Anne H. Schmieder

Minute dosages of ανβ3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits

Winter, Patrick M., Schmieder, Anne H., Caruthers, Shelton D., Keene, Jeffery L., Zhang, Huiying, Wickline, Samuel A., ...

Fumagillin suppresses angiogenesis in cancer models and clinical trials, but it is associated with neurotoxicity at systemic doses. In this study, ανβ3-targeted fumagillin nanoparticles were used...