Anne E. Kwitek

Sequence Variation and Expression of the Gimap Gene Family in the BB Rat (2009)

Elizabeth A. Rutledge, Jessica M. Fuller, Brian Van Yserloo, Daniel H. Moralejo, Ruth A. Ettinger, Prashant Gaur, ...

Positional cloning of lymphopenia (lyp) in the BB rat revealed a frameshift mutation in Gimap5, a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome...

Sequence Variation and Expression of the Gimap Gene Family in the BB Rat (2009)

Elizabeth A. Rutledge, Jessica M. Fuller, Brian Van Yserloo, Daniel H. Moralejo, Ruth A. Ettinger, Prashant Gaur, ...

Positional cloning of lymphopenia (lyp) in the BB rat revealed a frameshift mutation in Gimap5, a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome...

FINAL ACCEPTED VERSION C-00234-2006.R1 (2008)

Nancy E Schlick, Kimberly Orlebeke, Anne E Kwitek, Howard J Jacob, Jozef Lazar

Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains

Contact Information: (2008)

Simon N. Twigger, Dean Pasko, Jeff Nie, Mary Shimoyama, Susan Bromberg, Dan Campbell, ...

2 PG-00040-2005.R1 The broad goal of physiological genomics research is to link genes to their functions using appropriate experimental and computational techniques. Modern genomics experiments...

influence susceptibility (2007)

Andrea Baessler, Marcus Fischer, Bjoern Mayer, Martina Koehler, Silke Wiedmann, Klaus Stark, ...

interaction between haplotypes of the ghrelin ligand and receptor genes

Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease (2007)

Baessler, Andrea, Fischer, Marcus, Mayer, Bjoern, Koehler, Martina, Wiedmann, Silke, Stark, Klaus, ...

Data from both experimental models and humans provide evidence that ghrelin and its receptor, the growth hormone secretagogue receptor (ghrelin receptor, GHSR), possess a variety of cardiovascular...

The Rat Genome Database, update 2007--Easing the path from disease to data and back again (2007)

Twigger, Simon N., Shimoyama, Mary, Bromberg, Susan, Kwitek, Anne E., Jacob, Howard J.

The Rat Genome Database (RGD, http://rgd.mcw.edu) is one of the core resources for rat genomics and recent developments have focused on providing support for disease-based research using the rat...

The Rat Genome Database, update 2007--Easing the path from disease to data and back again (2006)

Twigger, Simon N., Shimoyama, Mary, Bromberg, Susan, Kwitek, Anne E., Jacob, Howard J.

The Rat Genome Database (RGD, http://rgd.mcw.edu) is one of the core resources for rat genomics and recent developments have focused on providing support for disease-based research using the rat...

The Rat Genome Database, update 2007--Easing the path from disease to data and back again (2006)

Twigger, Simon N., Shimoyama, Mary, Bromberg, Susan, Kwitek, Anne E., Jacob, Howard J.

The Rat Genome Database (RGD, http://rgd.mcw.edu) is one of the core resources for rat genomics and recent developments have focused on providing support for disease-based research using the rat...

Impact of genomics on research in the rat (2005)

Lazar, Jozef, Moreno, Carol, Jacob, Howard J., Kwitek, Anne E.

The need to translate genes to function has positioned the rat as an invaluable animal model for genomic research. The significant increase in genomic resources in recent years has had an immediate...

Integrative Genomics: In Silico Coupling of Rat Physiology and Complex Traits With Mouse and Human Data (2004)

Twigger, Simon N., Nie, Jeff, Ruotti, Victor, Yu, Jiaming, Chen, Dan, Li, Dawei, ...

Integration of the large variety of genome maps from several organisms provides the mechanism by which physiological knowledge obtained in model systems such as the rat can be projected onto the...

High-Density Rat Radiation Hybrid Maps Containing Over 24,000 SSLPs, Genes, and ESTs Provide a Direct Link to the Rat Genome Sequence (2004)

Kwitek, Anne E., Gullings-Handley, Jo, Yu, Jiaming, Carlos, Danilo C., Orlebeke, Kimberly, Nie, Jeff, ...

The laboratory rat is a major model organism for systems biology. To complement the cornucopia of physiological and pharmacological data generated in the rat, a large genomic toolset has been...

Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays (2003)

Wang, Hong-Ying, Malek, Renae L, Kwitek, Anne E, Greene, Andrew S, Luu, Truong V, Behbahani, Babak, ...

Abstract Background Long oligonucleotide microarrays are potentially more cost- and management-efficient than cDNA microarrays, but there is little information on the relative performance of these...

Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays

Wang, Hong-Ying, Malek, Renae L, Kwitek, Anne E, Greene, Andrew S, Luu, Truong V, Behbahani, Babak, ...

Long oligonucleotide microarrays are potentially more cost- and management efficient than cDNA microarrays. Unmodified sense and antisense 70-mer oligonucleotides were synthesized and compared with...

Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene

MacMurray, Armand J., Moralejo, Daniel H., Kwitek, Anne E., Rutledge, Elizabeth A., Van Yserloo, Brian, Gohlke, Paul, ...

The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune diabetes and is used to study non-MHC loci contributing to Type 1 diabetes. Type 1 diabetes in the diabetes-prone BB...

Automated Construction of High-Density Comparative Maps Between Rat, Human, and Mouse

Kwitek, Anne E., Tonellato, Peter J., Chen, Dan, Gullings-Handley, Jo, Cheng, Yongjian Samuel, Twigger, Simon, ...

Animal models have been used primarily as surrogates for humans, having similar disease-based phenotypes. Genomic organization also tends to be conserved between species, leading to the generation of...

Integrative Genomics: In Silico Coupling of Rat Physiology and Complex Traits With Mouse and Human Data

Twigger, Simon N., Nie, Jeff, Ruotti, Victor, Yu, Jiaming, Chen, Dan, Li, Dawei, ...

Integration of the large variety of genome maps from several organisms provides the mechanism by which physiological knowledge obtained in model systems such as the rat can be projected onto the...

High-Density Rat Radiation Hybrid Maps Containing Over 24,000 SSLPs, Genes, and ESTs Provide a Direct Link to the Rat Genome Sequence

Kwitek, Anne E., Gullings-Handley, Jo, Yu, Jiaming, Carlos, Danilo C., Orlebeke, Kimberly, Nie, Jeff, ...

The laboratory rat is a major model organism for systems biology. To complement the cornucopia of physiological and pharmacological data generated in the rat, a large genomic toolset has been...

In silico Analysis of 2085 Clones from a Normalized Rat Vestibular Periphery 3′ cDNA Library

Roche, Joseph P., Wackym, P. Ashley, Cioffi, Joseph A., Kwitek, Anne E., Erbe, Christy B., Popper, Paul

The inserts from 2400 cDNA clones isolated from a normalized Rattus norvegicus vestibular periphery cDNA library were sequenced and characterized. The Wackym-Soares vestibular 3′ cDNA library was...

Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays

Wang, Hong-Ying, Malek, Renae L, Kwitek, Anne E, Greene, Andrew S, Luu, Truong V, Behbahani, Babak, ...

Long oligonucleotide microarrays are potentially more cost- and management efficient than cDNA microarrays. Unmodified sense and antisense 70-mer oligonucleotides were synthesized and compared with...

Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene

MacMurray, Armand J., Moralejo, Daniel H., Kwitek, Anne E., Rutledge, Elizabeth A., Van Yserloo, Brian, Gohlke, Paul, ...

The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune diabetes and is used to study non-MHC loci contributing to Type 1 diabetes. Type 1 diabetes in the diabetes-prone BB...

Automated Construction of High-Density Comparative Maps Between Rat, Human, and Mouse

Kwitek, Anne E., Tonellato, Peter J., Chen, Dan, Gullings-Handley, Jo, Cheng, Yongjian Samuel, Twigger, Simon, ...

Animal models have been used primarily as surrogates for humans, having similar disease-based phenotypes. Genomic organization also tends to be conserved between species, leading to the generation of...

Integrative Genomics: In Silico Coupling of Rat Physiology and Complex Traits With Mouse and Human Data

Twigger, Simon N., Nie, Jeff, Ruotti, Victor, Yu, Jiaming, Chen, Dan, Li, Dawei, ...

Integration of the large variety of genome maps from several organisms provides the mechanism by which physiological knowledge obtained in model systems such as the rat can be projected onto the...

High-Density Rat Radiation Hybrid Maps Containing Over 24,000 SSLPs, Genes, and ESTs Provide a Direct Link to the Rat Genome Sequence

Kwitek, Anne E., Gullings-Handley, Jo, Yu, Jiaming, Carlos, Danilo C., Orlebeke, Kimberly, Nie, Jeff, ...

The laboratory rat is a major model organism for systems biology. To complement the cornucopia of physiological and pharmacological data generated in the rat, a large genomic toolset has been...

The Rat Genome Database, update 2007—Easing the path from disease to data and back again

Twigger, Simon N., Shimoyama, Mary, Bromberg, Susan, Kwitek, Anne E., Jacob, Howard J.

The Rat Genome Database (RGD, ) is one of the core resources for rat genomics and recent developments have focused on providing support for disease-based research using the rat model. Recognizing the...

Sequence Variation and Expression of the Gimap Gene Family in the BB Rat

Rutledge, Elizabeth A., Fuller, Jessica M., Van Yserloo, Brian, Moralejo, Daniel H., Ettinger, Ruth A., Gaur, Prashant, ...

Positional cloning of lymphopenia (lyp) in the BB rat revealed a frameshift mutation in Gimap5, a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome...

Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease

Mattson, David L., Dwinell, Melinda R., Greene, Andrew S., Kwitek, Anne E., Roman, Richard J., Jacob, Howard J., ...

This study examined the genetic basis of hypertension and renal disease in Dahl SS/Mcwi (Dahl Salt-Sensitive) rats using a complete chromosome substitution panel of consomic rats in which each of the...