López, Giovanni, Adaui, Vanessa, González, Elsa, Clark, Daniel, ...
The HTLV proviral load remains the best surrogate marker for disease progression. Real-time PCR techniques have been developed for detection and quantification of cosmopolitan HTLV-1a and HTLV-2. As...
Martin-Latil, Sandra, Gnädig, Nina, Mallet, Adeline, Prevost, Marie-Christine, Desdouits, Marion, Gessain, Antoine, ...
No abstract available.
Patin, Etienne, Laval, Guillaume, B. Barreiro, Luis, Salas, Antonio, Semino, Ornella, Santachiara-Benerecetti, Silvana, ...
The transition from hunting and gathering to farming involved a major cultural innovation that has spread rapidly over most of the globe in the last ten millennia. In sub-Saharan Africa,...
Patin, Etienne, Laval, Guillaume, B. Barreiro, Luis, Salas, Antonio, Semino, Ornella, Santachiara-Benerecetti, Silvana, ...
The transition from hunting and gathering to farming involved a major cultural innovation that has spread rapidly over most of the globe in the last ten millennia. In sub-Saharan Africa,...
No abstract available.
A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27 (2008)
Plancoulaine, Sabine, Gessain, Antoine, Tortevoye, Patricia, Boland-Auge, Anne, Vasilescu, Alexandre, Matsuda, Fumihito, ...
No abstract available.
Alteration of blood-brain barrier integrity by retroviral infection. (2008)
Afonso, Philippe V., Ozden, Simona, Cumont, Marie-Christine, Seilhean, Danielle, Cartier, Luis, Rezaie, Payam, ...
The blood-brain barrier (BBB), which forms the interface between the blood and the cerebral parenchyma, has been shown to be disrupted during retroviral-associated neuromyelopathies. Human T...
Alteration of blood-brain barrier integrity by retroviral infection. (2008)
Afonso, Philippe V., Ozden, Simona, Cumont, Marie-Christine, Seilhean, Danielle, Cartier, Luis, Rezaie, Payam, ...
The blood-brain barrier (BBB), which forms the interface between the blood and the cerebral parenchyma, has been shown to be disrupted during retroviral-associated neuromyelopathies. Human T...
Alteration of blood-brain barrier integrity by retroviral infection. (2008)
Afonso, Philippe V., Ozden, Simona, Cumont, Marie-Christine, Seilhean, Danielle, Cartier, Luis, Rezaie, Payam, ...
The blood-brain barrier (BBB), which forms the interface between the blood and the cerebral parenchyma, has been shown to be disrupted during retroviral-associated neuromyelopathies. Human T...
Characterization of Reemerging Chikungunya Virus (2007)
Marion Sourisseau, Clémentine Schilte, Nicoletta Casartelli, Céline Trouillet, Florence Guivel-Benhassine, Dominika Rudnicka, ...
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash,...
Tortevoye, Patricia, Moutel, Grégoire, Tuppin, Philippe, Plancoulaine, Sabine, Joubert, Michel, Hervé, Christian, ...
BACKGROUND: This paper discusses the ethical aspects of a large research program in virology, conducted since 1994 and which has evolved in parallel with the elaboration of bioethics laws in France....
Tortevoye, Patricia, Moutel, Grégoire, Tuppin, Philippe, Plancoulaine, Sabine, Joubert, Michel, Hervé, Christian, ...
BACKGROUND: This paper discusses the ethical aspects of a large research program in virology, conducted since 1994 and which has evolved in parallel with the elaboration of bioethics laws in France....
Human muscle satellite cells as targets of Chikungunya virus infection. (2007)
Ozden, Simona, Huerre, Michel, Riviere, Jean-Pierre, Coffey, Lark L, Afonso, Philippe V, Mouly, Vincent, ...
BACKGROUND: Chikungunya (CHIK) virus is a mosquito-transmitted alphavirus that causes in humans an acute infection characterised by fever, polyarthralgia, head-ache, and myalgia. Since 2005, the...
Human muscle satellite cells as targets of Chikungunya virus infection. (2007)
Ozden, Simona, Huerre, Michel, Riviere, Jean-Pierre, Coffey, Lark L, Afonso, Philippe V, Mouly, Vincent, ...
BACKGROUND: Chikungunya (CHIK) virus is a mosquito-transmitted alphavirus that causes in humans an acute infection characterised by fever, polyarthralgia, head-ache, and myalgia. Since 2005, the...
Tortevoye, Patricia, Moutel, Grégoire, Tuppin, Philippe, Plancoulaine, Sabine, Joubert, Michel, Hervé, Christian, ...
BACKGROUND: This paper discusses the ethical aspects of a large research program in virology, conducted since 1994 and which has evolved in parallel with the elaboration of bioethics laws in France....
Characterization of reemerging chikungunya virus. (2007)
Sourisseau, Marion, Schilte, Clémentine, Casartelli, Nicoletta, Trouillet, Céline, Guivel-Benhassine, Florence, Rudnicka, Dominika, ...
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash,...
Characterization of reemerging chikungunya virus. (2007)
Sourisseau, Marion, Schilte, Clémentine, Casartelli, Nicoletta, Trouillet, Céline, Guivel-Benhassine, Florence, Rudnicka, Dominika, ...
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash,...
Characterization of reemerging chikungunya virus. (2007)
Sourisseau, Marion, Schilte, Clémentine, Casartelli, Nicoletta, Trouillet, Céline, Guivel-Benhassine, Florence, Rudnicka, Dominika, ...
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash,...
Kim, Felix J, Lavanya, Madakasira, Gessain, Antoine, Gallego, Sandra, Battini, Jean-Luc, Sitbon, Marc, ...
Abstract Four primate (PTLV), human (HTLV) and simian (STLV) T-cell leukemia virus types, have been characterized thus far, with evidence of a simian zoonotic origin for HTLV-1, HTLV-2 and HTLV-3 in...
Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeanacolony (2006)
Calattini, Sara, Wanert, Fanélie, Thierry, Bernard, Schmitt, Christine, Bassot, Sylviane, Saib, Ali, ...
Abstract Background Foamy viruses are exogenous complex retroviruses that are highly endemic in several animal species, including monkeys and apes, where they cause persistent infection. Simian foamy...
A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27 (2006)
Plancoulaine, Sabine, Gessain, Antoine, Tortevoye, Patricia, Boland-Auge, Anne, Vasilescu, Alexandre, Matsuda, Fumihiko, ...
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is a human oncoretrovirus causing adult T-cell leukemia/lymphoma and chronic neuromyelopathy. We previously showed by segregation analysis that a...
Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles (2006)
Verdu, Paul, Barreiro, Luis B., Patin, Etienne, Gessain, Antoine, Cassar, Olivier, Kidd, Judith R., ...
Human mannose-binding lectin (MBL) is a member of the collectin protein family that binds a broad range of microorganisms and activates the lectin-complement pathway of innate immunity. Common...
Evolutionary Insights into the High Worldwide Prevalence of MBL2 Deficiency Alleles (2006)
Verdu, Paul, Barreiro, Luis B., Patin, Etienne, Gessain, Antoine, Cassar, Olivier, Kidd, Judith R., ...
Human mannose-binding lectin (MBL) is a member of the collectin protein family that binds a broad range of microorganisms and activates the lectin-complement pathway of innate immunity. Common...
A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27 (2006)
Plancoulaine, Sabine, Gessain, Antoine, Tortevoye, Patricia, Boland-Auge, Anne, Vasilescu, Alexandre, Matsuda, Fumihiko, ...
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is a human oncoretrovirus causing adult T-cell leukemia/lymphoma and chronic neuromyelopathy. We previously showed by segregation analysis that a...
Presence of a functional but dispensable Nuclear Export Signal in the HTLV-2 Tax protein (2005)
Chevalier, Sébastien A, Meertens, Laurent, Calattini, Sara, Gessain, Antoine, Kiemer, Lars, Mahieux, Renaud
Abstract Background Human T-cell leukemia virus type 1 and type 2 are related human retroviruses. HTLV-1 is the etiological agent of the Adult T-cell Leukemia/Lymphoma and of the Tropical Spastic...
Meertens, Laurent, Gessain, Antoine
Full-genome sequencing and analysis of the highly divergent simian T-cell lymphotropic virus type 1 (STLV-1) strain MarB43 in Macaca arctoides indicated that its open reading frame structure is...
Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa (2005)
Calattini, Sara, Chevalier, Sébastien, Duprez, Renan, Bassot, Sylviane, Froment, Alain, Mahieux, Renaud, ...
Abstract Human T-cell Leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have...
Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa. (2005)
Calattini, Sara, Alain Chevalier, Sébastien, Duprez, Renan, Bassot, Sylviane, Froment, Alain, Mahieux, Renaud, ...
Human T-cell Leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have simian...
Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa. (2005)
Calattini, Sara, Alain Chevalier, Sébastien, Duprez, Renan, Bassot, Sylviane, Froment, Alain, Mahieux, Renaud, ...
Human T-cell Leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have simian...
Kazanji,Mirdad, Gessain,Antoine
We review here the epidemiological studies performed by our group on human retrovirus HTLV-I and HTLV-II infections and the associated diseases in French Guiana since 1984. French Guiana is an...
High Titers of Anti-Human Herpesvirus 8 Antibodies in Elderly Males in an Endemic Population (2002)
Plancoulaine, Sabine, Abel, Laurent, Van Beveren, Monique, Gessain, Antoine
Human herpesvirus 8 (HHV8) is the etiologic agent of Kaposi's sarcoma (KS), a tumor occurring mainly among elderly men in its endemic and classical forms. The male-to-female ratio of KS in different...
Mortreux, Franck, Leclercq, India, Gabet, Anne-Sophie, Leroy, Arnaud, Westhof, Eric, Gessain, Antoine, ...
Background: Human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia/lymphoma, shows intrapatient genetic variability. Although HTLV-1 can replicate via the reverse...
A Novel gamma 2-Herpesvirus of the Rhadinovirus 2 Lineage in Chimpanzees (2001)
Lacoste, Vincent, Mauclère, Philippe, Dubreuil, Guy, Lewis, John, Georges-Courbot, Marie-Claude, Gessain, Antoine
Mahieux, Renaud, Horal, Peter, Mauclère, Philippe, Mercereau-Puijalon, Odile, Guillotte, Micheline, Meertens, Laurent, ...
To gain insight on the significance of human T-cell lymphotropic virus type 1 (HTLV-1) indeterminate serological reactivities, we studied villagers of South Cameroon, focusing on a frequent and...
Rouet, François, Meertens, Laurent, Courouble, Géry, Herrmann-Storck, Cécile, Pabingui, Raymond, Chancerel, Bruno, ...
To investigate the significance of serological human T-cell lymphotropic virus type 1 (HLTV-1) Gag indeterminate Western blot (WB) patterns in the Caribbean, a 6-year (1993 to 1998) cross-sectional...
Nicot, Christophe, Mahieux, Renaud, Pise-Masison, Cynthia, Brady, John, Gessain, Antoine, Yamaoka, Shoji, ...
The proto-oncogene c-myb is essential for a controlled balance between cell growth and differentiation. Aberrant c-Myb activity has been reported for numerous human cancers, and enforced c-Myb...
Mahieux, Renaud, Chappey, Colombe, Georges-Courbot, Marie-Claude, Dubreuil, Guy, Mauclere, Philippe, Georges, Alain, ...
A recent serological and molecular survey of a semifree-ranging colony of mandrills (Mandrillus sphinx) living in Gabon, central Africa, indicated that 6 of 102 animals, all males, were infected with...
Host Sequences Flanking the Human T-Cell Leukemia Virus Type 1 Provirus In Vivo
Leclercq, India, Mortreux, Franck, Cavrois, Marielle, Leroy, Arnaud, Gessain, Antoine, Wain-Hobson, Simon, ...
Human pathogenic retroviruses do not have common loci of integration. However, many factors, such as chromatin structure, transcriptional activity, DNA-protein interaction, CpG methylation, and...
Kazanji, Mirdad, Ureta-Vidal, Abel, Ozden, Simona, Tangy, Frédéric, De Thoisy, Benoit, Fiette, Laurence, ...
The aim of this study was to investigate the distribution of human T-cell leukemia virus type 1 (HTLV-1) in various organs of serially sacrificed squirrel monkeys (Saimiri sciureus) in order to...
Mahieux, Renaud, Pise-Masison, Cynthia A., Lambert, Paul F., Nicot, Christophe, De Marchis, Laura, Gessain, Antoine, ...
We have analyzed the functional activity of the p53 tumor suppressor in human T-cell lymphotropic virus type 2 (HTLV-2)-transformed cells. Abundant levels of the p53 protein were detected in both...
Simian Homologues of Human Gamma-2 and Betaherpesviruses in Mandrill and Drill Monkeys
Lacoste, Vincent, Mauclere, Philippe, Dubreuil, Guy, Lewis, John, Georges-Courbot, Marie-Claude, Rigoulet, Jacques, ...
Recent serological and molecular surveys of different primate species allowed the characterization of several Kaposi's sarcoma-associated herpesvirus (KSHV) homologues in macaques, African green...
Kazanji, Mirdad, Tartaglia, James, Franchini, Genoveffa, De Thoisy, Benoit, Talarmin, Antoine, Contamin, Hugues, ...
We assessed the immunogenicities and efficacies of two highly attenuated vaccinia virus-derived NYVAC vaccine candidates encoding the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) env gene or...
Meertens, Laurent, Mahieux, Renaud, Mauclère, Philippe, Lewis, John, Gessain, Antoine
Among 65 samples obtained from a primate rescue center located in Cameroon, two female adult red-capped mangabeys (Cercocebus torquatus) (CTO-602 and CTO-604), of wild-caught origin, had a peculiar...
Meertens, Laurent, Gessain, Antoine
Among eight samples obtained from a French primatology research center, six adult guinea baboons (Papio hamadryas papio), caught in the wild in Senegal, had a peculiar human T-cell leukemia virus...
De Thoisy, Benoit, Pouliquen, Jean-François, Lacoste, Vincent, Gessain, Antoine, Kazanji, Mirdad
The recent finding of a novel Epstein-Barr virus-related lymphocryptovirus (CalHV-3) in a captive colony of common marmoset (Callithrix jacchus) in the United States modifies the view that the host...
A Novel γ2-Herpesvirus of the Rhadinovirus 2 Lineage in Chimpanzees
Lacoste, Vincent, Mauclère, Philippe, Dubreuil, Guy, Lewis, John, Georges-Courbot, Marie-Claude, Gessain, Antoine
Old World monkeys and, recently, African great apes have been shown, by serology and polymerase chain reaction (PCR), to harbor different γ2-herpesviruses closely related to Kaposi's...
Ozden, Simona, Cochet, Madeleine, Mikol, Jacqueline, Teixeira, Antonio, Gessain, Antoine, Pique, Claudine
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) infection can lead to the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), concomitantly with or without other...
Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa
Calattini, Sara, Chevalier, Sébastien Alain, Duprez, Renan, Bassot, Sylviane, Froment, Alain, Mahieux, Renaud, ...
Human T-cell Leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have simian...
Duprez, Renan, Kassa-Kelembho, Eric, Plancoulaine, Sabine, Brière, Josette, Fossi, Mireille, Kobangue, Léon, ...
Epidemic Kaposi's sarcoma (KS) is one of the most frequent types of cancer in several African countries; however, very few data are available on human herpesvirus 8 (HHV-8) markers in KS patients...
Presence of a functional but dispensable Nuclear Export Signal in the HTLV-2 Tax protein
Chevalier, Sébastien A, Meertens, Laurent, Calattini, Sara, Gessain, Antoine, Kiemer, Lars, Mahieux, Renaud
Restriction of Foamy Viruses by APOBEC Cytidine Deaminases†
Delebecque, Frédéric, Suspène, Rodolphe, Calattini, Sara, Casartelli, Nicoletta, Saïb, Ali, Froment, Alain, ...
Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic...
Sibon, David, Gabet, Anne-Sophie, Zandecki, Marc, Pinatel, Christiane, Thête, Julien, Delfau-Larue, Marie-Hélène, ...
Human T cell leukemia virus type 1 (HTLV-1) infects both CD4+ and CD8+ lymphocytes, yet it induces adult T cell leukemia/lymphoma (ATLL) that is regularly of the CD4+ phenotype. Here we show that in...
Kim, Felix J, Lavanya, Madakasira, Gessain, Antoine, Gallego, Sandra, Battini, Jean-Luc, Sitbon, Marc, ...
Four primate (PTLV), human (HTLV) and simian (STLV) T-cell leukemia virus types, have been characterized thus far, with evidence of a simian zoonotic origin for HTLV-1, HTLV-2 and HTLV-3 in Africa....
Diop, Saliou, Calattini, Sara, Abah-Dakou, Julienne, Thiam, Doudou, Diakhaté, Lamine, Gessain, Antoine
In 2002, human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 seroprevalence was 0.16% (8/4,900) in blood donors from Dakar, Senegal. Most of the positive donors originated from the country’s...
Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony
Calattini, Sara, Wanert, Fanélie, Thierry, Bernard, Schmitt, Christine, Bassot, Sylviane, Saib, Ali, ...
DC-SIGN Facilitates Fusion of Dendritic Cells with Human T-Cell Leukemia Virus Type 1-Infected Cells
Ceccaldi, Pierre-Emmanuel, Delebecque, Frédéric, Prevost, Marie-Christine, Moris, Arnaud, Abastado, Jean-Pierre, Gessain, Antoine, ...
Interactions between the oncogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) and dendritic cells (DCs) are poorly characterized. We show here that monocyte-derived DCs form syncytia and...
Mahieux, Renaud, Horal, Peter, Mauclère, Philippe, Mercereau-Puijalon, Odile, Guillotte, Micheline, Meertens, Laurent, ...
To gain insight on the significance of human T-cell lymphotropic virus type 1 (HTLV-1) indeterminate serological reactivities, we studied villagers of South Cameroon, focusing on a frequent and...
Rouet, François, Meertens, Laurent, Courouble, Géry, Herrmann-Storck, Cécile, Pabingui, Raymond, Chancerel, Bruno, ...
To investigate the significance of serological human T-cell lymphotropic virus type 1 (HLTV-1) Gag indeterminate Western blot (WB) patterns in the Caribbean, a 6-year (1993 to 1998) cross-sectional...
Nicot, Christophe, Mahieux, Renaud, Pise-Masison, Cynthia, Brady, John, Gessain, Antoine, Yamaoka, Shoji, ...
The proto-oncogene c-myb is essential for a controlled balance between cell growth and differentiation. Aberrant c-Myb activity has been reported for numerous human cancers, and enforced c-Myb...
Mahieux, Renaud, Chappey, Colombe, Georges-Courbot, Marie-Claude, Dubreuil, Guy, Mauclere, Philippe, Georges, Alain, ...
A recent serological and molecular survey of a semifree-ranging colony of mandrills (Mandrillus sphinx) living in Gabon, central Africa, indicated that 6 of 102 animals, all males, were infected with...
Host Sequences Flanking the Human T-Cell Leukemia Virus Type 1 Provirus In Vivo
Leclercq, India, Mortreux, Franck, Cavrois, Marielle, Leroy, Arnaud, Gessain, Antoine, Wain-Hobson, Simon, ...
Human pathogenic retroviruses do not have common loci of integration. However, many factors, such as chromatin structure, transcriptional activity, DNA-protein interaction, CpG methylation, and...
Kazanji, Mirdad, Ureta-Vidal, Abel, Ozden, Simona, Tangy, Frédéric, De Thoisy, Benoit, Fiette, Laurence, ...
The aim of this study was to investigate the distribution of human T-cell leukemia virus type 1 (HTLV-1) in various organs of serially sacrificed squirrel monkeys (Saimiri sciureus) in order to...
Mahieux, Renaud, Pise-Masison, Cynthia A., Lambert, Paul F., Nicot, Christophe, De Marchis, Laura, Gessain, Antoine, ...
We have analyzed the functional activity of the p53 tumor suppressor in human T-cell lymphotropic virus type 2 (HTLV-2)-transformed cells. Abundant levels of the p53 protein were detected in both...
Simian Homologues of Human Gamma-2 and Betaherpesviruses in Mandrill and Drill Monkeys
Lacoste, Vincent, Mauclere, Philippe, Dubreuil, Guy, Lewis, John, Georges-Courbot, Marie-Claude, Rigoulet, Jacques, ...
Recent serological and molecular surveys of different primate species allowed the characterization of several Kaposi's sarcoma-associated herpesvirus (KSHV) homologues in macaques, African green...
Kazanji, Mirdad, Tartaglia, James, Franchini, Genoveffa, De Thoisy, Benoit, Talarmin, Antoine, Contamin, Hugues, ...
We assessed the immunogenicities and efficacies of two highly attenuated vaccinia virus-derived NYVAC vaccine candidates encoding the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) env gene or...
Meertens, Laurent, Mahieux, Renaud, Mauclère, Philippe, Lewis, John, Gessain, Antoine
Among 65 samples obtained from a primate rescue center located in Cameroon, two female adult red-capped mangabeys (Cercocebus torquatus) (CTO-602 and CTO-604), of wild-caught origin, had a peculiar...
Meertens, Laurent, Gessain, Antoine
Among eight samples obtained from a French primatology research center, six adult guinea baboons (Papio hamadryas papio), caught in the wild in Senegal, had a peculiar human T-cell leukemia virus...
De Thoisy, Benoit, Pouliquen, Jean-François, Lacoste, Vincent, Gessain, Antoine, Kazanji, Mirdad
The recent finding of a novel Epstein-Barr virus-related lymphocryptovirus (CalHV-3) in a captive colony of common marmoset (Callithrix jacchus) in the United States modifies the view that the host...
A Novel γ2-Herpesvirus of the Rhadinovirus 2 Lineage in Chimpanzees
Lacoste, Vincent, Mauclère, Philippe, Dubreuil, Guy, Lewis, John, Georges-Courbot, Marie-Claude, Gessain, Antoine
Old World monkeys and, recently, African great apes have been shown, by serology and polymerase chain reaction (PCR), to harbor different γ2-herpesviruses closely related to Kaposi's...
Ozden, Simona, Cochet, Madeleine, Mikol, Jacqueline, Teixeira, Antonio, Gessain, Antoine, Pique, Claudine
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) infection can lead to the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), concomitantly with or without other...
Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa
Calattini, Sara, Chevalier, Sébastien Alain, Duprez, Renan, Bassot, Sylviane, Froment, Alain, Mahieux, Renaud, ...
Human T-cell Leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have simian...
Duprez, Renan, Kassa-Kelembho, Eric, Plancoulaine, Sabine, Brière, Josette, Fossi, Mireille, Kobangue, Léon, ...
Epidemic Kaposi's sarcoma (KS) is one of the most frequent types of cancer in several African countries; however, very few data are available on human herpesvirus 8 (HHV-8) markers in KS patients...
Presence of a functional but dispensable Nuclear Export Signal in the HTLV-2 Tax protein
Chevalier, Sébastien A, Meertens, Laurent, Calattini, Sara, Gessain, Antoine, Kiemer, Lars, Mahieux, Renaud
Restriction of Foamy Viruses by APOBEC Cytidine Deaminases†
Delebecque, Frédéric, Suspène, Rodolphe, Calattini, Sara, Casartelli, Nicoletta, Saïb, Ali, Froment, Alain, ...
Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic...
Sibon, David, Gabet, Anne-Sophie, Zandecki, Marc, Pinatel, Christiane, Thête, Julien, Delfau-Larue, Marie-Hélène, ...
Human T cell leukemia virus type 1 (HTLV-1) infects both CD4+ and CD8+ lymphocytes, yet it induces adult T cell leukemia/lymphoma (ATLL) that is regularly of the CD4+ phenotype. Here we show that in...
Diop, Saliou, Calattini, Sara, Abah-Dakou, Julienne, Thiam, Doudou, Diakhaté, Lamine, Gessain, Antoine
In 2002, human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 seroprevalence was 0.16% (8/4,900) in blood donors from Dakar, Senegal. Most of the positive donors originated from the country’s...
DC-SIGN Facilitates Fusion of Dendritic Cells with Human T-Cell Leukemia Virus Type 1-Infected Cells
Ceccaldi, Pierre-Emmanuel, Delebecque, Frédéric, Prevost, Marie-Christine, Moris, Arnaud, Abastado, Jean-Pierre, Gessain, Antoine, ...
Interactions between the oncogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) and dendritic cells (DCs) are poorly characterized. We show here that monocyte-derived DCs form syncytia and...
Kim, Felix J, Lavanya, Madakasira, Gessain, Antoine, Gallego, Sandra, Battini, Jean-Luc, Sitbon, Marc, ...
Four primate (PTLV), human (HTLV) and simian (STLV) T-cell leukemia virus types, have been characterized thus far, with evidence of a simian zoonotic origin for HTLV-1, HTLV-2 and HTLV-3 in Africa....
Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony
Calattini, Sara, Wanert, Fanélie, Thierry, Bernard, Schmitt, Christine, Bassot, Sylviane, Saib, Ali, ...
Calattini, Sara, Chevalier, Sébastien Alain, Duprez, Renan, Afonso, Philippe, Froment, Alain, Gessain, Antoine, ...
We and others have recently uncovered the existence of human T-cell lymphotropic virus type 3 (HTLV-3), the third member of the HTLV family. We have now sequenced the full-length HTLV-3Pyl43...
Muscle Wasting Induced by HTLV-1 Tax-1 Protein : An in Vitro and in Vivo Study
Ozden, Simona, Mouly, Vincent, Prevost, Marie-Christine, Gessain, Antoine, Butler-Browne, Gillian, Ceccaldi, Pierre-Emmanuel
Besides tropical spastic paraparesis/human T-cell leukemia virus type-1 (HTLV-1)-associated myelopathy, the human retrovirus HTLV-1 causes inflammatory disorders such as myositis. Although the...
Human Muscle Satellite Cells as Targets of Chikungunya Virus Infection
Ozden, Simona, Huerre, Michel, Riviere, Jean-Pierre, Coffey, Lark L., Afonso, Philippe V., Mouly, Vincent, ...
Characterization of Reemerging Chikungunya Virus
Sourisseau, Marion, Schilte, Clémentine, Casartelli, Nicoletta, Trouillet, Céline, Guivel-Benhassine, Florence, Rudnicka, Dominika, ...
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash,...
Chevalier, Sébastien Alain, Walic, Marine, Calattini, Sara, Mallet, Adeline, Prévost, Marie-Christine, Gessain, Antoine, ...
Together with their simian T-cell lymphotropic virus (STLV) equivalent, human T-cell lymphotropic virus type 1 (HTLV-1), HTLV-2, and HTLV-3 form the primate T-cell lymphotropic virus (PTLV) group....
Pique, Claudine, Ureta-Vidal, Abel, Gessain, Antoine, Chancerel, Bruno, Gout, Olivier, Tamouza, Riad, ...
Human T cell leukemia virus type I (HTLV-I) is a persistent virus that causes adult T cell leukemia and tropical spastic paraparesis/HTLV-I–associated myelopathy. Studies on rabbits have shown that...
Quintana-Murci, Lluís, Quach, Hélène, Harmant, Christine, Luca, Francesca, Massonnet, Blandine, Patin, Etienne, ...
Two groups of populations with completely different lifestyles—the Pygmy hunter–gatherers and the Bantu-speaking farmers—coexist in Central Africa. We investigated the origins of these two...
Chevalier, Sébastien Alain, Ko, Nga Ling, Calattini, Sara, Mallet, Adeline, Prévost, Marie-Christine, Kehn, Kylene, ...
We and others have uncovered the existence of human T-cell lymphotropic virus type 3 (HTLV-3). We have now generated an HTLV-3 proviral clone. We established that gag, env, pol, pro, and tax/rex as...
Alteration of Blood–Brain Barrier Integrity by Retroviral Infection
Afonso, Philippe V., Ozden, Simona, Cumont, Marie-Christine, Seilhean, Danielle, Cartier, Luis, Rezaie, Payam, ...
The blood–brain barrier (BBB), which forms the interface between the blood and the cerebral parenchyma, has been shown to be disrupted during retroviral-associated neuromyelopathies. Human T...
Patin, Etienne, Laval, Guillaume, Barreiro, Luis B., Salas, Antonio, Semino, Ornella, Santachiara-Benerecetti, Silvana, ...
The transition from hunting and gathering to farming involved a major cultural innovation that has spread rapidly over most of the globe in the last ten millennia. In sub-Saharan Africa,...
Etenna, Sonia Lekana-Douki, Caron, Mélanie, Besson, Guillaume, Makuwa, Maria, Gessain, Antoine, Mahé, Antoine, ...
Human T-cell leukemia virus type 1 (HTLV-1) is highly endemic in areas of central Africa; mother-to-child transmission and sexual transmission are considered to be the predominant routes. To...
Jones, Kathryn S., Huang, Ying K., Chevalier, Sébastien A., Afonso, Philippe V., Petrow-Sadowski, Cari, Bertolette, Daniel C., ...
Little is known about the transmission or tropism of the newly discovered human retrovirus, human T-cell lymphotropic virus type 3 (HTLV-3). Here, we examine the entry requirements of HTLV-3 using...