Designing amino acid residues with single-conformations (2006)
Tran, Tran T., Treutlein, Herbert, Burgess, Antony W.
Drug design can benefit from the use of non-coded amino acids, such as α-amino isobutyric acids (Aib) or sarcosine (N-methyl-glycine). Non-coded amino acids can confer resistance to enzymatic...
Designing amino acid residues with single-conformations (2006)
Tran, Tran T., Treutlein, Herbert, Burgess, Antony W.
Drug design can benefit from the use of non-coded amino acids, such as α-amino isobutyric acids (Aib) or sarcosine (N-methyl-glycine). Non-coded amino acids can confer resistance to enzymatic...
Epidermal growth factor and transforming growth factor {alpha} (1989)
This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth factors α (TGFα), biosynthesis and tissue distribution of these...
Walker, Francesca, Kato, Akiko, Gonez, L. Jorge, Hibbs, Margaret L., Pouliot, Normand, Levitzki, Alexander, ...
Signalling by the epidermal growth factor (EGF) receptor (EGFR) has been studied intensively, but for most cell types the analysis is complicated by the fact that EGFR not only homodimerizes but can...
Johns, Terrance G., Luwor, Rodney B., Murone, Carmel, Walker, Francesca, Weinstock, Janet, Vitali, Angela A., ...
Blockade of epidermal growth factor receptor (EGFR) signaling with specific inhibitors of the EGFR tyrosine kinase retards cellular proliferation and arrests the growth of tumor xenografts. AG1478,...
Shipman, Lester L., Burgess, Antony W., Scheraga, Harold A.
An empirical potential energy function based on the interactions of the electrons and nuclei in molecules has been developed and tested. The potential energy of interaction is approximated by the sum...
Conformational Analysis of Thyrotropin Releasing Factor
Burgess, Antony W., Momany, Frank A., Scheraga, Harold A.
Conformational energy calculations on thyrotropin releasing factor and on several of its analogues indicate that the central histidyl residue of the native molecule is in an extended conformation....
Burgess, Antony W., Metcalf, Donald, Russell, Sue H. M., Nicola, Nicos A.
The formation of mature haemopoietic cells is controlled by hormones that specifically stimulate the progenitor cells of the granulocyte/macrophage, eosinophil, megakaryocyte and erythroid pathways....
Walker, Francesca, Kato, Akiko, Gonez, L. Jorge, Hibbs, Margaret L., Pouliot, Normand, Levitzki, Alexander, ...
Signalling by the epidermal growth factor (EGF) receptor (EGFR) has been studied intensively, but for most cell types the analysis is complicated by the fact that EGFR not only homodimerizes but can...
Johns, Terrance G., Luwor, Rodney B., Murone, Carmel, Walker, Francesca, Weinstock, Janet, Vitali, Angela A., ...
Blockade of epidermal growth factor receptor (EGFR) signaling with specific inhibitors of the EGFR tyrosine kinase retards cellular proliferation and arrests the growth of tumor xenografts. AG1478,...
Shipman, Lester L., Burgess, Antony W., Scheraga, Harold A.
An empirical potential energy function based on the interactions of the electrons and nuclei in molecules has been developed and tested. The potential energy of interaction is approximated by the sum...
Conformational Analysis of Thyrotropin Releasing Factor
Burgess, Antony W., Momany, Frank A., Scheraga, Harold A.
Conformational energy calculations on thyrotropin releasing factor and on several of its analogues indicate that the central histidyl residue of the native molecule is in an extended conformation....
Burgess, Antony W., Metcalf, Donald, Russell, Sue H. M., Nicola, Nicos A.
The formation of mature haemopoietic cells is controlled by hormones that specifically stimulate the progenitor cells of the granulocyte/macrophage, eosinophil, megakaryocyte and erythroid pathways....
Scott, Andrew M., Lee, Fook-Thean, Tebbutt, Niall, Herbertson, Rebecca, Gill, Sanjeev S., Liu, Zhanqi, ...
An array of cell-surface antigens expressed by human cancers have been identified as targets for antibody-based therapies. The great majority of these antibodies do not have specificity for cancer...
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
Garrett, Thomas P. J., Burgess, Antony W., Gan, Hui K., Luwor, Rod B., Cartwright, Glenn, Walker, Francesca, ...
Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in part by interference from the EGFR on...