The role of the cGMP-dependent protein kinase in development of the malaria parasite (2009)
McRobert, Louisa, Taylor, Helen M, Taylor, Cathy J, Deng, Wensheng, Moon, Robert W, Fivelman, Quinton L, ...
No abstract available.
Blythe, Jane E, Niang, Makhtar, Marsh, Kevin, Holder, Anthony A, Langhorne, Jean, Preiser, Peter R
Abstract Background The evasion of host immune response by the human malaria parasite Plasmodium falciparum has been linked to expression of a range of variable antigens on the infected erythrocyte...
Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion (2007)
Alfred Cortés, Celine Carret, Osamu Kaneko, Alasdair Ivens, Anthony A. Holder
The process of erythrocyte invasion by merozoites of Plasmodium falciparum involves multiple steps, including the formation of a moving junction between parasite and host cell, and it is...
The Importance of Human FcγRI in Mediating Protection to Malaria (2007)
Richard S. McIntosh, Jianguo Shi, Richard M. Jennings, Jonathan C. Chappel, Tim Smith, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
Importance of human FcyRI in mediating protection to malaria (2007)
McIntosh, Richard S., Shi, Jianguo, Jennings, Richard M., Chappel, Jonathan C., Smith, Tim, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
The importance of human FcyRI in mediating protection to malaria (2007)
McIntosh, Richard S., Shi, Jianguo, Jennings, Richard M., Chappel, Jonathan C., Smith, Tim, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
Global Analysis of Transcript and Protein Levels Across the Plasmodium falciparum Life Cycle (2006)
LeRoch, Karine G., Johnson, Jeffrey R., Florens, Laurence, Zhou, Yingyao, Santrosyan, Audrey, Grainger, Munira, ...
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein...
falciparum antigens by antigenic analysis of genomic and proteomic (2006)
Z. Bozdech, M. Llinas, B. L. Pulliam, E. D. Wong, J. Zhu, Z. Bozdech, ...
plasmodium
Holly E. Trueman, J. Dale Raine, Laurence Florens, Johannes T. Dessens, Jacqui Mendoza, Jeffrey Johnson, ...
Using bioinformatic, proteomic, immunofluorescence, and genetic cross methods, we have functionally characterized a family of putative parasite ligands as potential mediators of cell–cell...
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle (2004)
Le Roch, Karine G., Johnson, Jeffrey R., Florens, Laurence, Zhou, Yingyao, Santrosyan, Andrey, Grainger, Munira, ...
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein...
Fievet, Nadine, Tami, Germaine, Maubert, Bertrand, Moussa, Marlène, Shaw, Ian K, Cot, Michel, ...
Abstract Background Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum -infected erythrocytes in placental intervillous spaces. Placental parasites express a specific...
Ahlborg, Niklas, Ling, Irene T., Holder, Anthony A., Riley, Eleanor M.
The degree of protection against Plasmodium yoelii asexual blood stages induced by immunization of mice with the 19-kDa region of merozoite surface protein 1 (MSP119) is H-2 dependent. As a strategy...
Narum, David L., Ogun, Solabomi A., Thomas, Alan W., Holder, Anthony A.
We have purified apical merozoite antigen 1 (AMA-1) from extracts of red blood cells infected with the rodent malaria parasite Plasmodium yoelii yoelii YM. When used to immunize mice, the protein...
Mota, Maria M., Brown, K. Neil, Do Rosário, Virgilio E., Holder, Anthony A., Jarra, William
In regions where malaria is endemic, inhabitants remain susceptible to repeated reinfection as they develop and maintain clinical immunity. This immunity includes responses to surface-exposed...
Taylor, Helen M., Triglia, Tony, Thompson, Jenny, Sajid, Mohammed, Fowler, Ruth, Wickham, Mark E., ...
The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte...
Mota, Maria M., Jarra, William, Hirst, Elizabeth, Patnaik, Pradeep K., Holder, Anthony A.
Adherence of erythrocytes infected with Plasmodium falciparum to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis....
Spencer Valero, Lilian M., Ogun, Solabomi A., Fleck, Suzanne L., Ling, Irene T., Scott-Finnigan, Terry J., Blackman, Michael J., ...
We have produced monoclonal antibodies against Plasmodium yoelii merozoite surface protein 1 (MSP-1) and have assessed their ability to suppress blood stage parasitemia by passive immunization. Six...
Mota, Maria M., Brown, K. Neil, Holder, Anthony A., Jarra, William
CBA/Ca mice infected with 5 × 104 Plasmodium chabaudi chabaudi AS-parasitized erythrocytes experience acute but self-limiting infections of relatively short duration. Parasitemia peaks (∼40%...
Ahlborg, Niklas, Ling, Irene T., Howard, Wendy, Holder, Anthony A., Riley, Eleanor M.
Vaccination of mice with the 42-kDa region of Plasmodium yoelii merozoite surface protein 1 (MSP142) or its 19-kDa C-terminal processing product (MSP119) can elicit protective antibody responses in...
Nwuba, Roseangela I., Sodeinde, Olugbemiro, Anumudu, Chiaka I., Omosun, Yusuf O., Odaibo, Alexander B., Holder, Anthony A., ...
Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this...
Taylor, Helen M., Grainger, Munira, Holder, Anthony A.
The PfRH protein family of Plasmodium falciparum is implicated in erythrocyte invasion. Here we report variations in the sequence, transcription, and protein expression of four different members of...
Okech, Brenda A., Corran, Patrick H., Todd, James, Joynson-Hicks, Amy, Uthaipibull, Chairat, Egwang, Thomas G., ...
Antibodies to the C terminus of the Plasmodium falciparum merozoite surface protein, PfMSP-119, may inhibit merozoite invasion or block the effects of inhibitory antibodies. Here, using a competition...
Amino-Acid Sequence of NADP-Specific Glutamate Dehydrogenase of Neurospora crassa
Wootton, John C., Chambers, Geoffrey K., Holder, Anthony A., Baron, Andrew J., Taylor, John G., Fincham, John R. S., ...
A tentative primary structure of the NADP-specific glutamate dehydrogenase [L-glutamate: NADP oxidoreductase (deaminating), EC 1.4.1.4] from Neurospora crassa has been determined. The proposed...
Corran, Patrick H., O'Donnell, Rebecca A., Todd, Jim, Uthaipibull, Chairat, Holder, Anthony A., Crabb, Brendan S., ...
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-119)-specific erythrocyte invasion...
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Le Roch, Karine G., Johnson, Jeffrey R., Florens, Laurence, Zhou, Yingyao, Santrosyan, Andrey, Grainger, Munira, ...
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein...
Darko, Christian A., Angov, Evelina, Collins, William E., Bergmann-Leitner, Elke S., Girouard, Autumn S., Hitt, Stacy L., ...
A 42-kDa fragment from the C terminus of major merozoite surface protein 1 (MSP1) is among the leading malaria vaccine candidates that target infection by asexual erythrocytic-stage malaria...
Pinder, Margaret, Sutherland, Colin J., Sisay-Joof, Fatoumatta, Ismaili, Jamila, McCall, Matthew B. B., Ord, Rosalyn, ...
We examined the hypothesis that recovery from uncomplicated malaria in patients carrying drug-resistant Plasmodium falciparum is a measure of acquired functional immunity and may therefore be...
Ahlborg, Niklas, Ling, Irene T., Holder, Anthony A., Riley, Eleanor M.
The degree of protection against Plasmodium yoelii asexual blood stages induced by immunization of mice with the 19-kDa region of merozoite surface protein 1 (MSP119) is H-2 dependent. As a strategy...
Narum, David L., Ogun, Solabomi A., Thomas, Alan W., Holder, Anthony A.
We have purified apical merozoite antigen 1 (AMA-1) from extracts of red blood cells infected with the rodent malaria parasite Plasmodium yoelii yoelii YM. When used to immunize mice, the protein...
Mota, Maria M., Brown, K. Neil, Do Rosário, Virgilio E., Holder, Anthony A., Jarra, William
In regions where malaria is endemic, inhabitants remain susceptible to repeated reinfection as they develop and maintain clinical immunity. This immunity includes responses to surface-exposed...
Taylor, Helen M., Triglia, Tony, Thompson, Jenny, Sajid, Mohammed, Fowler, Ruth, Wickham, Mark E., ...
The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte...
Mota, Maria M., Jarra, William, Hirst, Elizabeth, Patnaik, Pradeep K., Holder, Anthony A.
Adherence of erythrocytes infected with Plasmodium falciparum to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis....
Spencer Valero, Lilian M., Ogun, Solabomi A., Fleck, Suzanne L., Ling, Irene T., Scott-Finnigan, Terry J., Blackman, Michael J., ...
We have produced monoclonal antibodies against Plasmodium yoelii merozoite surface protein 1 (MSP-1) and have assessed their ability to suppress blood stage parasitemia by passive immunization. Six...
Mota, Maria M., Brown, K. Neil, Holder, Anthony A., Jarra, William
CBA/Ca mice infected with 5 × 104 Plasmodium chabaudi chabaudi AS-parasitized erythrocytes experience acute but self-limiting infections of relatively short duration. Parasitemia peaks (∼40%...
Ahlborg, Niklas, Ling, Irene T., Howard, Wendy, Holder, Anthony A., Riley, Eleanor M.
Vaccination of mice with the 42-kDa region of Plasmodium yoelii merozoite surface protein 1 (MSP142) or its 19-kDa C-terminal processing product (MSP119) can elicit protective antibody responses in...
Nwuba, Roseangela I., Sodeinde, Olugbemiro, Anumudu, Chiaka I., Omosun, Yusuf O., Odaibo, Alexander B., Holder, Anthony A., ...
Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this...
Taylor, Helen M., Grainger, Munira, Holder, Anthony A.
The PfRH protein family of Plasmodium falciparum is implicated in erythrocyte invasion. Here we report variations in the sequence, transcription, and protein expression of four different members of...
Okech, Brenda A., Corran, Patrick H., Todd, James, Joynson-Hicks, Amy, Uthaipibull, Chairat, Egwang, Thomas G., ...
Antibodies to the C terminus of the Plasmodium falciparum merozoite surface protein, PfMSP-119, may inhibit merozoite invasion or block the effects of inhibitory antibodies. Here, using a competition...
Amino-Acid Sequence of NADP-Specific Glutamate Dehydrogenase of Neurospora crassa
Wootton, John C., Chambers, Geoffrey K., Holder, Anthony A., Baron, Andrew J., Taylor, John G., Fincham, John R. S., ...
A tentative primary structure of the NADP-specific glutamate dehydrogenase [L-glutamate: NADP oxidoreductase (deaminating), EC 1.4.1.4] from Neurospora crassa has been determined. The proposed...
Corran, Patrick H., O'Donnell, Rebecca A., Todd, Jim, Uthaipibull, Chairat, Holder, Anthony A., Crabb, Brendan S., ...
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-119)-specific erythrocyte invasion...
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Le Roch, Karine G., Johnson, Jeffrey R., Florens, Laurence, Zhou, Yingyao, Santrosyan, Andrey, Grainger, Munira, ...
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein...
Darko, Christian A., Angov, Evelina, Collins, William E., Bergmann-Leitner, Elke S., Girouard, Autumn S., Hitt, Stacy L., ...
A 42-kDa fragment from the C terminus of major merozoite surface protein 1 (MSP1) is among the leading malaria vaccine candidates that target infection by asexual erythrocytic-stage malaria...
Pinder, Margaret, Sutherland, Colin J., Sisay-Joof, Fatoumatta, Ismaili, Jamila, McCall, Matthew B. B., Ord, Rosalyn, ...
We examined the hypothesis that recovery from uncomplicated malaria in patients carrying drug-resistant Plasmodium falciparum is a measure of acquired functional immunity and may therefore be...
Narum, David L., Ogun, Solabomi A., Batchelor, Adrian H., Holder, Anthony A.
During malaria parasite invasion of red blood cells, merozoite proteins bind receptors on the surface of the erythrocyte. Two candidate Plasmodium yoelii adhesion proteins are apical membrane antigen...
The Importance of Human FcγRI in Mediating Protection to Malaria
McIntosh, Richard S, Shi, Jianguo, Jennings, Richard M, Chappel, Jonathan C, Smith, Tim, ...
The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium...
Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion
Cortés, Alfred, Carret, Celine, Kaneko, Osamu, Ivens, Alasdair, Holder, Anthony A
The process of erythrocyte invasion by merozoites of Plasmodium falciparum involves multiple steps, including the formation of a moving junction between parasite and host cell, and it is...
Faber, Bart W., Remarque, Edmond J., Morgan, William D., Kocken, Clemens H. M., Holder, Anthony A., Thomas, Alan W.
We show that the smallest module of Plasmodium falciparum AMA1 (PfAMA1) that can be expressed in the yeast Pichia pastoris while retaining the capacity to induce high levels of parasite-inhibitory...
Guevara Patiño, José A., Holder, Anthony A., McBride, Jana S., Blackman, Michael J.
Merozoite surface protein–1 (MSP-1) of the human malaria parasite Plasmodium falciparum undergoes at least two endoproteolytic cleavage events during merozoite maturation and release, and...
Dluzewski, Anton R., Ling, Irene T., Hopkins, John M., Grainger, Munira, Margos, Gabriele, Mitchell, Graham H., ...
Plasmodium falciparum Merozoite Surface Protein 1 (MSP1) is synthesized during schizogony as a 195-kDa precursor that is processed into four fragments on the parasite surface. Following a second...
Blythe, Jane E., Yam, Xue Yan, Kuss, Claudia, Bozdech, Zbynek, Holder, Anthony A., Marsh, Kevin, ...
The human parasite Plasmodium falciparum has the potential to express a vast repertoire of variant proteins on the surface of the infected red blood cell (iRBC). Variation in the expression pattern...
Ogun, Solabomi A., Dumon-Seignovert, Laurence, Marchand, Jean-Baptiste, Holder, Anthony A., Hill, Fergal
Highly purified protein antigens are usually poor immunogens; in practice, adjuvants are needed to obtain satisfactory immune responses. Plasmodium yoelii 19-kDa merozoite surface protein 1 (MSP119)...
The Motor Complex of Plasmodium falciparum: PHOSPHORYLATION BY A CALCIUM-DEPENDENT PROTEIN KINASE*
Green, Judith L., Rees-Channer, Roxanne R., Howell, Stephen A., Martin, Stephen R., Knuepfer, Ellen, Taylor, Helen M., ...
Calcium-dependent protein kinases (CDPKs) of Apicomplexan parasites are crucial for the survival of the parasite throughout its life cycle. CDPK1 is expressed in the asexual blood stages of the...
Arnot, David E., Cavanagh, David R., Remarque, Edmond J., Creasey, Alison M., Sowa, Mercy P. K., Morgan, William D., ...
Immunogenicity testing of Plasmodium falciparum antigens being considered as malaria vaccine candidates was undertaken in rabbits. The antigens compared were recombinant baculovirus MSP-119 and five...
Narum, David L., Nguyen, Vu, Zhang, Yanling, Glen, Jacqueline, Shimp, Richard L., Lambert, Lynn, ...
Previously, we identified a Plasmodium yoelii YM 140-kDa merozoite protein, designated PyP140, which formed a complex with apical membrane antigen 1 (AMA1). Furthermore, we produced a nonprotective...
Kadekoppala, Madhusudan, O'Donnell, Rebecca A., Grainger, Munira, Crabb, Brendan S., Holder, Anthony A.
Merozoite surface proteins have been implicated in the initial attachment to the host red blood cell membrane that begins the process of invasion, an important step in the life cycle of the malaria...