OUGHTON, JULIE A., PEREIRA, CLIFFORD B., DEKREY, GREG K., COLLIER, JOHN M., FRANK, ANTHONY A., KERKVLIET, NANCY I.
A mouse model was used to identify potential biomarkers of exposure to the environmental contaminant 2,3,7,8-tetrachiorodibenzo-p-dioxin (TCDD). Female C57B1/6 mice were treated weekly with 0.2...
Frank, Anthony A., Collier, John M., Forsyth, Carol A., Oughton, Julie A., Kerkvliet, Nancy I.
N-Methyl-N-nitrosourea (MNU) induces thymic lymphosarcoma in numerous mouse strains. We determined the neoplastic phenotype induced by MNU in 20 C57B1/6J mice. Eleven neoplasms were composed of cells...
Wilson, Vincent L., Foiles, Peter G., Chung, Fung-Lung, Povey, Andrew C., Frank, Anthony A., Harris, Curtis C.
People are constantiy being exposed to toxic and carcinogenic aldehydes. However, little is actually known about the mechanisms underlying the toxic and carcinogenic effects of these aldehydes on...
Transient Loss of Resistance to Pulmonary Tuberculosis in p47phox−/− Mice
Cooper, Andrea M., Segal, Brahm H., Frank, Anthony A., Holland, Steven M., Orme, Ian M.
Mycobacterium tuberculosis is an important respiratory pathogen the growth of which is controlled primarily by cytokine-activated macrophages. One of the principal mediators of this control is nitric...
Turner, Joanne, Rhoades, Elizabeth R., Keen, Marc, Belisle, John T., Frank, Anthony A., Orme, Ian M.
Two vaccine formulations previously shown to induce protective immunity in mice and prevention of long-term necrosis in guinea pigs were tested as potential immunotherapeutic vaccines in mice earlier...
Saunders, Bernadette M., Frank, Anthony A., Orme, Ian M., Cooper, Andrea M.
Immunity to Mycobacterium tuberculosis is dependent upon the generation of a protective gamma interferon (IFN-γ)-producing T-cell response. Recent studies have suggested that interleukin-6 (IL-6) is...
Turner, Oliver C., Roberts, Alan D., Frank, Anthony A., Phalen, Susan W., McMurray, David M., Content, Jean, ...
In this study, the hsp60 and hsp70 heat shock protein antigens of Mycobacterium tuberculosis were tested as potential vaccine candidates, using purified recombinant protein antigens or antigens...
Boosting Vaccine for Tuberculosis
Brooks, Jason V., Frank, Anthony A., Keen, Marc A., Bellisle, John T., Orme, Ian M.
An effective new vaccine for the control of tuberculosis is badly needed. While current research attempts to improve vaccination are concentrating on new prophylactic or immunotherapeutic vaccines,...
Johnson, Christine M., Cooper, Andrea M., Frank, Anthony A., Orme, Ian M.
It remains unknown whether the expression of cell-mediated protective immunity and the capacity to mount a delayed-type hypersensitivity (DTH) reaction in tuberculosis infection represent two...
Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis
Baldwin, Susan L., D’Souza, Celine, Roberts, Alan D., Kelly, Brian P., Frank, Anthony A., Lui, Margaret A., ...
The results of this study provide the first evidence that two completely separate vaccine approaches, one based on a subunit vaccine consisting of a mild adjuvant admixed with purified culture...
Role of γδ T Cells in Immunopathology of Pulmonary Mycobacterium avium Infection in Mice
Saunders, Bernadette M., Frank, Anthony A., Cooper, Andrea M., Orme, Ian M.
Several studies have shown that γδ T cells influence granuloma development after infection with intracellular pathogens. The role of γδ T cells in controlling the influx of inflammatory cells...
Turner, Joanne, Frank, Anthony A., Orme, Ian M.
During the natural aging process the immune system undergoes many alterations. In particular, both the CD4 and CD8 T-cell compartments become compromised, and these changes have serious implications...
Turner, Joanne, Dobos, Karen M., Keen, Marc A, Frank, Anthony A., Ehlers, Stefan, Orme, Ian M., ...
Mice that were transgenic for a T-cell receptor (TCR) specific for ovalbumin peptide323-339 (DO11.10) were able to survive an infection with Mycobacterium tuberculosis for approximately 80 days. This...
Transient Loss of Resistance to Pulmonary Tuberculosis in p47phox−/− Mice
Cooper, Andrea M., Segal, Brahm H., Frank, Anthony A., Holland, Steven M., Orme, Ian M.
Mycobacterium tuberculosis is an important respiratory pathogen the growth of which is controlled primarily by cytokine-activated macrophages. One of the principal mediators of this control is nitric...
Turner, Joanne, Rhoades, Elizabeth R., Keen, Marc, Belisle, John T., Frank, Anthony A., Orme, Ian M.
Two vaccine formulations previously shown to induce protective immunity in mice and prevention of long-term necrosis in guinea pigs were tested as potential immunotherapeutic vaccines in mice earlier...
Saunders, Bernadette M., Frank, Anthony A., Orme, Ian M., Cooper, Andrea M.
Immunity to Mycobacterium tuberculosis is dependent upon the generation of a protective gamma interferon (IFN-γ)-producing T-cell response. Recent studies have suggested that interleukin-6 (IL-6) is...
Turner, Oliver C., Roberts, Alan D., Frank, Anthony A., Phalen, Susan W., McMurray, David M., Content, Jean, ...
In this study, the hsp60 and hsp70 heat shock protein antigens of Mycobacterium tuberculosis were tested as potential vaccine candidates, using purified recombinant protein antigens or antigens...
Boosting Vaccine for Tuberculosis
Brooks, Jason V., Frank, Anthony A., Keen, Marc A., Bellisle, John T., Orme, Ian M.
An effective new vaccine for the control of tuberculosis is badly needed. While current research attempts to improve vaccination are concentrating on new prophylactic or immunotherapeutic vaccines,...
Johnson, Christine M., Cooper, Andrea M., Frank, Anthony A., Orme, Ian M.
It remains unknown whether the expression of cell-mediated protective immunity and the capacity to mount a delayed-type hypersensitivity (DTH) reaction in tuberculosis infection represent two...
Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis
Baldwin, Susan L., D’Souza, Celine, Roberts, Alan D., Kelly, Brian P., Frank, Anthony A., Lui, Margaret A., ...
The results of this study provide the first evidence that two completely separate vaccine approaches, one based on a subunit vaccine consisting of a mild adjuvant admixed with purified culture...
Role of γδ T Cells in Immunopathology of Pulmonary Mycobacterium avium Infection in Mice
Saunders, Bernadette M., Frank, Anthony A., Cooper, Andrea M., Orme, Ian M.
Several studies have shown that γδ T cells influence granuloma development after infection with intracellular pathogens. The role of γδ T cells in controlling the influx of inflammatory cells...
Turner, Joanne, Frank, Anthony A., Orme, Ian M.
During the natural aging process the immune system undergoes many alterations. In particular, both the CD4 and CD8 T-cell compartments become compromised, and these changes have serious implications...
Turner, Joanne, Dobos, Karen M., Keen, Marc A, Frank, Anthony A., Ehlers, Stefan, Orme, Ian M., ...
Mice that were transgenic for a T-cell receptor (TCR) specific for ovalbumin peptide323-339 (DO11.10) were able to survive an infection with Mycobacterium tuberculosis for approximately 80 days. This...