Antonio A. Freitas

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. (2006)

Hao, Yi, Legrand, Nicolas, Freitas, Antonio A

Positive selection in the thymus and peripheral T cell survival depend on T cell receptor (TCR)-major histocompatibility complex (MHC) interactions, but it is not yet clear if both events follow...

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. (2006)

Almeida, Afonso R M, Zaragoza, Bruno, Freitas, Antonio A

Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25- cells, a phenomenon termed conversion. We evaluated the relative contribution of this...

Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation. (2006)

De La Coste, Alix, Freitas, Antonio A

Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These...

Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation. (2006)

De La Coste, Alix, Freitas, Antonio A

Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These...

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. (2006)

Almeida, Afonso R M, Zaragoza, Bruno, Freitas, Antonio A

Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25- cells, a phenomenon termed conversion. We evaluated the relative contribution of this...

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. (2006)

Hao, Yi, Legrand, Nicolas, Freitas, Antonio A

Positive selection in the thymus and peripheral T cell survival depend on T cell receptor (TCR)-major histocompatibility complex (MHC) interactions, but it is not yet clear if both events follow...

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells (2006)

Almeida, Afonso R. M., Zaragoza, Bruno, Freitas, Antonio A.

Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25- cells, a phenomenon termed conversion. We evaluated the relative contribution of this...

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells (2006)

Almeida, Afonso R. M., Zaragoza, Bruno, Freitas, Antonio A.

Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25− cells, a phenomenon termed conversion. We evaluated the relative contribution of this...

Endogenous VH gene family expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires (1991)

Grandien, Alf, Coutinho, Antonio, Andersson, Jan, Freitas, Antonio A.

VH gene family expression in single cells of the emergent, available and actual B cell repertoires of C57BL/6 mice was compared to that of two immunoglobulln (lg)-transgenic B6 lines (B6-Sp6 and...

Selection of VH gene repertoires: differentiating B cells of adult bone marrow mimic fetal development (1990)

Freitas, Antonio A., Andrade, Luiz, Lembezat, Marie-Pierre, Coutinho, Antonio, Honjo, T.

In the present study we have compared by in situ hybridization and by a CFU-B colony assay VH family usage in the pre-B and B cell compartments of the bone marrow of adult BALB/c and C57BL/6...

Population kinetics of peritoneal LPS-reactive B lymphocytes (1990)

Thomas-Vaslin, Véronique, Freitas, Antonio A., Nishikawa, S.

The dynamic behaviour of isolated populations of peritoneal LPS-reactive (LPSr) B lymphocytes was studied upon transfer of peritoneal cells (PerC) from C57BL/6 LPS responder into C57BL/10ScCr...

Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment (1989)

Thomas-Vaslin, Véronique, Freitas, Antonio A., Martinez-A, C

We have investigated the kinetic behaviour of LPS reactive B cells during the development of the immune system. By studying the persistence of LPS reactive spleen cells transferred from adult...

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity

Hao, Yi, Legrand, Nicolas, Freitas, Antonio A.

Positive selection in the thymus and peripheral T cell survival depend on T cell receptor (TCR)–major histocompatibility complex (MHC) interactions, but it is not yet clear if both events follow...