Anne Hagemeijer

Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation (2008)

Quelen, Cathy, Rosati, Roberto, La Starza, Roberta, Bastard, Christian, ...

Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;...

EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22 (2008)

De Weer, An, Speleman, Franki, Cauwelier, Barbara, Van Roy, Nadine, Yigit, Nurten, Verhasselt, Bruno, ...

Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular...

EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22 (2008)

De Weer, An, Speleman, Franki, Cauwelier, Barbara, Van Roy, Nadine, Yigit, Nurten, Verhasselt, Bruno, ...

Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular...

Five members of the CEBP transcription factor family are targeted by recurrent IGH-translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) (2007)

Akasaka, Takashi, Balasas, Theodore, Russell, Lisa J., Sugimoto, Kei-ji, Majid, Aneela, Walewska, Renata, ...

CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid leukemogenesis. Mutations of CEBPA are found in a...

EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements (2006)

Dastugue, Nicole, Vandesompele, Jo, Cauwelier, Barbara, Yigit, Nurten, ...

In contrast to the well-documented involvement of EVI1 in various 3q26 aberrations, the transcriptional status of EVI1 in rare recurrent or sporadic 3q26 chromosomal defects has remained largely...

MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene (2006)

Storlazzi, Clelia Tiziana, Fioretos, Thoas, Surace, Cecilia, Lonoce, Angelo, Mastrorilli, Angela, Strömbeck, Bodil, ...

Double minutes (dmin)—circular, extra-chromosomal amplifications of specific acentric DNA fragments—are relatively frequent in malignant disorders, particularly in solid tumors. In acute myeloid...

MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene (2006)

Storlazzi, Clelia Tiziana, Fioretos, Thoas, Surace, Cecilia, Lonoce, Angelo, Mastrorilli, Angela, Strömbeck, Bodil, ...

Double minutes (dmin) - circular, extrachromosomal amplifications of specific acentric DNA fragments - are relatively frequent in malignant disorders, particularly in solid tumors. In acute myeloid...

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats. (2004)

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Abstract is not available

A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23). (2003)

Barmpouti, Aikaterini, Höglund, Mattias, Johansson, Bertil, Lassen, Carin, Nilsson, Per-Gunnar, Hagemeijer, Anne, ...

Abstract is not available

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. (2002)

Barbouti, Aikaterini, Johansson, Bertil, Höglund, Mattias, Mauritzson, Nils, Strömbeck, Bodil, Nilsson, Per-Gunnar, ...

During the initial indolent chronic phase of chronic myeloid leukemia (CML), the t(9;22)(q34;q11), resulting in the Philadelphia chromosome (Ph), is usually the sole cytogenetic anomaly, but as the...

Characterization of three human malignant mesothelioma cell lines (1989)

Versnel, Marjan A., Hoogsteden, Henk C., Hagemeijer, Anne, Bouts, Monique J., Ramaekers, Frans C.S.

The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin

Helbling, Daniel, Mueller, Beatrice U., Timchenko, Nikolai A., Hagemeijer, Anne, Jotterand, Martine, Meyer-Monard, Sandrine, ...

The leukemic fusion gene AML1-MDS1-EVI1 (AME) encodes a chimeric transcription factor that results from the t(3,21)(q26;q22) translocation seen in patients with acute myeloid leukemia, with...

The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin

Helbling, Daniel, Mueller, Beatrice U., Timchenko, Nikolai A., Hagemeijer, Anne, Jotterand, Martine, Meyer-Monard, Sandrine, ...

The leukemic fusion gene AML1-MDS1-EVI1 (AME) encodes a chimeric transcription factor that results from the t(3,21)(q26;q22) translocation seen in patients with acute myeloid leukemia, with...

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Although a great deal of information has accumulated regarding the mechanisms underlying constitutional DNA rearrangements associated with inherited disorders, virtually nothing is known about the...

Comparative Genomic Hybridization Pattern Distinguishes T-Cell/Histiocyte-Rich B-Cell Lymphoma from Nodular Lymphocyte Predominance Hodgkin’s Lymphoma

Franke, Sabine, Wlodarska, Iwona, Maes, Brigitte, Vandenberghe, Peter, Achten, Ruth, Hagemeijer, Anne, ...

Several lines of evidences suggest that T cell/histiocyte-rich B-cell lymphoma (T/HRBCL) represents an aggressive variant of the clinically indolent entity nodular lymphocyte predominance Hodgkin’s...

Complex Genomic Rearrangement of ALK Loci Associated with Integrated Human Epstein-Barr Virus in a Post-Transplant Myogenic Liver Tumor

Debiec-Rychter, Maria, Croes, Romaric, De Vos, Rita, Marynen, Peter, Roskams, Tania, Hagemeijer, Anne, ...

Epstein-Barr virus (EBV) is a ubiquitous viral agent, well known to be associated with lymphoid, epithelial, and smooth-muscle malignancies in immunocompromised individuals. This report describes a...

Frequent NF2 Gene Transcript Mutations in Sporadic Meningiomas and Vestibular Schwannomas

Deprez, Ronald H. Lekanne, Bianchi, Albert B., Groen, Nicole A., Seizinger, Bernd R., Hagemeijer, Anne, Van Drunen, Ellen, ...

The gene for the hereditary disorder neurofibromatosis type 2 (NF2), which predisposes for benign CNS tumors such as vestibular schwannomas and meningiomas, has been assigned to chromosome 22 and...

Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

Bousquet, Marina, Quelen, Cathy, Rosati, Roberto, La Starza, Roberta, Bastard, Christian, ...

Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The...