Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation
Di Nardo, Ariel A., Korzhnev, Dmitry M., Stogios, Peter J., Zarrine-Afsar, Arash, Kay, Lewis E., Davidson, Alan R.
Through a mutagenic investigation of Gly-48, a highly conserved position in the Src homology 3 domain, we have discovered a series of amino acid substitutions that are highly destabilizing, yet...
Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation
Di Nardo, Ariel A., Korzhnev, Dmitry M., Stogios, Peter J., Zarrine-Afsar, Arash, Kay, Lewis E., Davidson, Alan R.
Through a mutagenic investigation of Gly-48, a highly conserved position in the Src homology 3 domain, we have discovered a series of amino acid substitutions that are highly destabilizing, yet...