Kelly, Claire M., Precious, Sophie V., Penketh, Richard, Amso, Nazar, Dunnett, Stephen B., Rosser, Anne E.
Reconstruction of CNS circuitry is a major aim of neural transplantation, and is currently being assessed clinically using foetal striatal tissue in Huntington's disease. Recent work suggests that...
Joannides, Alexis J., Webber, Daniel J., Raineteau, Olivier, Kelly, Claire, Irvine, Karen-Amanda, Watts, Colin, ...
Human embryonic stem cells (hESCs) are a potential source of defined tissue for cell-based therapies in regenerative neurology. In order for this potential to be realized, there is a need for the...
Pavese, Nicola, Andrews, Thomasin C., Brooks, David J., Ho, Aileen K., Rosser, Anne E., Barker, Roger A., ...
We have studied the progression of striatal and extrastriatal post‐synaptic dopaminergic changes in a group of 12 patients with Huntington’s disease using serial 11C‐raclopride PET, a...
Armstrong, Richard J. E., Hurelbrink, Carrie B., Tyers, Pam, Ratcliffe, Emma L., Richards, Andrew, Dunnett, Stephen Bruce, ...
Neural precursors with the properties of neural stem cells can be isolated from the developing brain, can be expanded in culture, and have been suggested as a potential source of cells for neuronal...
Armstrong, Richard J. E., Hurelbrink, Carrie B., Tyers, Pam, Ratcliffe, Emma L., Richards, Andrew, Dunnett, Stephen Bruce, ...
Neural precursors with the properties of neural stem cells can be isolated from the developing brain, can be expanded in culture, and have been suggested as a potential source of cells for neuronal...
Huntington's disease progression: PET and clinical observations (1999)
Andrews, Thomasin C., Weeks, Robert A., Turjanski, Nora, Gunn, Roger N., Watkins, Laura H. A., Sahakian, Barbara, ...
Using serial [11C]SCH 23390- and [11C]raclopride-PET, we have measured the rate of loss of striatal dopamine D1 and D2 receptor binding over a mean of 40 months in nine...
Executive and mnemonic functions in early Huntington's disease (1996)
Lawrence, Andrew D., Sahakian, Barbara J., Hodges, John R., Rosser, Anne E., Lange, Klaus W., Robbins, Trevor W.
Eighteen patients with early Huntington's disease were compared with age- and IQ-matched control volunteers on tests of executive and mnemonic function taken from the Cambridge Neuropsychological...
Cell Therapy in Huntington's Disease
Dunnett, Stephen B., Rosser, Anne E.
Summary: Huntington's disease is an autosomal dominant genetic disease, which results in progressive neuronal degeneration in the neostriatum and neocortex, and associated functional impairments in...
Cell Therapy in Huntington's Disease
Dunnett, Stephen B., Rosser, Anne E.
Summary: Huntington's disease is an autosomal dominant genetic disease, which results in progressive neuronal degeneration in the neostriatum and neocortex, and associated functional impairments in...
The survival of neural precursor cell grafts is influenced by in vitro expansion
Zietlow, Rike, Pekarik, Vladimir, Armstrong, Richard JE, Tyers, Pamela, Dunnett, Stephen B, Rosser, Anne E
Embryonic neural precursor cells (ENPs) provide a potential alternative for transplantation in neurodegenerative diseases, as they can be expanded in culture, avoiding many of the practical obstacles...
Potential cellular and regenerative approaches for the treatment of Parkinson’s disease
Lane, Emma L, Handley, Olivia J, Rosser, Anne E, Dunnett, Stephen B
Parkinson’s disease is most commonly treated with a range of pharmacotherapeutics, with the more recent introduction of surgical techniques including deep-brain stimulation. These have limited...