Growth arrest by the LKB1 tumor suppressor: induction of p21WAF1/CIP1 (2002)
Tiainen, Marianne, Vaahtomeri, Kari, Ylikorkala, Antti, Mäkelä, Tomi P.
Germline mutations of the LKB1 tumor suppressor gene lead to Peutz–Jeghers syndrome (PJS), with a predisposition to cancer. LKB1 encodes for a nuclear and cytoplasmic serine/threonine kinase,...
Growth suppression by Lkb1 is mediated by a G1 cell cycle arrest
Tiainen, Marianne, Ylikorkala, Antti, Mäkelä, Tomi P.
Germ-line mutations of LKB1 (STK11) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of...
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
Growth suppression by Lkb1 is mediated by a G1 cell cycle arrest
Tiainen, Marianne, Ylikorkala, Antti, Mäkelä, Tomi P.
Germ-line mutations of LKB1 (STK11) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of...
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...