Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
Campese, Antonio F., Garbe, Annette I., Zhang, Fangrong, Grassi, Fabio, Screpanti, Isabella, Von Boehmer, Harald
Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required...
Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
Garbe, Annette I., Krueger, Andreas, Gounari, Fotini, Zúñiga-Pflücker, Juan Carlos, Von Boehmer, Harald
Thymic precursors expressing the pre–T cell receptor (TCR), the γδTCR, or the αβTCR can all enter the CD4+8+ αβ lineage, albeit with different efficacy. Here it is shown that proliferation...
Aifantis, Iannis, Bassing, Craig H., Garbe, Annette I., Sawai, Katie, Alt, Frederick W., Von Boehmer, Harald
It is well established that the pre–T cell receptor for antigen (TCR) is responsible for efficient expansion and differentiation of thymocytes with productive TCRβ rearrangements. However, Ptcra-...
Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands
Krueger, Andreas, Garbe, Annette I., Von Boehmer, Harald
Despite many efforts, the nature of thymic immigrants that give rise to T cells has remained obscure, especially since it became known that extrathymic lineage-negative, Sca-1–positive, c-kit high...
T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis
Kreslavsky, Taras, Garbe, Annette I., Krueger, Andreas, Von Boehmer, Harald
αβ and γδ T cell lineages develop in the thymus from a common precursor. It is unclear at which stage of development commitment to these lineages takes place and in which way T cell receptor...