phosphorylation of the eukaryotic initiation factor eIF4E in response to mitogenic stimuli and cytokines is implicated in the regulation of the initiation step of translation. It still remains...
Advances in protein complex analysis using mass spectrometry
Gingras, Anne-Claude, Aebersold, Ruedi, Raught, Brian
Proteins often function as components of larger complexes to perform a specific function, and formation of these complexes may be regulated. For example, intracellular signalling events often require...
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs
Rong, Liwei, Livingstone, Mark, Sukarieh, Rami, Petroulakis, Emmanuel, Gingras, Anne-Claude, Crosby, Katherine, ...
Eukaryotic initiation factor (eIF) 4E, the mRNA 5′-cap-binding protein, mediates the association of eIF4F with the mRNA 5′-cap structure to stimulate cap-dependent translation initiation in the...
PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint
Nakada, Shinichiro, Chen, Ginny I, Gingras, Anne-Claude, Durocher, Daniel
Phosphorylation of histone H2AX on Ser 139 (γH2AX) is one of the earliest events in the response to DNA double-strand breaks; however, the subsequent removal of γH2AX from chromatin is less...
PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint
Nakada, Shinichiro, Chen, Ginny I, Gingras, Anne-Claude, Durocher, Daniel
PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4*S⃞
Chen, Ginny I., Tisayakorn, Sally, Jorgensen, Claus, D'Ambrosio, Lisa M., Goudreault, Marilyn, Gingras, Anne-Claude
Protein serine/threonine phosphatase 4 (PP4c) is an essential polypeptide involved in critical cellular processes such as microtubule growth and organization, DNA damage checkpoint recovery,...