Prows, Daniel R., Hafertepen, Amanda P., Winterberg, Abby V., Gibbons, William J., Wesselkamper, Scott C., Singer, Jonathan B., ...
Acute lung injury (ALI) is a devastating condition resulting from diverse causes. Genetic studies of human populations indicate that ALI is a complex disease with substantial phenotypic variance,...
Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. (2008)
Shao, Haifeng, Burrage, Lindsay C., Sinasac, David S., Hill, Annie E., Ernest, Sheila R., O'Brien, William, ...
The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the...
Genetic background determines response to hemostasis and thrombosis (2006)
Hoover-Plow, Jane, Shchurin, Aleksey, Hart, Erika, Sha, Jingfeng, Hill, Annie E, Singer, Jonathan B, ...
Abstract Background Thrombosis is the fatal and disabling consequence of cardiovascular diseases, the leading cause of mortality and morbidity in Western countries. Two inbred mouse strains, C57BL/6J...
Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice. (2005)
Singer, Jonathan B., Hill, Annie E., Nadeau, Joseph H., Lander, Eric S.
Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J...
Petryshen, Tracey L., Kirby, Andrew, Hammer, Ronald P., Purcell, Shaun, O'Leary, Sinead B., Singer, Jonathan B., ...
Prepulse inhibition (PPI) of acoustic startle is a genetically complex quantitative phenotype of considerable medical interest due to its impairment in psychiatric disorders such as schizophrenia. To...
Poirier, Christophe, Qin, Yangjun, Adams, Carolyn P., Anaya, Yanett, Singer, Jonathan B., Hill, Annie E., ...
The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific...
Poirier, Christophe, Qin, Yangjun, Adams, Carolyn P., Anaya, Yanett, Singer, Jonathan B., Hill, Annie E., ...
The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific...
Mapping Quantitative Trait Loci for Anxiety in Chromosome Substitution Strains of Mice
Singer, Jonathan B., Hill, Annie E., Nadeau, Joseph H., Lander, Eric S.
Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J...
Petryshen, Tracey L., Kirby, Andrew, Hammer, Ronald P., Purcell, Shaun, O'Leary, Sinead B., Singer, Jonathan B., ...
Prepulse inhibition (PPI) of acoustic startle is a genetically complex quantitative phenotype of considerable medical interest due to its impairment in psychiatric disorders such as schizophrenia. To...
Genetic background determines response to hemostasis and thrombosis
Hoover-Plow, Jane, Shchurin, Aleksey, Hart, Erika, Sha, Jingfeng, Hill, Annie E, Singer, Jonathan B, ...
Poirier, Christophe, Qin, Yangjun, Adams, Carolyn P., Anaya, Yanett, Singer, Jonathan B., Hill, Annie E., ...
The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific...
Mapping Quantitative Trait Loci for Anxiety in Chromosome Substitution Strains of Mice
Singer, Jonathan B., Hill, Annie E., Nadeau, Joseph H., Lander, Eric S.
Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J...
Petryshen, Tracey L., Kirby, Andrew, Hammer, Ronald P., Purcell, Shaun, O'Leary, Sinead B., Singer, Jonathan B., ...
Prepulse inhibition (PPI) of acoustic startle is a genetically complex quantitative phenotype of considerable medical interest due to its impairment in psychiatric disorders such as schizophrenia. To...
Genetic background determines response to hemostasis and thrombosis
Hoover-Plow, Jane, Shchurin, Aleksey, Hart, Erika, Sha, Jingfeng, Hill, Annie E, Singer, Jonathan B, ...
Reciprocal Congenic Lines of Mice Capture the Aliq1 Effect on Acute Lung Injury Survival Time
Prows, Daniel R., Hafertepen, Amanda P., Winterberg, Abby V., Gibbons, William J., Wesselkamper, Scott C., Singer, Jonathan B., ...
Acute lung injury (ALI) is a devastating condition resulting from diverse causes. Genetic studies of human populations indicate that ALI is a complex disease with substantial phenotypic variance,...
Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis
Shao, Haifeng, Burrage, Lindsay C., Sinasac, David S., Hill, Annie E., Ernest, Sheila R., O'Brien, William, ...
The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the...
Resistance to diet-induced obesity in mice with a single substituted chromosome
Buchner, David A., Burrage, Lindsay C., Hill, Annie E., Yazbek, Soha N., O'Brien, William E., Croniger, Colleen M., ...
Obesity and its comorbidities are taking an increasing toll on human health. Key pathways that were identified with single gene variants in humans and model organisms have led to improved...