The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration. (2009)
Brazier, Hélène, Pawlak, Géraldine, Vives, Virginie, Blangy, Anne
An excess of osteoclastic bone resorption relative to osteoblastic bone formation results in progressive bone loss, characteristic of osteoporosis. Understanding the mechanisms of osteoclast...
The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration. (2009)
Brazier, Hélène, Pawlak, Géraldine, Vives, Virginie, Blangy, Anne
An excess of osteoclastic bone resorption relative to osteoblastic bone formation results in progressive bone loss, characteristic of osteoporosis. Understanding the mechanisms of osteoclast...
The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration. (2009)
Brazier, Hélène, Pawlak, Géraldine, Vives, Virginie, Blangy, Anne
An excess of osteoclastic bone resorption relative to osteoblastic bone formation results in progressive bone loss, characteristic of osteoporosis. Understanding the mechanisms of osteoclast...
Rho GTPases in osteoclasts: Orchestrators of podosome arrangement. (2008)
Ory, Stéphane, Brazier, Hélène, Pawlak, Géraldine, Blangy, Anne
Cells from the myeloid lineage, namely macrophages, dendritic cells and osteoclasts, develop podosomes instead of stress fibers and focal adhesions to adhere and migrate. Podosomes share many...
Rho GTPases in osteoclasts: Orchestrators of podosome arrangement. (2008)
Ory, Stéphane, Brazier, Hélène, Pawlak, Géraldine, Blangy, Anne
Cells from the myeloid lineage, namely macrophages, dendritic cells and osteoclasts, develop podosomes instead of stress fibers and focal adhesions to adhere and migrate. Podosomes share many...
Rho GTPases in osteoclasts: Orchestrators of podosome arrangement. (2008)
Ory, Stéphane, Brazier, Hélène, Pawlak, Géraldine, Blangy, Anne
Cells from the myeloid lineage, namely macrophages, dendritic cells and osteoclasts, develop podosomes instead of stress fibers and focal adhesions to adhere and migrate. Podosomes share many...
Ory, Stéphane, Brazier, Hélène, Blangy, Anne
Background information. Rho GTPases are important regulators of cytoskeleton dynamics and cell adhesion. RhoU/Wrch-1 is a Rho GTPase which shares sequence similarities with Rac1 and Cdc42 (cell...
Ory, Stéphane, Brazier, Hélène, Blangy, Anne
Background information. Rho GTPases are important regulators of cytoskeleton dynamics and cell adhesion. RhoU/Wrch-1 is a Rho GTPase which shares sequence similarities with Rac1 and Cdc42 (cell...
Brazier, Helene, Stephens, Sebastien Robert, Ory, Stephane, Fort, Philippe, Morrison, Nigel Alexander, Blangy, Anne
Yes
Brazier, Helene, Stephens, Sebastien Robert, Ory, Stephane, Fort, Philippe, Morrison, Nigel Alexander, Blangy, Anne, ...
Yes
Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay. (2006)
Blangy, Anne, Bouquier, Nathalie, Gauthier-Rouvière, Cécile, Schmidt, Susanne, Debant, Anne, Leonetti, Jean-Paul, ...
BACKGROUND INFORMATION: Rho GTPases are involved in many biological processes and participate in cancer development. Their activation is catalysed by exchange factors [RhoGEFs (Rho GTPase guanine...
Brazier, Hélène, Stephens, Sébastien, Ory, Stéphane, Fort, Philippe, Morrison, Nigel, Blangy, Anne
RhoGTPases regulate actin cytoskeleton dynamics, a key element in osteoclast biology. We identified three novel genes induced during RANKL-stimulated osteoclastogenesis among RhoGTPases and their...
Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay. (2006)
Blangy, Anne, Bouquier, Nathalie, Gauthier-Rouvière, Cécile, Schmidt, Susanne, Debant, Anne, Leonetti, Jean-Paul, ...
BACKGROUND INFORMATION: Rho GTPases are involved in many biological processes and participate in cancer development. Their activation is catalysed by exchange factors [RhoGEFs (Rho GTPase guanine...
Brazier, Hélène, Stephens, Sébastien, Ory, Stéphane, Fort, Philippe, Morrison, Nigel, Blangy, Anne
RhoGTPases regulate actin cytoskeleton dynamics, a key element in osteoclast biology. We identified three novel genes induced during RANKL-stimulated osteoclastogenesis among RhoGTPases and their...
Brazier, Helene, Stephens, Sebastien Robert, Ory, Stephane, Fort, Philippe, Morrison, Nigel Alexander, Blangy, Anne
Brazier, Helene, Stephens, Sebastien Robert, Ory, Stephane, Fort, Philippe, Morrison, Nigel Alexander, Blangy, Anne
Blangy, Anne, Léopold, Pierre, Vidal, Frédérique, Rassouizadegan, Minoo, Cuzin, Francois
We have reported previously (1) two unexpected consequences of the microinjection into fertilized mouse eggs of a recombinant plasmid designated p12B1c,a rrying a 343 bp insert of non-repetitive...
Mary, Sophie, Charrasse, Sophie, Meriane, Mayya, Comunale, Franck, Travo, Pierre, Blangy, Anne, ...
Cadherin-mediated cell-cell adhesion is a dynamic process that is regulated during embryonic development, cell migration, and differentiation. Different cadherins are expressed in specific tissues...
The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway
De Toledo, Marion, Senic-Matuglia, Francesca, Salamero, Jean, Uze, Gilles, Comunale, Franck, Fort, Philippe, ...
Rho GTPases are key regulators of actin dynamics. We report that the Rho GTPase TCL, which is closely related to Cdc42 and TC10, localizes to the plasma membrane and the early/sorting endosomes in...
Coelho, Luiz F. Leomil, De Freitas Almeida, Gabriel Magno, Mennechet, Franck J. D., Blangy, Anne, Uzé, Gilles
In humans, type I interferon (IFN) is a family of 17 cytokines, among which the α subtypes and the β subtype are differentially expressed. It has been suggested that IFN-β activates a specific...
RhoA GTPase Regulates M-Cadherin Activity and Myoblast FusionD⃞V⃞
Charrasse, Sophie, Comunale, Franck, Grumbach, Yaël, Poulat, Francis, Blangy, Anne, Gauthier-Rouvière, Cécile
The Rho family of GTP-binding proteins plays critical roles during myogenesis induction. To elucidate their role later during myogenesis, we have analyzed RhoA function during myoblast fusion into...
D'Angelo, Romina, Aresta, Sandra, Blangy, Anne, Del Maestro, Laurence, Louvard, Daniel, Arpin, Monique
The mechanisms underlying functional interactions between ERM (ezrin, radixin, moesin) proteins and Rho GTPases are not well understood. Here we characterized the interaction between ezrin and a...
Charrasse, Sophie, Meriane, Mayya, Comunale, Franck, Blangy, Anne, Gauthier-Rouvière, Cécile
N-cadherin, a member of the Ca2+-dependent cell–cell adhesion molecule family, plays an essential role in skeletal muscle cell differentiation. We show that inhibition of N-cadherin–dependent...
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo
Laurin, Mélanie, Fradet, Nadine, Blangy, Anne, Hall, Alan, Vuori, Kristiina, Côté, Jean-François
Dock1 (also known as Dock180) is a prototypical member of a new family of atypical Rho GTPase activators. Genetic studies in Drosophila and Caenorhabditis elegans have demonstrated that Dock1...