Type I IFN sets the stringency of B cell repertoire selection in the bone marrow (1999)
Vasconcellos, Rita, Braun, Deborah, Coutinho, Antonio, Demengeot, Jocelyne
Locally produced type I interferon (IFN-I) enhances the sensitivity of bone marrow B cell to IgM receptor ligation. The establishment of B cell repertoires, on the other hand, seems to involve...
B-lineage cell deficits in bone marrow of lpr/lpr mice (1996)
Sundblad, Anne, Coutinho, Antonio
Analyses of bone marrow (BM) lymphocytes in C57BL/6 mice homozygous for the lpr mutation (BS.Ipr) disclosed low numbers of pre-B and B cells, as compared with age-matched control B6 mice. BM...
Ronda, Nicoletta, Haury, Mattias, Nobrega, Alberto, Kaveri, Srinivas V., Coutinho, Antonio, Kazatchkine, Michel D.
The present study demonstrates that natural IgG with anti-endothelial cell activity is present in the serum of healthy individuals and in pooled normal human Ig. By using a novel method that allows...
Skewed V{beta} TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection (1994)
Coutinho, Antonio, Hontebeyrle-Joskowicz, Mirellle, Minoprio, Paola, Eisen, Harvey, Bandeira, Antonio
We have followed CD4 and CD8 TCR Vβ repertoires during the acute phase of Trypanosoma cruzi infection in a resistant mouse strain (C57BL/6). No major changes were found in the Vfl TCR...
Grandien, Alf, Coutinho, Antonio, Andersson, Jan, Freitas, Antonio A.
VH gene family expression in single cells of the emergent, available and actual B cell repertoires of C57BL/6 mice was compared to that of two immunoglobulln (lg)-transgenic B6 lines (B6-Sp6 and...
Ribelro, Adilia Dos Santos, Arala-Chaves, Mário Passalaqua, Vilanova, Manuel, Porto, Maria Teresa, Coutinho, Antonio
Some immunobiological aspects of host responses to an Immunosuppressive protein (p36) released by porcine monocytes upon Infection with African swine fever virus were analysed in a murine system....
Cellular basis for the age-associated increase in autoimmune reactions (1990)
Weksler, Marc E., Schwab, Rise, Huetz, Francois, Kim, Young Tai, Coutinho, Antonio
The mechanisms that lead to the increased expression of autoantibodies with age are poorly understood. We have studied the number, size, and density of spleen and peritoneal cells from young and old...
Freitas, Antonio A., Andrade, Luiz, Lembezat, Marie-Pierre, Coutinho, Antonio, Honjo, T.
In the present study we have compared by in situ hybridization and by a CFU-B colony assay VH family usage in the pre-B and B cell compartments of the bone marrow of adult BALB/c and C57BL/6...
Bernabé, Rosa R., Coutinho, Antonio, Martínez-Alonso, Carlos, Cazenave, Pierre-André
El copyright pertenece a The Rockefeller University Press
Thomas-Vaslin, Véronique, Damotte, Diane, Coltey, Monique, Le Douarin, Nicole M., Coutinho, Antonio, Salaün, Josselyne
To investigate the role of primary T cell repertoire selection in the immunopathogenesis of autoimmune diseases, pure thymic epithelium (TE) from nonobese diabetic (NOD) embryos was grafted into non...
As decades of research have resulted in few clinical applications, it is time to think about new research strategies to understand the workings of the immune system
Thomas-Vaslin, Véronique, Damotte, Diane, Coltey, Monique, Le Douarin, Nicole M., Coutinho, Antonio, Salaün, Josselyne
To investigate the role of primary T cell repertoire selection in the immunopathogenesis of autoimmune diseases, pure thymic epithelium (TE) from nonobese diabetic (NOD) embryos was grafted into non...
As decades of research have resulted in few clinical applications, it is time to think about new research strategies to understand the workings of the immune system
Coutinho, Antonio, Gronowicz, Eva, Bullock, Wesley W., Möller, Göran
The present experiments were performed in order to analyze the mechanism by which thymus-independent antigens (nonspecific B-cell mitogens) can induce specific immune responses to antigenic...
Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
Seixas, Elsa, Gozzelino, Raffaella, Chora, Ângelo, Ferreira, Ana, Silva, Gabriela, Larsen, Rasmus, ...
Infection by Plasmodium, the causative agent of malaria, is associated with hemolysis and therefore with release of hemoglobin from RBC. Under inflammatory conditions, cell-free hemoglobin can be...