Anne Simonsen

Printed in Great Britain © The Company of Biologists Limited 1997 (2008)

Anne Simonsen, Espen Stang, Bjørn Bremnes, Målfrid Røe, Kristian Prydz, Oddmund Bakke

Epithelial cells have been found to express MHC class II molecules in vivo and are able to perform class II-restricted antigen presentation. The precise intracellular localization of these molecules...

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008)

Spanel-Borowski, Katharina, Smith, Mark A., Simone, Cristiano, Simonsen, Anne, Simon, Hans-Uwe, ...

Research in autophagy continues to accelerate, and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring...

Intracellular distribution of the MHC class II molecules and the associated invariant chain (li) in different cell lines (1993)

Simonsen, Anne, Momburg, Frank, Drexler, Johannes, Hämmerling, Günther J., Bakke, Oddmund, MacDonald, R.

Intracellular localization and routing of MHC class II molecules and the associated invariant chain (II) were studied using rat-2 cells and HeLa cells stably transfected with the murine class II...

Genetic Modifiers of the Drosophila Blue Cheese Gene Link Defects in Lysosomal Transport With Decreased Life Span and Altered Ubiquitinated-Protein Profiles

Simonsen, Anne, Cumming, Robert C., Lindmo, Karine, Galaviz, Vanessa, Cheng, Susan, Rusten, Tor Erik, ...

Defects in lysosomal trafficking pathways lead to decreased cell viability and are associated with progressive disorders in humans. Previously we have found that loss-of-function (LOF) mutations in...

Phosphoinositides and phagocytosis

Gillooly, David J., Simonsen, Anne, Stenmark, Harald

Phosphoinositide 3 kinases (PI3Ks)* are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that...

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

Filimonenko, Maria, Stuffers, Susanne, Raiborg, Camilla, Yamamoto, Ai, Malerød, Lene, Fisher, Elizabeth M.C., ...

The endosomal sorting complexes required for transport (ESCRTs) are required to sort integral membrane proteins into intralumenal vesicles of the multivesicular body (MVB). Mutations in the ESCRT-III...

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

Nezis, Ioannis P., Simonsen, Anne, Sagona, Antonia P., Finley, Kim, Gaumer, Sébastien, Contamine, Didier, ...

p62 has been proposed to mark ubiquitinated protein bodies for autophagic degradation. We report that the Drosophila melanogaster p62 orthologue, Ref(2)P, is a regulator of protein aggregation in the...

Self-eating from an ER-associated cup

Simonsen, Anne, Stenmark, Harald

Since the first morphological description of autophagosomes in the early 1960s, two critical questions have been a matter of intense investigation and debate: what is the origin of the autophagosomal...