Anne Dell

The GlycanBuilder: a fast, intuitive and flexible software tool for building and displaying glycan structures (2007)

Ceroni, Alessio, Dell, Anne, Haslam, Stuart M

Abstract Background Carbohydrates play a critical role in human diseases and their potential utility as biomarkers for pathological conditions is a major driver for characterization of the glycome....

Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant (2007)

Tatituri, Raju Venkata Veera, Alderwick, Luke J, Mishra, Arun K., Nigou, Jerome, Gilleron, Martine, Krumbach, Karin, ...

Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the...

Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant (2007)

Tatituri, Raju Venkata Veera, Alderwick, Luke J, Mishra, Arun K., Nigou, Jerome, Gilleron, Martine, Krumbach, Karin, ...

Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the...

Identification of a capsular polysaccharide from moraxella bovis (2005)

Wilson, Jenny, Hitchen, Paul G, Frank, Martin, Peak, Ian, Collins, Patrick, Morris, Howard R., ...

The bacterium Moraxella bovis is the causative agent of an economically important disease of cattle: Infectious Bovine Keratoconjunctivitis (IBK), otherwise known as pinkeye. Little is known...

Identification of a capsular polysaccharide from moraxella bovis (2005)

Wilson, Jenny, Hitchen, Paul G, Frank, Martin, Peak, Ian, Collins, Patrick, Morris, Howard R., ...

The bacterium Moraxella bovis is the causative agent of an economically important disease of cattle: Infectious Bovine Keratoconjunctivitis (IBK), otherwise known as pinkeye. Little is known...

Identification of a capsular polysaccharide from moraxella bovis (2005)

Wilson, Jenny, Hitchen, Paul G, Frank, Martin, Peak, Ian, Collins, Patrick, Morris, Howard R., ...

The bacterium Moraxella bovis is the causative agent of an economically important disease of cattle: Infectious Bovine Keratoconjunctivitis (IBK), otherwise known as pinkeye. Little is known...

Differences in Glycosylation and Sperm-Egg Binding Inhibition of Pregnancy-Related Glycodelin1 (2003)

Hannu Koistinen, Richard L. Easton, Sara Chalabi, Mervi Halttunen, Anne Dell, ...

Glycodelin is a glycoprotein produced in many glands, particularly those of reproductive tissues. It appears as different glycoforms in amniotic fluid (glycodelin-A) and seminal plasma...

The contribution of tandem repeat number to the O-glycosylation of mucins (2003)

Silverman, Howard Scott, Sutton-Smith, Mark, McDermott, Kimberley, Heal, Paul, Leir, Shih-Hsing, Morris, Howard R., ...

The serine- and threonine-rich tandem repeat (TR) units that make up the characteristic feature of mucin glycoproteins are often polymorphic with substantial genetic variation in TR number. The...

In vivo glycosylation of mucin tandem repeats (2001)

Silverman, Howard S., Parry, Simon, Sutton-Smith, Mark, Burdick, Michael D., McDermott, Kimberly, Reid, Colm J., ...

The biochemical and biophysical properties of mucins are largely determined by extensive O-glycosylation of serine- and threonine-rich tandem repeat (TR) domains. In a number of human diseases...

Genetic remodeling of protein glycosylation in vivo induces autoimmune disease

Chui, Daniel, Sellakumar, Gayathri, Green, Ryan S., Sutton-Smith, Mark, McQuistan, Tammie, Marek, Kurt W., ...

Autoimmune diseases are among the most prevalent of afflictions, yet the genetic factors responsible are largely undefined. Protein glycosylation in the Golgi apparatus produces structural variation...

Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans

Dell, Anne, Chalabi, Sara, Easton, Richard L., Haslam, Stuart M., Sutton-Smith, Mark, Patankar, Manish S., ...

Murine sperm initiate fertilization by binding to the outer covering of the egg known as the murine zona pellucida (mZP). This binding is thought to require the interaction of O-glycans linked to a...

Field desorption mass spectrometry of oligosaccharides

Linscheid, Michael, D'Angona, Jay, Burlingame, Alma L., Dell, Anne, Ballou, Clinton E.

Field desorption mass spectrometry has been used to analyze carbohydrate polymers with 5 to 14 hexose units without prior derivatization. In all examples, the molecular weight of the oligosaccharide...

Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili

Hegge, Finn Terje, Hitchen, Paul G., Aas, Finn Erik, Kristiansen, Heidi, Løvold, Cecilia, Egge-Jacobsen, Wolfgang, ...

Several major bacterial pathogens and related commensal species colonizing the human mucosa express phosphocholine (PC) at their cell surfaces. PC appears to impact host–microbe biology by serving...

Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli

Feldman, Mario F., Wacker, Michael, Hernandez, Marcela, Hitchen, Paul G., Marolda, Cristina L., Kowarik, Michael, ...

Campylobacter jejuni has a general N-linked protein glycosylation system that can be functionally transferred to Escherichia coli. In this study, we engineered E. coli cells in a way that two...

Host-Pathogen Interactions 1: XXII. A Galacturonic Acid Oligosaccharide from Plant Cell Walls Elicits Phytoalexins

Nothnagel, Eugene A., McNeil, Michael, Albersheim, Peter, Dell, Anne

Elicitors of phytoalexin accumulation in soybean (Glycine max L. Merr., cv Wayne) cotyledons were released from soybean cell walls and from citrus pectin by partial acid hydrolysis. These two...

Host-Pathogen Interactions 1: XXIX. Oligogalacturonides Released from Sodium Polypectate by Endopolygalacturonic Acid Lyase Are Elicitors of Phytoalexins in Soybean

Davis, Keith R., Darvill, Alan G., Albersheim, Peter, Dell, Anne

Recent studies have demonstrated that an apparently homogeneous preparation of an α-1,4-d-endopolygalacturonic acid lyase (EC 4.2.2.2) isolated from the phytopathogenic bacterium Erwinia carotovora...

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Kremer, Laurent, Gurcha, Sudagar S, Bifani, Pablo, Hitchen, Paul G, Baulard, Alain, Morris, Howard R, ...

Phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM) and lipoarabinomannan (LAM) are an important class of bacterial factors termed modulins that are found in tuberculosis and leprosy....

Essential and mutually compensatory roles of α-mannosidase II and α-mannosidase IIx in N-glycan processing in vivo in mice

Akama, Tomoya O., Nakagawa, Hiroaki, Wong, Nyet Kui, Sutton-Smith, Mark, Dell, Anne, Morris, Howard R., ...

Many proteins synthesized through the secretory pathway receive posttranslational modifications, including N-glycosylation. α-Mannosidase II (MII) is a key enzyme converting precursor...

Genetic remodeling of protein glycosylation in vivo induces autoimmune disease

Chui, Daniel, Sellakumar, Gayathri, Green, Ryan S., Sutton-Smith, Mark, McQuistan, Tammie, Marek, Kurt W., ...

Autoimmune diseases are among the most prevalent of afflictions, yet the genetic factors responsible are largely undefined. Protein glycosylation in the Golgi apparatus produces structural variation...

Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans

Dell, Anne, Chalabi, Sara, Easton, Richard L., Haslam, Stuart M., Sutton-Smith, Mark, Patankar, Manish S., ...

Murine sperm initiate fertilization by binding to the outer covering of the egg known as the murine zona pellucida (mZP). This binding is thought to require the interaction of O-glycans linked to a...

Field desorption mass spectrometry of oligosaccharides

Linscheid, Michael, D'Angona, Jay, Burlingame, Alma L., Dell, Anne, Ballou, Clinton E.

Field desorption mass spectrometry has been used to analyze carbohydrate polymers with 5 to 14 hexose units without prior derivatization. In all examples, the molecular weight of the oligosaccharide...

Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili

Hegge, Finn Terje, Hitchen, Paul G., Aas, Finn Erik, Kristiansen, Heidi, Løvold, Cecilia, Egge-Jacobsen, Wolfgang, ...

Several major bacterial pathogens and related commensal species colonizing the human mucosa express phosphocholine (PC) at their cell surfaces. PC appears to impact host–microbe biology by serving...

Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli

Feldman, Mario F., Wacker, Michael, Hernandez, Marcela, Hitchen, Paul G., Marolda, Cristina L., Kowarik, Michael, ...

Campylobacter jejuni has a general N-linked protein glycosylation system that can be functionally transferred to Escherichia coli. In this study, we engineered E. coli cells in a way that two...

Host-Pathogen Interactions 1: XXII. A Galacturonic Acid Oligosaccharide from Plant Cell Walls Elicits Phytoalexins

Nothnagel, Eugene A., McNeil, Michael, Albersheim, Peter, Dell, Anne

Elicitors of phytoalexin accumulation in soybean (Glycine max L. Merr., cv Wayne) cotyledons were released from soybean cell walls and from citrus pectin by partial acid hydrolysis. These two...

Host-Pathogen Interactions 1: XXIX. Oligogalacturonides Released from Sodium Polypectate by Endopolygalacturonic Acid Lyase Are Elicitors of Phytoalexins in Soybean

Davis, Keith R., Darvill, Alan G., Albersheim, Peter, Dell, Anne

Recent studies have demonstrated that an apparently homogeneous preparation of an α-1,4-d-endopolygalacturonic acid lyase (EC 4.2.2.2) isolated from the phytopathogenic bacterium Erwinia carotovora...

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Kremer, Laurent, Gurcha, Sudagar S, Bifani, Pablo, Hitchen, Paul G, Baulard, Alain, Morris, Howard R, ...

Phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM) and lipoarabinomannan (LAM) are an important class of bacterial factors termed modulins that are found in tuberculosis and leprosy....

Essential and mutually compensatory roles of α-mannosidase II and α-mannosidase IIx in N-glycan processing in vivo in mice

Akama, Tomoya O., Nakagawa, Hiroaki, Wong, Nyet Kui, Sutton-Smith, Mark, Dell, Anne, Morris, Howard R., ...

Many proteins synthesized through the secretory pathway receive posttranslational modifications, including N-glycosylation. α-Mannosidase II (MII) is a key enzyme converting precursor...

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB′ mutant

Mishra, Arun K., Klein, Christina, Gurcha, Sudagar S., Alderwick, Luke J., Babu, Ponnusamy, Hitchen, Paul G., ...

The genus Corynebacterium is part of the phylogenetic group nocardioform actinomycetes, which also includes the genus Mycobacterium. Members of this phylogenetic group have a characteristic cell...

Identification of AglE, a Second Glycosyltransferase Involved in N Glycosylation of the Haloferax volcanii S-Layer Glycoprotein▿

Abu-Qarn, Mehtap, Giordano, Assunta, Battaglia, Francesca, Trauner, Andrej, Hitchen, Paul G., Morris, Howard R., ...

Archaea, like Eukarya and Bacteria, are able to N glycosylate select protein targets. However, in contrast to relatively advanced understanding of the eukaryal N glycosylation process and the...

A Filovirus-Unique Region of Ebola Virus Nucleoprotein Confers Aberrant Migration and Mediates Its Incorporation into Virions▿

Shi, Wei, Huang, Yue, Sutton-Smith, Mark, Tissot, Berangere, Panico, Maria, Morris, Howard R., ...

The Ebola virus nucleoprotein (NP) is an essential component of the nucleocapsid, required for filovirus particle formation and replication. Together with virion protein 35 (VP35) and VP24, this gene...

Comparative Efficacy of Neutralizing Antibodies Elicited by Recombinant Hemagglutinin Proteins from Avian H5N1 Influenza Virus▿

Wei, Chih-Jen, Xu, Ling, Kong, Wing-Pui, Shi, Wei, Canis, Kevin, Stevens, James, ...

Although the human transmission of avian H5N1 virus remains low, the prevalence of this highly pathogenic infection in avian species underscores the need for a preventive vaccine that can be made...