Sleep-disordered Breathing and Frailty in the Cardiovascular Health Study Cohort (2009)
Endeshaw, Yohannes W., Unruh, Mark L., Kutner, Michael, Newman, Anne B., Bliwise, Donald L.
Sleep-disordered breathing (SDB) is associated with pathophysiology that may influence the development and progression of frailty. Using data collected in 1995–1996, the authors explored the...
Njajou, Omer T., Hsueh, Wen-Chi, Blackburn, Elizabeth H., Newman, Anne B., Wu, Shih-Hsuan, Li, Rongling, ...
Although telomere length (TL) is known to play a critical role in cellular senescence, the relationship of TL to aging and longevity in humans is not well understood. In a large biracial...
Hsu, Fang-Chi, Kritchevsky, Stephen B., Liu, Yongmei, Kanaya, Alka, Newman, Anne B., Perry, Sara E., ...
Background In older adults, studies demonstrate an inverse relationship between physical function and individual inflammatory biomarkers. Given that the inflammatory response is a complex system, a...
Williamson, Jeff D., Espeland, Mark, Kritchevsky, Stephen B., Newman, Anne B., King, Abby C., Pahor, Marco, ...
Background Cognitive impairment is an important contributor to disability. Limited clinical trial evidence exists regarding the impact of physical exercise on cognitive function (CF). We report...
Manini, Todd M., Everhart, James E., Patel, Kushang V., Schoeller, Dale A., Cummings, Steve, Mackey, Dawn C., ...
In this study, the authors aimed to determine whether higher activity energy expenditure, assessed by using doubly labeled water, was associated with a reduced decline in mobility limitation among...
Hanlon, Joseph T., Boudreau, Robert M., Roumani, Yazan F., Newman, Anne B., Ruby, Christine M., Wright, Rollin M., ...
Background Few studies have examined the risk of multiple or high doses of combined central nervous system (CNS) medication use for recurrent falls in the elderly. The study objective was to evaluate...
Peterson, Matthew J., Giuliani, Carol, Morey, Miriam C., Pieper, Carl F., Evenson, Kelly R., Mercer, Vicki, ...
Background It is unclear if physical activity (PA) can prevent or reverse frailty. We examined different doses and types of PA and their association with the onset and severity of frailty. Methods...
Nicklas, Barbara J., Newman, Anne B., Harris, Tamara B., Goodpaster, Bret H., Satterfield, Suzanne, ...
Background The metabolic syndrome includes dyslipidemia, abdominal obesity, insulin resistance, and hypertension and is associated with an increased risk of diabetes and cerebrovascular disease...
Schaap, Laura A., Pluijm, Saskia M. F., Deeg, Dorly J. H., Harris, Tamara B., Kritchevsky, Stephen B., Newman, Anne B., ...
Background There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers...
Cystatin C and aging success (2008)
Sarnak, Mark J., Katz, Ronit, Fried, Linda F., Siscovick, David, Kestenbaum, Brian, Seliger, Stephen, ...
Background: To our knowledge, the effect of kidney function on successful aging has not been examined. Methods: We evaluated the relationship between cystatin C and aging success during a 6-year...
Mukamal, Kenneth J., Kennedy, Margaret, Cushman, Mary, Kuller, Lewis H., Newman, Anne B., Polak, Joseph, ...
Few studies of the relation of alcohol intake to lower-extremity arterial disease (LEAD) have included clinical events and objective measurements repeated longitudinally. As part of the...
Inflammatory Markers and Longitudinal Lung Function Decline in the Elderly (2008)
Jiang, Rui, Burke, Gregory L., Enright, Paul L., Newman, Anne B., Margolis, Helene G., Cushman, Mary, ...
Longitudinal studies examining associations of the inflammatory markers fibrinogen and C-reactive protein (CRP) with lung function decline are sparse. The authors examined whether elevated fibrinogen...
Diehr, Paula, Derleth, Ann, Cai, Liming, Newman, Anne B
Abstract Background Choosing cost-effective strategies for improving the health of the public is difficult because the relative effects of different types of interventions are not well understood....
Metabolic syndrome and the risk of cardiovascular disease in older adults (2006)
Butler, Javed, Rodondi, Nicolas, Zhu, Yuwei, Figaro, Kathleen, Fazio, Sergio, Vaughan, Douglas E, ...
OBJECTIVES The Purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults. BACKGROUND The importance of MetSyn as a risk...
Metabolic syndrome and the risk of cardiovascular disease in older adults (2006)
Rodondi, Nicolas, Zhu, Yuwei, Figaro, Kathleen, Fazio, Sergio, Vaughan, Douglas E, ...
OBJECTIVES: The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults. BACKGROUND: The importance of MetSyn as a...
Different Public Health Interventions have Varying Effects (2006)
Diehr, Paula, Newman, Anne B., Cai, Liming, Derleth, Ann
Objective: To compare performance of one-time health interventions to those that change the probability of transitioning from one health state to another. Study Design and Setting: We used...
Different Public Health Interventions have Varying Effects (2006)
Diehr, Paula, Newman, Anne B., Cai, Liming, Derleth, Ann
Objective: To compare performance of one-time health interventions to those that change the probability of transitioning from one health state to another. Study Design and Setting: We used...
Different Public Health Interventions have Varying Effects (2006)
Diehr, Paula, Newman, Anne B., Cai, Liming, Derleth, Ann
Objective: To compare performance of one-time health interventions to those that change the probability of transitioning from one health state to another. Study Design and Setting: We used...
Different Public Health Interventions have Varying Effects (2006)
Diehr, Paula, Newman, Anne B., Cai, Liming, Derleth, Ann
Objective: To compare performance of one-time health interventions to those that change the probability of transitioning from one health state to another. Study Design and Setting: We used...
Odden, Michelle C., Chertow, Glenn M., Fried, Linda F., Newman, Anne B., Connelly, Stephanie, Angleman, Sara, ...
Most studies of the relation between kidney function and physical function have been conducted in persons with advanced kidney disease and have used creatinine-based measures of kidney function....
Kritchevsky, Stephen B, Nicklas, Barbara J, Koh-Banerjee, Pauline, ...
BACKGROUND: Oxidative damage plays an important role in leading to major health-related events. The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized...
Brach, Jennifer S, Berlin, Jaime E, VanSwearingen, Jessie M, Newman, Anne B, Studenski, Stephanie A
Abstract Background Decreased gait speed and increased stride time, stride length, double support time, and stance time variability have consistently been associated with falling whereas step width...
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women (2005)
Krishnaswami, Shanthi, Harris, Tamara B, Katsiaras, Andreas, Kritchevsky, Steven B, Simonsick, Eleanor M, ...
BACKGROUND: The metabolic syndrome is a disorder that includes dyslipidemia, insulin resistance, and hypertension and is associated with an increased risk of diabetes and cardiovascular disease. We...
Nicklas, Barbara J., Cesari, Matteo, Kritchevsky, Stephen B., Newman, Anne B., Kanaya, Alka M., ...
Assessment of body fat distribution, particularly visceral adipose tissue, may be important for accurate risk evaluation for cardiovascular disease in the elderly. This 1997–1998 US study examined...
Harris, Tamara B, Tracy, Russell P, Newman, Anne B, Rubin, Susan M, ...
OBJECTIVE: Although circulating oxidized LDL (oxLDL) is elevated in persons with coronary heart disease (CHD), whether oxLDL is elevated in persons with high CHD risk before any events is unknown....
Weight-modification trials in older adults: what should the outcome measure be? (2002)
Diehr, Paula, Newman, Anne B, Jackson, Sharon A, Kuller, Lewis, Powe, Neil
Abstract Background Overweight older adults are often counseled to lose weight, even though there is little evidence of excess mortality in that age group. Overweight and underweight may be more...
Newman, Anne B., Nieto, F. Javier, Guidry, Ursula, Lind, Bonnie K., Redline, Susan, Shahar, Eyal, ...
Associations between sleep-disordered breathing and cardiovascular disease (CVD) may be mediated by higher cardiovascular risk factor levels in those with sleep-disordered breathing. The authors...
Weight-modification trials in older adults: what should the outcome measure be?
Diehr, Paula, Newman, Anne B, Jackson, Sharon A, Kuller, Lewis, Powe, Neil
Stroke Risk in an Elderly Population with Atrial Fibrillation
Feinberg, William M, Kronmal, Richard A, Newman, Anne B, Kraut, Michael A, Bovill, Edwin G, Cooper, Lawton, ...
Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke, but the absolute rate of stroke varies widely depending on coexistent vascular disease. We assessed the stroke...
Weight-modification trials in older adults: what should the outcome measure be?
Diehr, Paula, Newman, Anne B, Jackson, Sharon A, Kuller, Lewis, Powe, Neil
Stroke Risk in an Elderly Population with Atrial Fibrillation
Feinberg, William M, Kronmal, Richard A, Newman, Anne B, Kraut, Michael A, Bovill, Edwin G, Cooper, Lawton, ...
Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke, but the absolute rate of stroke varies widely depending on coexistent vascular disease. We assessed the stroke...
Limited Literacy and Mortality in the Elderly: The Health, Aging, and Body Composition Study
Sudore, Rebecca L, Yaffe, Kristine, Satterfield, Suzanne, Harris, Tamara B, Mehta, Kala M, Simonsick, Eleanor M, ...
Goldman, Suzanne E., Stone, Katie L., Ancoli-Israel, Sonia, Blackwell, Terri, Ewing, Susan K., Boudreau, Robert, ...
A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)
Melzer, David, Perry, John R. B., Hernandez, Dena, Corsi, Anna-Maria, Stevens, Kara, Rafferty, Ian, ...
There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the...
Patel, Kushang V., Harris, Tamara B., Faulhaber, Marion, Angleman, Sara B., Connelly, Stephanie, Bauer, Douglas C., ...
Anemia is more common among older blacks than older whites. However, it is unclear whether anemia predicts adverse events similarly in both races. Data on 1018 black and 1583 white adults aged 71 to...
Association between Nighttime Sleep and Napping in Older Adults
Goldman, Suzanne E., Hall, Martica, Boudreau, Robert, Matthews, Karen A., Cauley, Jane A., Ancoli-Israel, Sonia, ...
4G/5G Plasminogen Activator Inhibitor-1 Polymorphisms and Haplotypes Are Associated with Pneumonia
Yende, Sachin, Angus, Derek C., Ding, Jingzhong, Newman, Anne B., Kellum, John A., Li, Rongling, ...
Rationale: Plasminogen activator inhibitor (PAI)-1 inhibits urokinase and tissue plasminogen activator, required for host response to infection. Whether variation within the PAI-1 gene is associated...
Further epidemiologic research on anemia in older adults is needed
Patel, Kushang V., Harris, Tamara B., Newman, Anne B., Guralnik, Jack M.
Mittalhenkle, Anuja, Stehman-Breen, Catherine O., Shlipak, Michael G., Fried, Linda F., Katz, Ronit, Young, Bessie A., ...
Background and objectives: Although the elderly are at increased risk for acute renal failure, few prospective studies have identified risk factors for acute renal failure in the elderly.
Sleep-disordered Breathing and Cardiovascular Disease: An Outcome-based Definition of Hypopneas
Punjabi, Naresh M., Newman, Anne B., Young, Terry B., Resnick, Helaine E., Sanders, Mark H.
Rationale: Epidemiologic studies on the consequences of sleep-disordered breathing invariably use the apnea–hypopnea index as the primary measure of disease severity. Although hypopneas constitute...
Diabetes Mellitus and Gait Dysfunction: Possible Explanatory Factors
Brach, Jennifer S, Talkowski, Jaime B, Strotmeyer, Elsa S, Newman, Anne B
Background and Objective: Gait characteristics differ in individuals with diabetes compared with those without diabetes. Limited information regarding potential explanatory factors for this...
Talkowski, Jaime B, Brach, Jennifer S, Studenski, Stephanie, Newman, Anne B
Background and Purpose: Disagreement currently exists regarding the contributions of various factors to physical activity in older adults. The purpose of this cross-sectional study was to investigate...
Preinfection Systemic Inflammatory Markers and Risk of Hospitalization Due to Pneumonia
Yende, Sachin, Tuomanen, Elaine I., Wunderink, Richard, Kanaya, Alka, Newman, Anne B., Harris, Tamara, ...
Rationale: Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear.
Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study
Punjabi, Naresh M., Caffo, Brian S., Goodwin, James L., Gottlieb, Daniel J., Newman, Anne B., O'Connor, George T., ...
In a cohort of 6,441 volunteers followed over an average of 8.2 years, Naresh Punjabi and colleagues find sleep-disordered breathing to be independently associated with mortality and identify...
Strotmeyer, Elsa S., De Rekeneire, Nathalie, Schwartz, Ann V., Faulkner, Kimberly A., Resnick, Helaine E., Goodpaster, Bret H., ...
OBJECTIVE—Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance.
Inflammatory Markers and Longitudinal Lung Function Decline in the Elderly
Jiang, Rui, Burke, Gregory L., Enright, Paul L., Newman, Anne B., Margolis, Helene G., Cushman, Mary, ...
Longitudinal studies examining associations of the inflammatory markers fibrinogen and C-reactive protein (CRP) with lung function decline are sparse. The authors examined whether elevated fibrinogen...
Goodpaster, Bret H., Chomentowski, Peter, Ward, Bryan K., Rossi, Andrea, Glynn, Nancy W., Delmonico, Matthew J., ...
Considerable evidence suggests that the loss of strength and muscle mass appear to be inevitable consequences of aging. Moreover, aging is associated with an increase in body fat. This study examined...