Oda, Mayumi, Glass, Jacob L., Thompson, Reid F., Mo, Yongkai, Olivier, Emmanuel N., Figueroa, Maria E., ...
Many genome-wide assays involve the generation of a subset (or representation) of the genome following restriction enzyme digestion. The use of enzymes sensitive to cytosine methylation allows...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Melnick, Ari, Ahmad, K. Farid, Arai, Sally, Polinger, Adam, Ball, Helen, Borden, Katherine L., ...
The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor disrupted in patients with t(11;17)(q23;q21)-associated acute promyelocytic leukemia. PLZF contains an N-terminal...
Shaknovich, Rita, Yeyati, Patricia L., Ivins, Sarah, Melnick, Ari, Lempert, Cheryl, Waxman, Samuel, ...
The promyelocytic leukemia zinc finger (PLZF) gene, which is disrupted in therapy-resistant, t(11;17)(q23;q21)-associated acute promyelocytic leukemia (APL), is expressed in immature hematopoietic...
Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors
Melnick, Ari, Carlile, Graeme, Ahmad, K. Farid, Kiang, Chih-Li, Corcoran, Connie, Bardwell, Vivian, ...
The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to retinoic acid receptor alpha (RARα), causes a refractory form of acute promyelocytic leukemia. The highly...
Kaiso-Deficient Mice Show Resistance to Intestinal Cancer†
Prokhortchouk, Anna, Sansom, Owen, Selfridge, Jim, Caballero, Isabel M., Salozhin, Sergey, Aithozhina, Dana, ...
Kaiso is a BTB domain protein that associates with the signaling molecule p120-catenin and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA to modulate transcription. In...
Melnick, Ari, Ahmad, K. Farid, Arai, Sally, Polinger, Adam, Ball, Helen, Borden, Katherine L., ...
The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor disrupted in patients with t(11;17)(q23;q21)-associated acute promyelocytic leukemia. PLZF contains an N-terminal...
Shaknovich, Rita, Yeyati, Patricia L., Ivins, Sarah, Melnick, Ari, Lempert, Cheryl, Waxman, Samuel, ...
The promyelocytic leukemia zinc finger (PLZF) gene, which is disrupted in therapy-resistant, t(11;17)(q23;q21)-associated acute promyelocytic leukemia (APL), is expressed in immature hematopoietic...
Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors
Melnick, Ari, Carlile, Graeme, Ahmad, K. Farid, Kiang, Chih-Li, Corcoran, Connie, Bardwell, Vivian, ...
The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to retinoic acid receptor alpha (RARα), causes a refractory form of acute promyelocytic leukemia. The highly...
Kaiso-Deficient Mice Show Resistance to Intestinal Cancer†
Prokhortchouk, Anna, Sansom, Owen, Selfridge, Jim, Caballero, Isabel M., Salozhin, Sergey, Aithozhina, Dana, ...
Kaiso is a BTB domain protein that associates with the signaling molecule p120-catenin and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA to modulate transcription. In...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Polo, Jose M., Juszczynski, Przemyslaw, Monti, Stefano, Cerchietti, Leandro, Ye, Kenny, Greally, John M., ...
Diffuse large B cell lymphomas (DLBCLs) often express BCL6, a transcriptional repressor required for the formation of normal germinal centers. In a subset of DLBCLs, BCL6 is deregulated by...
CG dinucleotide clustering is a species-specific property of the genome
Glass, Jacob L., Thompson, Reid F., Khulan, Batbayar, Figueroa, Maria E., Olivier, Emmanuel N., Oakley, Erin J., ...
Cytosines at cytosine-guanine (CG) dinucleotides are the near-exclusive target of DNA methyltransferases in mammalian genomes. Spontaneous deamination of methylcytosine to thymine makes methylated...
An Integrative Genomic and Epigenomic Approach for the Study of Transcriptional Regulation
Figueroa, Maria E., Reimers, Mark, Thompson, Reid F., Ye, Kenny, Li, Yushan, Selzer, Rebecca R., ...
The molecular heterogeneity of acute leukemias and other tumors constitutes a major obstacle towards understanding disease pathogenesis and developing new targeted-therapies. Aberrant gene regulation...
CtBP Is an Essential Corepressor for BCL6 Autoregulation▿
Mendez, Lourdes M., Polo, Jose M., Yu, J. Jessica, Krupski, Melissa, Ding, B. Belinda, Melnick, Ari, ...
The transcription repressor BCL6 plays an essential role in the formation and function of germinal centers (GCs). While normal B cells promptly shut off BCL6 when they exit the GC, many GC-derived...
Sohal, Davendra, Yeatts, Andrew, Ye, Kenny, Pellagatti, Andrea, Zhou, Li, Pahanish, Perry, ...
Microarray-based studies of global gene expression (GE) have resulted in a large amount of data that can be mined for further insights into disease and physiology. Meta-analysis of these data is...
Parekh, Samir, Polo, Jose M., Shaknovich, Rita, Juszczynski, Przemyslaw, Lev, Paola, Ranuncolo, Stella M., ...
The BCL6 transcriptional repressor is the most commonly involved oncogene in diffuse large B-cell lymphomas (DLBCLs). Constitutive expression of BCL6 mediates lymphomagenesis through aberrant...
HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21
Wilson, Andrew J., Byun, Do-Sun, Nasser, Shannon, Murray, Lucas B., Ayyanar, Kanyalakshmi, Arango, Diego, ...
The class II Histone deacetylase (HDAC), HDAC4, is expressed in a tissue-specific manner, and it represses differentiation of specific cell types. We demonstrate here that HDAC4 is expressed in the...
Oda, Mayumi, Glass, Jacob L., Thompson, Reid F., Mo, Yongkai, Olivier, Emmanuel N., Figueroa, Maria E., ...
Many genome-wide assays involve the generation of a subset (or representation) of the genome following restriction enzyme digestion. The use of enzymes sensitive to cytosine methylation allows...
Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells
Polo, Jose M., Ci, Weimin, Licht, Jonathan D., Melnick, Ari
Germinal center (GC) B cells undergo somatic hypermutation, class switch recombination, and rapid clonal expansion to produce high-affinity antibodies. The BCL6 transcriptional repressor facilitates...
Ranuncolo, Stella Maris, Wang, Ling, Polo, Jose M., Dell'Oso, Tania, Dierov, Jamil, Gaymes, Terry J., ...
The BCL6 oncogenic transcriptional repressor is required for development of germinal center centroblasts, which undergo simultaneous genetic recombination and massive clonal expansion. Although BCL6...
Caldas-Lopes, Eloisi, Cerchietti, Leandro, Ahn, James H., Clement, Cristina C., Robles, Ana I., Rodina, Anna, ...
Triple-negative breast cancers (TNBCs) are defined by a lack of expression of estrogen, progesterone, and HER2 receptors. Because of the absence of identified targets and targeted therapies, and due...