Anthony N. Hodder

Evidence for a common role for the serine-type plasmodium falciparum serine repeat antigen proteases : implications for vaccine and drug design (2007)

McCoubrie, Joanne E., Miller, Susanne K., Sargeant, Tobias, Good, Robert T., Hodder, Anthony N., Speed, Terence P., ...

Serine repeat antigens (SERAs) are a family of secreted "cysteine-like" proteases of Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in place of the...

Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases : implications for vaccine and drug design (2007)

McCoubrie, Joanne E., Miller, Susanne K., Sargeant, Tobias, Good, Robert T., Hodder, Anthony N., Speed, Terence P., ...

Serine repeat antigens (SERAs) are a family of secreted “cysteine-like” proteases of Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in place of the...

The Serine Repeat Antigen (SERA) Gene Family Phylogeny in Plasmodium: the Impact of GC Content, and Reconciliation of Gene and Species Trees (2004)

Bourgon, Richard, Delorenzi, Mauro, Sargeant, Tobias, Hodder, Anthony N., Crabb, Brendan S., Speed, Terence P.

Plasmodium falciparum is the parasite responsible for the most acute form of malaria in humans. Recently, the serine repeat antigen (SERA) in P. falciparum has attracted attention as a potential...

The Serine Repeat Antigen (SERA) Gene Family Phylogeny in Plasmodium: The Impact of GC Content and Reconciliation of Gene and Species Trees (2004)

Bourgon, Richard, Delorenzi, Mauro, Sargeant, Tobias, Hodder, Anthony N., Crabb, Brendan S., Speed, Terence P.

Plasmodium falciparum is the parasite responsible for the most acute form of malaria in humans. Recently, the serine repeat antigen (SERA) in P. falciparum has attracted attention as a potential...

The Serine Repeat Antigen (SERA) Gene Family Phylogeny in Plasmodium: the Impact of GC Content, and Reconciliation of Gene and Species Trees (2004)

Bourgon, Richard, Delorenzi, Mauro, Sargeant, Tobias, Hodder, Anthony N., Crabb, Brendan S., Speed, Terence P.

Plasmodium falciparum is the parasite responsible for the most acute form of malaria in humans. Recently, the serine repeat antigen (SERA) in P. falciparum has attracted attention as a potential...

Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides (2001)

Coley, Andrew M., Campanale, Naomi V., Casey, Joanne L., Hodder, Anthony N., Crewther, Pauline E., Anders, Robin F., ...

We describe an approach for the rapid mapping of epitopes within a malaria antigen using a combination of phage display techniques. Phage display of antigen fragments identifies the location of the...

Specificity of the Protective Antibody Response to Apical Membrane Antigen 1

Hodder, Anthony N., Crewther, Pauline E., Anders, Robin F.

Apical membrane antigen 1 (AMA1) is considered one of the leading candidates for inclusion in a vaccine against blood stages of Plasmodium falciparum. Although the ama1 gene is relatively conserved...

Identification of Glycosaminoglycan Binding Domains in Plasmodium falciparum Erythrocyte Membrane Protein 1 of a Chondroitin Sulfate A-Adherent Parasite

Reeder, John C., Hodder, Anthony N., Beeson, James G., Brown, Graham V.

Accumulation of Plasmodium falciparum-infected erythrocytes in the placenta is a key feature of maternal malaria. This process is mediated in part by the parasite ligand P. falciparum erythrocyte...

Plasmodium falciparum Merozoite Surface Protein 6 Is a Dimorphic Antigen

Pearce, J. Andrew, Triglia, Tony, Hodder, Anthony N., Jackson, David C., Cowman, Alan F., Anders, Robin F.

Merozoite surface protein 1 (MSP1) is a highly polymorphic Plasmodium falciparum merozoite surface protein implicated in the invasion of human erythrocytes during the asexual cycle. It forms a...

Functional Analysis of Plasmodium falciparum Apical Membrane Antigen 1 Utilizing Interspecies Domains

Healer, Julie, Triglia, Tony, Hodder, Anthony N., Gemmill, Alan W., Cowman, Alan F.

Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate whose function has not been unequivocally defined. Partial complementation of function can be achieved by...

Specificity of the Protective Antibody Response to Apical Membrane Antigen 1

Hodder, Anthony N., Crewther, Pauline E., Anders, Robin F.

Apical membrane antigen 1 (AMA1) is considered one of the leading candidates for inclusion in a vaccine against blood stages of Plasmodium falciparum. Although the ama1 gene is relatively conserved...

Identification of Glycosaminoglycan Binding Domains in Plasmodium falciparum Erythrocyte Membrane Protein 1 of a Chondroitin Sulfate A-Adherent Parasite

Reeder, John C., Hodder, Anthony N., Beeson, James G., Brown, Graham V.

Accumulation of Plasmodium falciparum-infected erythrocytes in the placenta is a key feature of maternal malaria. This process is mediated in part by the parasite ligand P. falciparum erythrocyte...

Plasmodium falciparum Merozoite Surface Protein 6 Is a Dimorphic Antigen

Pearce, J. Andrew, Triglia, Tony, Hodder, Anthony N., Jackson, David C., Cowman, Alan F., Anders, Robin F.

Merozoite surface protein 1 (MSP1) is a highly polymorphic Plasmodium falciparum merozoite surface protein implicated in the invasion of human erythrocytes during the asexual cycle. It forms a...

Functional Analysis of Plasmodium falciparum Apical Membrane Antigen 1 Utilizing Interspecies Domains

Healer, Julie, Triglia, Tony, Hodder, Anthony N., Gemmill, Alan W., Cowman, Alan F.

Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate whose function has not been unequivocally defined. Partial complementation of function can be achieved by...

Evidence for a Common Role for the Serine-Type Plasmodium falciparum Serine Repeat Antigen Proteases: Implications for Vaccine and Drug Design▿ †

McCoubrie, Joanne E., Miller, Susanne K., Sargeant, Tobias, Good, Robert T., Hodder, Anthony N., Speed, Terence P., ...

Serine repeat antigens (SERAs) are a family of secreted “cysteine-like” proteases of Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in place of the canonical...

Inhibition of Malaria Parasite Development by a Cyclic Peptide That Targets the Vital Parasite Protein SERA5▿

Fairlie, W. Douglas, Spurck, Tim P., McCoubrie, Joanne E., Gilson, Paul R., Miller, Susanne K., McFadden, Geoffrey I., ...

The serine repeat antigen (SERA) proteins of the malaria parasites Plasmodium spp. contain a putative enzyme domain similar to that of papain family cysteine proteases. In Plasmodium falciparum...

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

Hodder, Anthony N, Maier, Alexander G, Rug, Melanie, Brown, Monica, Hommel, Mirja, Pantic, Ivan, ...

Virulence of Plasmodium falciparum, the most lethal parasitic disease in humans, results in part from adhesiveness and increased rigidity of infected erythrocytes. Pf332 is trafficked to the...