Anup Datta

Inner core assembly and structure of the lipooligosaccharide of Neisseria meningitidis: capacity of strain NMB to express all known immunotype epitopes (2005)

Kahler, Charlene M., Datta, Anup, Tzeng, Yih-ling, Carlson, Russell W., Stephens, David S.

Neisseria meningitidis expresses a heterogeneous population of lipooligosaccharide (LOS) inner cores variously substituted with α1-3-linked glucose and O-3, O-6, and O-7 linked phosphoethanolamine...

Inner core assembly and structure of the lipooligosaccharide of Neisseria meningitidis: capacity of strain NMB to express all known immunotype epitopes (2004)

Kahler, Charlene M., Datta, Anup, Tzeng, Yih-ling, Carlson, Russell, Stephens, David

Neisseria meningitidis expresses a heterogeneous population of lipooligosaccharide 3 (LOS) inner cores variously substituted with α1-3 linked glucose and O-3, O-6, and O-7 linked phosphoethanolamine...

Inner core assembly and structure of the lipooligosaccharide of Neisseria meningitidis: capacity of strain NMB to express all known immunotype epitopes (2004)

Kahler, Charlene M., Datta, Anup, Tzeng, Yih-ling, Carlson, Russell, Stephens, David

Neisseria meningitidis expresses a heterogeneous population of lipooligosaccharide 3 (LOS) inner cores variously substituted with α1-3 linked glucose and O-3, O-6, and O-7 linked phosphoethanolamine...

WbjA Adds Glucose To Complete the O-Antigen Trisaccharide Repeating Unit of the Lipopolysaccharide of Pseudomonas aeruginosa Serogroup O11

Dean, Charles R., Datta, Anup, Carlson, Russell W., Goldberg, Joanna B.

Lipopolysaccharide from a wbjA mutant, deficient in a putative glycosyltransferase from Pseudomonas aeruginosa serogroup O11, was compared to that from an O-antigen polymerase mutant. Results suggest...

Endotoxin of Neisseria meningitidis Composed Only of Intact Lipid A: Inactivation of the Meningococcal 3-Deoxy-d-Manno-Octulosonic Acid Transferase

Tzeng, Yih-Ling, Datta, Anup, Kolli, V. Kumar, Carlson, Russell W., Stephens, David S.

Lipopolysaccharide, lipooligosaccharide (LOS), or endotoxin is important in bacterial survival and the pathogenesis of gram-negative bacteria. A necessary step in endotoxin biosynthesis is...

A Rhizobium leguminosarum AcpXL Mutant Produces Lipopolysaccharide Lacking 27-Hydroxyoctacosanoic Acid

Vedam, Vinata, Kannenberg, Elmar L., Haynes, Janine G., Sherrier, D. Janine, Datta, Anup, Carlson, Russell W.

The structure of the lipid A from Rhizobium etli and Rhizobium leguminosarum lipopolysaccharides (LPSs) lacks phosphate and contains a galacturonosyl residue at its 4′ position, an acylated...

Neisseria meningitidis Lipooligosaccharide Structure-Dependent Activation of the Macrophage CD14/Toll-Like Receptor 4 Pathway

Zughaier, Susu M., Tzeng, Yih-Ling, Zimmer, Shanta M., Datta, Anup, Carlson, Russell W., Stephens, David S.

Meningococcal lipopoly(oligo)saccharide (LOS) is a major inflammatory mediator of fulminant meningococcal sepsis and meningitis. Highly purified wild-type meningococcal LOS and LOS from genetically...

Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids

Ferguson, Gail P., Datta, Anup, Baumgartner, John, Roop, R. Martin, Carlson, Russ W., Walker, Graham C.

Sinorhizobium meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian pathogen, both require the bacterial-encoded BacA protein to establish chronic intracellular...

Reconstitution of O-Specific Lipopolysaccharide Expression in Burkholderia cenocepacia Strain J2315, Which Is Associated with Transmissible Infections in Patients with Cystic Fibrosis†

Ortega, Ximena, Hunt, Tracey A., Loutet, Slade, Vinion-Dubiel, Arlene D., Datta, Anup, Choudhury, Biswa, ...

Burkholderia cenocepacia is an opportunistic bacterium that infects patients with cystic fibrosis. B. cenocepacia strains J2315, K56-2, C5424, and BC7 belong to the ET12 epidemic clone, which is...

Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

Zughaier, Susu M., Zimmer, Shanta M., Datta, Anup, Carlson, Russell W., Stephens, David S.

The biological response to endotoxin mediated through the Toll-like receptor 4 (TLR4)-MD-2 receptor complex is directly related to lipid A structure or configuration. Endotoxin structure may also...

The Pea Nodule Environment Restores the Ability of a Rhizobium leguminosarum Lipopolysaccharide acpXL Mutant To Add 27-Hydroxyoctacosanoic Acid to Its Lipid A

Vedam, Vinata, Kannenberg, Elmar, Datta, Anup, Brown, Dusty, Haynes-Gann, Janine G., Sherrier, D. Janine, ...

Members of the Rhizobiaceae contain 27-hydroxyoctacosanoic acid (27OHC28:0) in their lipid A. A Rhizobium leguminosarum 3841 acpXL mutant (named here Rlv22) lacking a functional specialized acyl...

Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

Zughaier, Susu M., Zimmer, Shanta M., Datta, Anup, Carlson, Russell W., Stephens, David S.

WbjA Adds Glucose To Complete the O-Antigen Trisaccharide Repeating Unit of the Lipopolysaccharide of Pseudomonas aeruginosa Serogroup O11

Dean, Charles R., Datta, Anup, Carlson, Russell W., Goldberg, Joanna B.

Lipopolysaccharide from a wbjA mutant, deficient in a putative glycosyltransferase from Pseudomonas aeruginosa serogroup O11, was compared to that from an O-antigen polymerase mutant. Results suggest...

Endotoxin of Neisseria meningitidis Composed Only of Intact Lipid A: Inactivation of the Meningococcal 3-Deoxy-d-Manno-Octulosonic Acid Transferase

Tzeng, Yih-Ling, Datta, Anup, Kolli, V. Kumar, Carlson, Russell W., Stephens, David S.

Lipopolysaccharide, lipooligosaccharide (LOS), or endotoxin is important in bacterial survival and the pathogenesis of gram-negative bacteria. A necessary step in endotoxin biosynthesis is...

A Rhizobium leguminosarum AcpXL Mutant Produces Lipopolysaccharide Lacking 27-Hydroxyoctacosanoic Acid

Vedam, Vinata, Kannenberg, Elmar L., Haynes, Janine G., Sherrier, D. Janine, Datta, Anup, Carlson, Russell W.

The structure of the lipid A from Rhizobium etli and Rhizobium leguminosarum lipopolysaccharides (LPSs) lacks phosphate and contains a galacturonosyl residue at its 4′ position, an acylated...

Neisseria meningitidis Lipooligosaccharide Structure-Dependent Activation of the Macrophage CD14/Toll-Like Receptor 4 Pathway

Zughaier, Susu M., Tzeng, Yih-Ling, Zimmer, Shanta M., Datta, Anup, Carlson, Russell W., Stephens, David S.

Meningococcal lipopoly(oligo)saccharide (LOS) is a major inflammatory mediator of fulminant meningococcal sepsis and meningitis. Highly purified wild-type meningococcal LOS and LOS from genetically...

Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids

Ferguson, Gail P., Datta, Anup, Baumgartner, John, Roop, R. Martin, Carlson, Russ W., Walker, Graham C.

Sinorhizobium meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian pathogen, both require the bacterial-encoded BacA protein to establish chronic intracellular...

Reconstitution of O-Specific Lipopolysaccharide Expression in Burkholderia cenocepacia Strain J2315, Which Is Associated with Transmissible Infections in Patients with Cystic Fibrosis†

Ortega, Ximena, Hunt, Tracey A., Loutet, Slade, Vinion-Dubiel, Arlene D., Datta, Anup, Choudhury, Biswa, ...

Burkholderia cenocepacia is an opportunistic bacterium that infects patients with cystic fibrosis. B. cenocepacia strains J2315, K56-2, C5424, and BC7 belong to the ET12 epidemic clone, which is...

Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

Zughaier, Susu M., Zimmer, Shanta M., Datta, Anup, Carlson, Russell W., Stephens, David S.

The biological response to endotoxin mediated through the Toll-like receptor 4 (TLR4)-MD-2 receptor complex is directly related to lipid A structure or configuration. Endotoxin structure may also...

The Pea Nodule Environment Restores the Ability of a Rhizobium leguminosarum Lipopolysaccharide acpXL Mutant To Add 27-Hydroxyoctacosanoic Acid to Its Lipid A

Vedam, Vinata, Kannenberg, Elmar, Datta, Anup, Brown, Dusty, Haynes-Gann, Janine G., Sherrier, D. Janine, ...

Members of the Rhizobiaceae contain 27-hydroxyoctacosanoic acid (27OHC28:0) in their lipid A. A Rhizobium leguminosarum 3841 acpXL mutant (named here Rlv22) lacking a functional specialized acyl...

Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

Zughaier, Susu M., Zimmer, Shanta M., Datta, Anup, Carlson, Russell W., Stephens, David S.

Galactose Residues on the Lipooligosaccharide of Moraxella catarrhalis 26404 Form the Epitope Recognized by the Bactericidal Antiserum from Conjugate Vaccination▿

Yu, Shengqing, Xie, Hang, Datta, Anup, Naidu, Natasha, Gu, Xin-Xing

Lipooligosaccharide (LOS) from Moraxella catarrhalis has the potential to elicit bactericidal antibodies against the pathogen. We generated LOS-based conjugate vaccines that elicited bactericidal...