Anthony W. I. Lo

A 330 kb CENP-A binding domain and altered replication timing at a human neocentromere

Lo, Anthony W.I., Craig, Jeffrey M., Saffery, Richard, Kalitsis, Paul, Irvine, Danielle V., Earle, Elizabeth, ...

Centromere protein A (CENP-A) is an essential centromere-specific histone H3 homologue. Using combined chromatin immunoprecipitation and DNA array analysis, we have defined a 330 kb CENP-A binding...

Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells

Lo, Anthony W. I., Sprung, Carl N., Fouladi, Bijan, Pedram, Mehrdad, Sabatier, Laure, Ricoul, Michelle, ...

Telomeres are essential for protecting the ends of chromosomes and preventing chromosome fusion. Telomere loss has been proposed to play an important role in the chromosomal rearrangements associated...

Centromeric chromatin pliability and memory at a human neocentromere

Craig, Jeffrey M., Wong, Lee H., Lo, Anthony W.I., Earle, Elizabeth, Choo, K.H.Andy

We show that Trichostatin A (TSA)-induced partial histone hyperacetylation causes a unidirectional shift in the position of a previously defined binding domain for the centromere-specific histone H3...

A Novel Chromatin Immunoprecipitation and Array (CIA) Analysis Identifies a 460-kb CENP-A-Binding Neocentromere DNA

Lo, Anthony W.I., Magliano, Dianna J., Sibson, Mandy C., Kalitsis, Paul, Craig, Jeffrey M., Choo, K.H. Andy

Centromere protein A (CENP-A) is an essential histone H3-related protein that constitutes the specialized chromatin of an active centromere. It has been suggested that this protein plays a key role...

Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse¶

Pedram, Mehrdad, Sprung, Carl N., Gao, Qing, Lo, Anthony W. I., Reynolds, Gloria E., Murnane, John P.

Reversible transcriptional silencing of genes located near telomeres, termed the telomere position effect (TPE), is well characterized in Saccharomyces cerevisiae. TPE has also been observed in human...

DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell Line

Lo, Anthony W I, Sabatier, Laure, Fouladi, Bijan, Pottier, Géraldine, Ricoul, Michelle, Murnane, John P

The development of genomic instability is an important step in generating the multiple genetic changes required for cancer. One consequence of genomic instability is the overexpression of oncogenes...

A 330 kb CENP-A binding domain and altered replication timing at a human neocentromere

Lo, Anthony W.I., Craig, Jeffrey M., Saffery, Richard, Kalitsis, Paul, Irvine, Danielle V., Earle, Elizabeth, ...

Centromere protein A (CENP-A) is an essential centromere-specific histone H3 homologue. Using combined chromatin immunoprecipitation and DNA array analysis, we have defined a 330 kb CENP-A binding...

Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells

Lo, Anthony W. I., Sprung, Carl N., Fouladi, Bijan, Pedram, Mehrdad, Sabatier, Laure, Ricoul, Michelle, ...

Telomeres are essential for protecting the ends of chromosomes and preventing chromosome fusion. Telomere loss has been proposed to play an important role in the chromosomal rearrangements associated...

Centromeric chromatin pliability and memory at a human neocentromere

Craig, Jeffrey M., Wong, Lee H., Lo, Anthony W.I., Earle, Elizabeth, Choo, K.H.Andy

We show that Trichostatin A (TSA)-induced partial histone hyperacetylation causes a unidirectional shift in the position of a previously defined binding domain for the centromere-specific histone H3...

A Novel Chromatin Immunoprecipitation and Array (CIA) Analysis Identifies a 460-kb CENP-A-Binding Neocentromere DNA

Lo, Anthony W.I., Magliano, Dianna J., Sibson, Mandy C., Kalitsis, Paul, Craig, Jeffrey M., Choo, K.H. Andy

Centromere protein A (CENP-A) is an essential histone H3-related protein that constitutes the specialized chromatin of an active centromere. It has been suggested that this protein plays a key role...

Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse¶

Pedram, Mehrdad, Sprung, Carl N., Gao, Qing, Lo, Anthony W. I., Reynolds, Gloria E., Murnane, John P.

Reversible transcriptional silencing of genes located near telomeres, termed the telomere position effect (TPE), is well characterized in Saccharomyces cerevisiae. TPE has also been observed in human...

DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell Line

Lo, Anthony W I, Sabatier, Laure, Fouladi, Bijan, Pottier, Géraldine, Ricoul, Michelle, Murnane, John P

The development of genomic instability is an important step in generating the multiple genetic changes required for cancer. One consequence of genomic instability is the overexpression of oncogenes...

A 21-Year-Old Pregnant Woman with Hypertension and Proteinuria

Luk, Andrea, Ma, Ronald C. W, Lam, Ching Wan, Tam, Wing Hung, Lo, Anthony W. I, Ng, Enders K. W, ...

Ronald Ma and colleagues describe the differential diagnosis, investigation, and management of a 21-year-old pregnant woman presenting with hypertension and proteinuria at 20 weeks of gestation.