Pathogenomics: An updated European Research Agenda (2008)
Demuth, Andreas, Aharonowitz, Yair, Bachmann, Till T., Blum-Oehler, Gabriele, Buchrieser, Carmen, Covacci, Antonello, ...
Duccio Medini, Antonello Covacci, Claudio Donati
From the analysis of 251 prokaryotic genomes stored in public databases, the 761,260 deduced proteins were used to reconstruct a complete set of bacterial proteic families. Using the new Overlap...
Stein, Markus, Rappuoli, Rino, Covacci, Antonello
Helicobacter pylori strains associated with severe tissue damage and inflammation possess a unique genetic locus, cag, containing 31 genes originating from a distant event of horizontal transfer and...
Censini, Stefano, Lange, Christina, Xiang, Zhaoying, Crabtree, Jean E., Ghiara, Paolo, Borodovsky, Mark, ...
cagA, a gene that codes for an immunodominant antigen, is present only in Helicobacter pylori strains that are associated with severe forms of gastroduodenal disease (type I strains). We found that...
D'Abusco, Anna Scotto, Del Grosso, Maria, Censini, Stefano, Covacci, Antonello, Pantosti, Annalisa
Enterotoxigenic Bacteroides fragilis (ETBF) strains are associated with diarrheal disease in children. These strains produce a zinc metalloprotease enterotoxin, or fragilysin, that can be detected by...
Occhialini, Alessandra, Marais, Armelle, Urdaci, Maria, Sierra, Rafaela, Muñoz, Nubia, Covacci, Antonello, ...
The composition and in vitro expression of the cag pathogenicity island genes in a group of Helicobacter pylori strains obtained from patients suffering from chronic gastritis-associated dyspepsia (n...
Glocker, Erik, Lange, Christina, Covacci, Antonello, Bereswill, Stefan, Kist, Manfred, Pahl, Heike L.
Helicobacter pylori is the etiological agent in the development of chronic gastritis, duodenal ulceration, and gastric adenocarcinoma. The difference in virulence between individual strains is...
Joyce, Elizabeth A., Kawale, Amita, Censini, Stefano, Kim, Charles C., Covacci, Antonello, Falkow, Stanley
Streptococcus pneumoniae causes several diseases, including otitis media, pneumonia, and meningitis. Although little is known about the regulation of or how individual pneumococcal factors contribute...
Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells
Bagnoli, Fabio, Buti, Ludovico, Tompkins, Lucy, Covacci, Antonello, Amieva, Manuel R.
CagA is a bacterial effector protein of Helicobacter pylori that is translocated via a type IV secretion system into gastric epithelial cells. We previously described that H. pylori require CagA to...
Stein, Markus, Rappuoli, Rino, Covacci, Antonello
Helicobacter pylori strains associated with severe tissue damage and inflammation possess a unique genetic locus, cag, containing 31 genes originating from a distant event of horizontal transfer and...
Censini, Stefano, Lange, Christina, Xiang, Zhaoying, Crabtree, Jean E., Ghiara, Paolo, Borodovsky, Mark, ...
cagA, a gene that codes for an immunodominant antigen, is present only in Helicobacter pylori strains that are associated with severe forms of gastroduodenal disease (type I strains). We found that...
D'Abusco, Anna Scotto, Del Grosso, Maria, Censini, Stefano, Covacci, Antonello, Pantosti, Annalisa
Enterotoxigenic Bacteroides fragilis (ETBF) strains are associated with diarrheal disease in children. These strains produce a zinc metalloprotease enterotoxin, or fragilysin, that can be detected by...
Occhialini, Alessandra, Marais, Armelle, Urdaci, Maria, Sierra, Rafaela, Muñoz, Nubia, Covacci, Antonello, ...
The composition and in vitro expression of the cag pathogenicity island genes in a group of Helicobacter pylori strains obtained from patients suffering from chronic gastritis-associated dyspepsia (n...
Glocker, Erik, Lange, Christina, Covacci, Antonello, Bereswill, Stefan, Kist, Manfred, Pahl, Heike L.
Helicobacter pylori is the etiological agent in the development of chronic gastritis, duodenal ulceration, and gastric adenocarcinoma. The difference in virulence between individual strains is...
Joyce, Elizabeth A., Kawale, Amita, Censini, Stefano, Kim, Charles C., Covacci, Antonello, Falkow, Stanley
Streptococcus pneumoniae causes several diseases, including otitis media, pneumonia, and meningitis. Although little is known about the regulation of or how individual pneumococcal factors contribute...
Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells
Bagnoli, Fabio, Buti, Ludovico, Tompkins, Lucy, Covacci, Antonello, Amieva, Manuel R.
CagA is a bacterial effector protein of Helicobacter pylori that is translocated via a type IV secretion system into gastric epithelial cells. We previously described that H. pylori require CagA to...
Medini, Duccio, Covacci, Antonello, Donati, Claudio
From the analysis of 251 prokaryotic genomes stored in public databases, the 761,260 deduced proteins were used to reconstruct a complete set of bacterial proteic families. Using the new Overlap...
Streptococcus pneumoniae Pilus Subunits Protect Mice against Lethal Challenge▿
Gianfaldoni, Claudia, Censini, Stefano, Hilleringmann, Markus, Moschioni, Monica, Facciotti, Claudia, Pansegrau, Werner, ...
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of...
Dotta, Francesco, Censini, Stefano, Marselli, Lorella, Masini, Matilde, Dionisi, Sabrina, ...
Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic β cells. Several studies have suggested an association between Coxsackie enterovirus seroconversion and onset...
Pneumococcal Pili Are Composed of Protofilaments Exposing Adhesive Clusters of Rrg A
Hilleringmann, Markus, Giusti, Fabiola, Baudner, Barbara C., Masignani, Vega, Covacci, Antonello, Rappuoli, Rino, ...
Pili have been identified on the cell surface of Streptococcus pneumoniae, a major cause of morbidity and mortality worldwide. In contrast to Gram-negative bacteria, little is known about the...
Pilus Operon Evolution in Streptococcus pneumoniae Is Driven by Positive Selection and Recombination
Muzzi, Alessandro, Moschioni, Monica, Covacci, Antonello, Rappuoli, Rino, Donati, Claudio
Bagnoli, Fabio, Moschioni, Monica, Donati, Claudio, Dimitrovska, Valentina, Ferlenghi, Ilaria, Facciotti, Claudia, ...
Analysis of publicly available genomes of Streptococcus pneumoniae has led to the identification of a new genomic element containing genes typical of gram-positive pilus islets (PIs). Here, we...
The Complete Genome Sequence of Helicobacter pylori Strain G27▿
Baltrus, David A., Amieva, Manuel R., Covacci, Antonello, Lowe, Todd M., Merrell, D. Scott, Ottemann, Karen M., ...
Helicobacter pylori is a gram-negative pathogen that colonizes the stomachs of over half the world's population and causes a spectrum of gastric diseases including gastritis, ulcers, and gastric...