Müllbacher, Arno, Waring, Paul, Tha Hla, Ron, Tran, Thao, Chin, Seow, Stehle, Thomas, ...
Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus infections. In this paper, we show that...
Hamilton-Williams, Emma E., Serreze, David V., Charlton, Brett, Johnson, Ellis A., Marron, Michele P., Müllbacher, Arno, ...
Type 1 diabetes in both humans and nonobese diabetic (NOD) mice results from T-cell-mediated autoimmune destruction of insulin-producing pancreatic β cells. Linkage studies have shown that type 1...
Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice
Müllbacher, Arno, Hla, Ron Tha, Museteanu, Crisan, Simon, Markus M.
Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased...
Momburg, Frank, Müllbacher, Arno, Lobigs, Mario
In contrast to many other viruses that escape the cellular immune response by downregulating major histocompatibility complex (MHC) class I molecules, flavivirus infection can upregulate their cell...
Balkow, Sandra, Kersten, Astrid, Tran, Thi Thanh Thao, Stehle, Thomas, Grosse, Philipp, Museteanu, Crisan, ...
Cytotoxic T lymphocytes (CTL) play a major role in the recovery from primary viral infections and the accompanying tissue injuries. However, it is unclear to what extent the two main cytolytic...
Lack of both Fas Ligand and Perforin Protects from Flavivirus-Mediated Encephalitis in Mice
Licon Luna, Rosa M., Lee, Eva, Müllbacher, Arno, Blanden, Robert V., Langman, Rod, Lobigs, Mario
The mechanism by which encephalitic flaviviruses enter the brain to inflict a life-threatening encephalomyelitis in a small percentage of infected individuals is obscure. We investigated this issue...
CD8+ T Cells Mediate Recovery and Immunopathology in West Nile Virus Encephalitis
Wang, Yang, Lobigs, Mario, Lee, Eva, Müllbacher, Arno
C57BL/6J mice infected intravenously with the Sarafend strain of West Nile virus (WNV) develop a characteristic central nervous system (CNS) disease, including an acute inflammatory reaction. Dose...
Rode, Miriam, Balkow, Sandra, Sobek, Vera, Brehm, Reina, Martin, Praxedis, Kersten, Astrid, ...
In this report we questioned the current view that the two principal cytotoxic pathways, the exocytosis and the Fas ligand (FasL)/Fas-mediated pathway, have largely nonoverlapping biological roles....
Müllbacher, Arno, Waring, Paul, Tha Hla, Ron, Tran, Thao, Chin, Seow, Stehle, Thomas, ...
Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus infections. In this paper, we show that...
Hamilton-Williams, Emma E., Serreze, David V., Charlton, Brett, Johnson, Ellis A., Marron, Michele P., Müllbacher, Arno, ...
Type 1 diabetes in both humans and nonobese diabetic (NOD) mice results from T-cell-mediated autoimmune destruction of insulin-producing pancreatic β cells. Linkage studies have shown that type 1...
Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice
Müllbacher, Arno, Hla, Ron Tha, Museteanu, Crisan, Simon, Markus M.
Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased...
Momburg, Frank, Müllbacher, Arno, Lobigs, Mario
In contrast to many other viruses that escape the cellular immune response by downregulating major histocompatibility complex (MHC) class I molecules, flavivirus infection can upregulate their cell...
Balkow, Sandra, Kersten, Astrid, Tran, Thi Thanh Thao, Stehle, Thomas, Grosse, Philipp, Museteanu, Crisan, ...
Cytotoxic T lymphocytes (CTL) play a major role in the recovery from primary viral infections and the accompanying tissue injuries. However, it is unclear to what extent the two main cytolytic...
Lack of both Fas Ligand and Perforin Protects from Flavivirus-Mediated Encephalitis in Mice
Licon Luna, Rosa M., Lee, Eva, Müllbacher, Arno, Blanden, Robert V., Langman, Rod, Lobigs, Mario
The mechanism by which encephalitic flaviviruses enter the brain to inflict a life-threatening encephalomyelitis in a small percentage of infected individuals is obscure. We investigated this issue...
CD8+ T Cells Mediate Recovery and Immunopathology in West Nile Virus Encephalitis
Wang, Yang, Lobigs, Mario, Lee, Eva, Müllbacher, Arno
C57BL/6J mice infected intravenously with the Sarafend strain of West Nile virus (WNV) develop a characteristic central nervous system (CNS) disease, including an acute inflammatory reaction. Dose...
Rode, Miriam, Balkow, Sandra, Sobek, Vera, Brehm, Reina, Martin, Praxedis, Kersten, Astrid, ...
In this report we questioned the current view that the two principal cytotoxic pathways, the exocytosis and the Fas ligand (FasL)/Fas-mediated pathway, have largely nonoverlapping biological roles....
Increased Survival after Gemfibrozil Treatment of Severe Mouse Influenza▿
Budd, Alison, Alleva, Lisa, Alsharifi, Mohammed, Koskinen, Aulikki, Smythe, Victoria, Müllbacher, Arno, ...
Gemfibrozil, an agent that inhibits production of proinflammatory cytokines in addition to its clinically useful lipid-lowering activity, increased survival in BALB/c mice that were already ill from...
Pardo, Julian, Urban, Christin, Galvez, Eva M., Ekert, Paul G., Müller, Uwe, Kwon-Chung, June, ...
Aspergillus fumigatus infections cause high levels of morbidity and mortality in immunocompromised patients. Gliotoxin (GT), a secondary metabolite, is cytotoxic for mammalian cells, but the...
Sugui, Janyce A., Pardo, Julian, Chang, Yun C., Zarember, Kol A., Nardone, Glenn, Galvez, Eva M., ...
Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production, however, suggested...
Sugui, Janyce A., Pardo, Julian, Chang, Yun C., Müllbacher, Arno, Zarember, Kol A., Galvez, Eva M., ...
The alb1 (pksP) gene has been reported as a virulence factor controlling the pigmentation and morphology of conidia in Aspergillus fumigatus. A recent report suggested that laeA regulates alb1...
Pardo, Julián, Bosque, Alberto, Brehm, Reina, Wallich, Reinhard, Naval, Javier, Müllbacher, Arno, ...
Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their physiological relevance in CTL-mediated...
Simon, Markus M., Hausmann, Michael, Tran, Thao, Ebnet, Klaus, Tschopp, Jürg, ThaHla, Ron, ...
Granzyme (gzm) A and gzmB have been implicated in Fas-independent nucleolytic and cytolytic processes exerted by cytotoxic T (Tc) cells, but the underlying mechanism(s) remains unclear. In this...