Anthony Mittermaier

Center of Excellence and Departments of Medical (2008)

Oscar Millet, Anthony Mittermaier, David Baker, Lewis E. Kay, Genetics Biochemistry

The structural and dynamic properties of proteins are determined by their primary amino acid sequence. Elucidation of the rules that govern this relationship is of immense practical and

Side chain burial and hydrophobic core packing in protein folding transition states (2008)

Farber, Patrick J., Mittermaier, Anthony

A critical step in the folding pathway of globular proteins is the formation of a tightly packed hydrophobic core. Several mutational studies have addressed the question of whether tight packing...

Protein stabilization by specific binding of guanidinium to a functional arginine-binding surface on an SH3 domain (2006)

Zarrine-Afsar, Arash, Mittermaier, Anthony, Kay, Lewis E., Davidson, Alan R.

Guanidinium hydrochloride (GuHCl) at low concentrations significantly stabilizes the Fyn SH3 domain. In this work, we have demonstrated that this stabilizing effect is manifested through a dramatic...

The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase (2004)

Mittermaier, Anthony, Kay, Lewis E.

We have used 15N- and 2H-NMR spin relaxation experiments to study the response of backbone and side-chain dynamics when a leucine or valine is substituted for a completely buried phenylalanine...

Protein stabilization by specific binding of guanidinium to a functional arginine-binding surface on an SH3 domain

Zarrine-Afsar, Arash, Mittermaier, Anthony, Kay, Lewis E., Davidson, Alan R.

Guanidinium hydrochloride (GuHCl) at low concentrations significantly stabilizes the Fyn SH3 domain. In this work, we have demonstrated that this stabilizing effect is manifested through a dramatic...

The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase

Mittermaier, Anthony, Kay, Lewis E.

We have used 15N- and 2H-NMR spin relaxation experiments to study the response of backbone and side-chain dynamics when a leucine or valine is substituted for a completely buried phenylalanine...

Side chain burial and hydrophobic core packing in protein folding transition states

Farber, Patrick J., Mittermaier, Anthony

A critical step in the folding pathway of globular proteins is the formation of a tightly packed hydrophobic core. Several mutational studies have addressed the question of whether tight packing...