Effect of leptin on intestinal re-growth following massive small bowel resection in rat (2006)
Shiloni, Eitan, Lurie, Michael, Vadasz, Zahava, Coran, Arnold G., Hatoum, Ossama A., Mogilner, Jorge G., ...
Recent evidence suggests that the adipose tissue-derived cytokine leptin (LEP) is involved in modulation of growth and differentiation of normal small intestine. The purpose of the present study was...
Mogilner, Jorge G., Coran, Arnold G., Lurie, Michael, Sukhotnik, Igor, Nativ, Ofer, Shiloni, Eitan
Recent evidence suggests that enhanced cell apoptosis is responsible for germ cell loss following testicular ischemia-reperfusion (IR) injury. A nonsteroidal anti-inflammatory drug diclofenac sodium...
Advances in short bowel syndrome: an updated review (2005)
Kramer, Alexander, Sukhotnik, Igor, Shiloni, Eitan, Coran, Arnold G., Mogilner, Jorge G.
Short bowel syndrome (SBS) continues to be an important clinical problem due to its high mortality and morbidity as well as its devastating socioeconomic effects. The past 3 years have witnessed...
Sukhotnik, Igor, Miselevich, Iness, Nativ, Ofer, Lurie, Michael, Mogilner, Jorge G., Coran, Arnold G.
Unilateral testicular ischemia-reperfusion (IR) in the rat is followed by histologic damage in the contralateral testis, which has been previously explained on immunologic grounds. There is evidence...
Sukhotnik, Igor, Lerner, Aaron, Mogilner, Jorge G., Coran, Arnold G., Miselevich, Iness, Shiloni, Eitan, ...
The nitric oxide precursor L-arginine (ARG) has been shown to influence intestinal structure and absorptive function. It is also well known that the route of administration modulates the effects of...
Bejar, Jacob, Hirsh, Mark, Coran, Arnold G., Sukhotnik, Igor, Shehadeh, Naim, Shamir, Raanan, ...
Insulin has been shown to influence intestinal structure and absorptive function. The purpose of the present study was to evaluate the effects of parenteral insulin on structural intestinal...
Oral arginine improves intestinal recovery following ischemia-reperfusion injury in rat (2005)
Sukhotnik, Igor, Shiloni, Eitan, Mogilner, Jorge G., Helou, Habib, Coran, Arnold G., Lurie, Michael, ...
Arginine and nitric oxide are critical to the normal physiology of the gastrointestinal tract and maintain the mucosal integrity of the intestine in various intestinal disorders. In the present...
Surgery for ulcerative colitis in children (2004)
Coran, Arnold G., Rivosecchi, Massimo
Peer Reviewed
Severe esophageal damage due to button battery ingestion: can it be prevented? (2004)
Yardeni, H., Coran, Arnold G., Yardeni, D., Golladay, Eustace S.
Batteries represent less than 2% of foreign bodies ingested by children, but in the last 2 decades, the frequency has continuously increased. Most ingestions have an uneventful course, but those...
Drongowski, Robert A., Mor-Vaknin, Nirit, Miselevich, Iness, Coran, Arnold G., Harmon, Carroll M.
Among factors promoting mucosal hyperplasia after bowel resection, long-chain fatty acids may have a special role. The purpose of the present study was to evaluate the effects of high-fat diet (HFD)...
Drongowski, Robert A., Teitelbaum, Daniel H., Coran, Arnold G., Btaiche, Imad, Tazuke, Yuko
Lipids are an important component of total parenteral nutrition (TPN), contributing the largest caloric load per volume of solution and providing essential fatty acids necessary for survival....
Harmon, C. M., Mor-Vaknin, Nirit, Coran, Arnold G., Drongowski, Robert A., Sukhotnik, Igor
The aim of this study was to investigate the effect of dietary fat on the time course of changes in fat absorption and tissue and plasma lipid composition in a rat model of short bowel syndrome...
Teitelbaum, Daniel H., Wildhaber, Barbara E., Coran, Arnold G., Yang, Hua
The intestinal adaptive response [increased epithelial cell (EC) proliferation and apoptosis] after massive small bowel resection (SBR) is partially controlled by intraepithelial lymphocytes (IEL)....
Drongowski, Robert A., Teitelbaum, Daniel H., Coran, Arnold G., Tazuke, Yuko
Hypoxia has been implicated in the breakdown of the intestinal epithelial barrier in animals, leading to bacterial translocation (BT); however, the mechanism of this hypoxic insult is unknown. To...
Drongowski, Robert A., Teitelbaum, Daniel H., Tazuke, Yuko, Coran, Arnold G.
Proinflammatory cytokines and secretory phospholipase A 2 (sPLA 2 ) are elevated in patients with inflammatory bowel disease (IBD). We previously reported that the proinflammatory cytokine IL-6...
Drongowski, Robert A., Harmon, Carroll M., Sukhotnik, Igor, Gork, A. Semih, Chen, Min, Coran, Arnold G.
Long chain fatty acids (LCFAs) appear to be powerful stimulants for small bowel adaptation in patients with short bowel syndrome (SBS). However, the dietary lipid content may alter intestinal lipid...
Recurrence after laparoscopic and open Nissen fundoplication (2003)
Teitelbaum, Daniel H., Graziano, K., Coran, Arnold G., Hirschl, Ronald B., Geiger, James D., McLean, K.
Background: Laparoscopic Nissen fundoplication as treatment for gastroesophageal reflux disease (GERD) in adults has a reported recurrence rate of 2–17%. We investigated the rates and mechanisms of...
Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model (2002)
Harmon, C., Yongyi, F., Mattar, A. F., Drongowski, Robert A., Teitelbaum, Daniel H., Coran, Arnold G.
Enteral probiotics such as Lactobacillus casei GG (LGG) have been used in the treatment of a variety of intestinal disorders in infants and children, including diarrhea, malabsorption, and...
Coran, Arnold G., Segura, Bradley J., Harmon, Caroll M., Lampman, Robert W., Sawai, Toshio, Hua, Yang, ...
The activity of phospholipase A 2 (PLA 2 ) is elevated in the intestinal epithelia of patients with inflammatory bowel disease. We recently reported that PLA 2 mediates the hydrolysis of...
Harmon, Carroll M., Drongovski, Robert A., Gork, Semih A., Sukhotnik, Igor, Coran, Arnold G., Chen, Min, ...
Long-chain fatty acids (LCFA) are the major energy substrates for the heart. In short-bowel syndrome (SBS), LCFA delivery to the myocardium decreases due to fat malabsorption. Fatty-acid translocase...
Sukhotnik, Igor, Yakirevich, E., Shiloni, Eitan, Krausz, M., Kramer, Alexander, Siplovich, L., ...
Sepsis is frequently associated with or complicates short-bowel syndrome (SBS). To investigate the effects of lipopolysaccharide (LPS) endotoxemia on enterocyte proliferation and death via apoptosis...
Sporadic aplasia cutis congenita (2002)
Coran, Arnold G., Harris, Philip A., Fagan, Linda-Lynn, Cywes, Robert
Aplasia cutis congenita (ACC) is a rare group of disorders characterized by the focal absence of skin at birth. The majority of cases affect the scalp, but involvement of the trunk and extremities...
Intestinal adaptation in short-bowel syndrome in infants and children: a collective review (2002)
Sukhotnik, Igor, Shiloni, Eitan, Coran, Arnold G., Siplovich, L., Mor-Vaknin, Nirit, Harmon, C. M.
Peer Reviewed
Gastric Secretory Response to Acute Isotonic Hypervolemia. (2002)
Kraft,Avram R., Coran,Arnold G., Homer,Louise D., Herman,Clifford M.
The effects of acute isotonic extracellular fluid volume expansion were studied in conditioned, anesthetized dogs who underwent pyloric ligation and creation of an external gastric fistula. A...
Effect of low fat diet on lipid absorption and fatty-acid transport following bowel resection (2001)
Sukhotnik, Igor, Coran, Arnold G., Chen, M., Gork, A. Semih, Harmon, C. M., Drongowski, Robert A.
Low-fat diets (LFD) are used extensively in many different clinical conditions. However, the effect of this diet on lipid absorption and cellular long-chain fatty-acid (LCFA) transport is unknown....
Effect of probiotics on enterocyte bacterial translocation in vitro (2001)
Drongowski, Robert A., Mattar, A. F., Harmon, C. M., Coran, Arnold G.
Enteral probiotics such as Lactobacillus casei GG (LGG) have been used in the treatment of a variety of intestinal disorders in infants and children, including diarrhea, malabsorption, and...
Lampman, Robert W., Sawai, T., Harmon, C. M., Coran, Arnold G., Drongowski, Robert A.
The activity of phospholipase A 2 (PLA 2 ) is elevated in the intestinal epithelia of patients with inflammatory bowel disease (IBD). We recently reported that PLA 2 mediates hydrolysis of...
Drongowski, Robert A., Goldstone, N., Harmon, C. M., Sawai, T., Coran, Arnold G.
Intestinal secretory immunoglobulin A (sIgA) plays an important role in gut mucosal immunity in vivo; however, in-vitro enterocyte models for studying the mechanisms of these effects are lacking....
Evaluation of probiotic treatment in a neonatal animal model (2000)
Lee, D. J., Drongowski, Robert A., Harmon, C. M., Coran, Arnold G.
The clinical use of probiotic agents such as enteral Lactobacillus to enhance intestinal defense against potential luminal pathogens has been tested in vivo; however, an understanding of the...
The effect of phospholipase A2 on bacterial translocation in a cell culture model (2000)
Sawai, T., Drongowski, Robert A., Coran, Arnold G., Usui, N., Harmon, C. M., Dwaihy, J., ...
The activity of phospholipase (PL)A 2 is elevated in the intestinal epithelia of patients with inflammatory bowel disease (IBD). Recently, we reported that lysophosphatidylcholine (L-PC), the PLA...
Dermatoglyphic patterns in children with chronic constipation (1995)
Drongowski, Robert A., Coran, Arnold G.
Analysis of the fine ridge configurations on the digits of the palms and soles (dermatoglyphics) may sometimes help in the diagnoses of certain medical disorders. Dermatoglyphic patterns have been...
Interval appendectomy in perforated appendicitis (1995)
Coran, Arnold G., Drongowski, Robert A., Hirschl, Ronald B., Katz, Aviva, Weiner, Daniel J.
The treatment of the perforated appendix remains controversial, with the optimal timing of surgical intervention unclear. Previous studies have documented an increase in both minor and major...
Bacterial translocation in the newborn rabbit: effect of age on frequency of translocation (1995)
Drongowski, Robert A., Camp, J. M., Tomaselli, V., Coran, Arnold G.
Sepsis is a significant cause of morbidity and mortality in neonates, and in a significant number of cases no predisposing factors can be identified. We hypothesize that bacterial translocation (BT)...
Megacolon: an unusual presentation of malrotation (1994)
Teitelbaum, Daniel H., Uitvlugt, N., Coran, Arnold G., Olson, Allan David, Ayas, M.
This report describes a 9-year-old boy with a highly unusual variant of malrotation: massive colonic distention secondary to peritoneal bands and a localized volvulus. The presentation and treatment...
Van Camp, Joan M., Drongowski, Robert A., Gorman, Robert, Altabba, Maher, Hirschl, Ronald B., Coran, Arnold G.
Seventy-four New Zealand white rabbit pups were divided into four groups: group I, 2 days of age (n = 9); group II, 3 to 5 days of age (n = 24); group III, 6 to 8 days of age (n = 27); and group IV,...
Resolution of splenic injury after nonoperative management (1994)
Pranikoff, Thomas, Hirschl, Ronald B., Schlesinger, Alan E., Polley, Theodore Z., Coran, Arnold G.
Numerous studies have demonstrated success with nonoperative management of splenic injuries in pediatric patients. However, the resolution of the splenic injury has not been previously evaluated. The...
Steimle, Cynthia N., Meric, Funda, Hirschl, Ronald B., Bozynski, Mary Ellen A., Coran, Arnold G., Bartlett, Robert H.
Extracorporeal life support (ECLS) has been used for neonates with congenital diaphragmatic hernia (CDH) and respiratory failure at the authors' hospital since June 1981. In 1988, criteria for...
Bliss, David, Hirschl, Ronald B., Oldham, Keith T., Chey, Janine, Cilley, Robert E., Blane, Caroline E., ...
Anterior gastric fundoplication (AGF) has been performed at the University of Michigan since 1988. To objectively evaluate the long-term efficacy of the AGF, the authors performed a study of children...
Pancreatitis in children: diagnosis and etiology in 57 patients (1994)
Camp, J. M., Coran, Arnold G., Polley, Theodore Z.
Pancreatitis in children is uncommon, but can be the cause of significant morbidity. We undertook this study to review recent changes in the management of pediatric pancreatitis. Between 1974 and...
Resolving cavitary pnemonia presenting as late-onset congenital diaphragmatic hernia (1994)
Elhalaby, Essam A., Hirschl, Ronald B., Coran, Arnold G., Schlesinger, Alan E.
An unusual case of resolving left lower lobe pneumonia associated with pleural effusion is reported. The plain radiographs and chest CT were initially misinterpreted as showing a late-presenting...
Hennein, Hani A., Mendeloff, Eric N., Cilley, Robert E., Bove, Edward L., Coran, Arnold G.
This study was undertaken to evaluate factors predictive of postoperative outcome after general surgical (GS) procedures in patients with congenital heart disease (CHD). All patients with a diagnosis...
Elhalaby, E., Coran, Arnold G., Blane, Caroline E.
The enterocolitis following a pull-through in Hirschsprung's disease can be life-threatening and difficult to distinguish clinically from gastroenteritis and post-operative complications. We reviewed...
Fundoplication in 160 children under 2 years of age (1994)
Kazerooni, Nina L., Van Camp, Joan M., Hirschl, Ronald B., Drongowski, Robert A., Coran, Arnold G.
The natural history of fundoplication in young children with gastroesophageal reflux (GER) had not been analyzed previously. The authors reviewed the charts of 160 children who underwent gastric...
El-Halaby, Essam, Coran, Arnold G.
The cases of three full-term infant girls with both Hirschsprung's disease (HD) and Ondine's curse (OC) are presented, and the relevant literature is reviewed. All three patients required...
Trauma scores, accident deformity codes, and car restraints in children (1993)
Drongowski, Robert A., Coran, Arnold G., Maio, Ronald F.
The importance and effectiveness of the appropriate use of automobile restraints by young children has been emphasized in several studies. Once the child has entered the emergency care system,...
Lung injury produced by moderate lung overinflation in rats (1993)
Cilley, Robert E., Wang, James Y., Coran, Arnold G.
In models using both intact animals and isolated lungs of rats, rabbits, lambs, and dogs, application of high airway pressure and resultant lung overdistension has been shown to cause lung injury....
Coran, Arnold G., Drongowski, Robert A., Paik, Jane J., Remick, Daniel G.
This study was undertaken to evaluate the effect of a cyclooxygenase inhibitor, ibuprofen, at various time intervals in a live Escherichia coli model of canine septic shock. Group I (control) animals...
Hypoxia-induced bacterial translocation in the puppy (1992)
Drongowski, Robert A., Coran, Arnold G., Abrams, Gerald D.
Because hypoxia is one of the most common major stresses to which a neonate is exposed, we postulated that it alone might be the cause of intestinal bacterial translocation, which could be the...
Coran, Arnold G., Drongowski, Robert A., Ha, Hyun J., Bartlett, Robert H.
After being placed on extracorporeal life support (ECLS), newborn patients typically weight 5% to 30% more than their birthweight. Recovery and eventual decannulation from ECLS is associated with a...
Wheatley, Michael J., Coran, Arnold G.
From 1974 to 1988, six children with fistula recurrence following primary tracheoesophageal fistula (TEF) repair have been managed at our hospital. Reclosure of the fistula with pleural flap...
Intestinal vaginoplasty for congenital absence of the vagina (1992)
Wesley, John R., Coran, Arnold G.
Congenital absence of the vagina is rare and occurs as a result of aplasia of the Mullerian ducts (46,XX) or complete androgen insensitivity syndrome (AIS--46,XY). Both syndromes are associated with...
The role of surgery in American Burkitt's lymphoma in children (1991)
Stovroff, Mark C., Coran, Arnold G., Hutchinson, Raymond J.
The records of 28 children with the pathological diagnosis of American Burkitt's lymphoma were reviewed. Twenty-three of these children (82%) presented with primary abdominal tumors and 5 with...
Redo fundoplication in infants and children with recurrent gastroesophageal reflux (1991)
Wheatley, Michael J., Coran, Arnold G., Wesley, John R., Oldham, Keith T., Turnage, Richard H.
The Nissen fundoplication is well established as the surgical treatment for medically refractory gastroesophageal reflux (GER) in childhood. Recurrent GER following fundoplication is a challenging...
Surgical management of ambiguous genitalia in the infant and child (1991)
Proper gender assignment to a neonate born with ambiguous genitalia is a social emergency of the newborn period. Once an appropriate sex assignment has been made, the next critical step is...
Wheatley, Michael J., Wesley, John R., Tkach, Daniel M., Coran, Arnold G.
Due to the frequent presence of latent gastroesophageal reflux (GER) in mentally impaired children, it is now standard to perform upper gastrointestinal contrast (UGI) and pH probe studies in all...
Donn, Steven M., Zak, Linda K., Bozynski, Mary Ellen A., Coran, Arnold G., Oldham, Keith T.
Two preterm infants (28 weeks, 960 g; 32 weeks, 1,870 g) with very large tracheoesophageal fistulas suffered from respiratory distress syndrome and falled to respond to conventional mechanical...
Pyloric stenosis: evolution from pylorospasm? (1990)
Wesley, John R., DiPietro, Michael A., Coran, Arnold G.
Over a 10-year period, we have performed pyloromyotomy on 260 infants with hypertrophic pyloric stenosis (HPS), 10 of whom had a history suggestive of pyloric stenosis but initially had neither the...
Extracorporeal life support (ECLS) for pediatric trauma: experience with five cases (1990)
Oldham, Keith T., Coran, Arnold G., Anderson, Harry L., Bartlett, Robert H., Chapman, Robin A., Schmeling, David J., ...
Extracorporeal life support (ECLS) was used to treat five pediatric trauma patients (ages 1 to 17 years) with respiratory failure unresponsive to conventional mechanical ventilation. Diagnoses in...
The hormonal and metabolic response to stress in the neonate (1990)
Coran, Arnold G., Schmeling, David J.
It is apparent that adult patients demonstrate a catabolic response to the stresses induced by operative or accidental trauma. It seems that the degree of this catabolic response may be...
Hirschsprung's disease in adolescents and adults (1990)
Wheatley, Michael J., Polley, Theodore Z., Wesley, John R., Coran, Arnold G.
Hirschsprung's disease in the adolescent and adult is a rare and often misdiagnosed cause of lifelong refractory constipation. Two adolescent and three adult patients with Hirschsprung's disease...
Long-term radiographic follow-up of the Nissen fundoplication in children (1989)
Blane, Caroline E., Coran, Arnold G., Turnage, Richard H., Oldham, Keith T.
This study examined 46 children 5–9 years (mean 6.7) after Nissen fundoplication surgery for gastroesophageal reflux (GER). Eleven were deceased and ten of the 35 families declined objective...
Follow-up imaging of benign pediatric liver tumors (1989)
Coran, Arnold G., Blane, Caroline E., Weiskittel, Deborah A., Leary, Dana L.
Though surgery has been recommended in the past for the management of benign hepatic tumors, the current emphasis is on medical management. This report of 4 cases with long-term (8–28 months)...
Body fluid compartment changes following cardiopulmonary bypass in dogs (1988)
Manning, Peter B., Morgan, Ross A., Coran, Arnold G., Behrendt, Douglas M., Polley, Theodore Z., Buckley, John T., ...
To investigate whether pulsatile perfusion affects postoperative edema, we examined weight, total body water (TBW), and extracellular fluid (ECF) following cardiopulmonary bypass (CPB) in dogs using...
Esophageal and tracheobronchial foreign bodies in infants and children (1987)
Manning, Peter B., Polley, Theodore Z., Coran, Arnold G., Wesley, John R.
In an effort to improve the diagnosis and management of children with aspiration or ingestion of foreign bodies we reviewed 100 consecutive cases of esophageal (49) or tracheobronchial (51) foreign...
Synchronous bilateral Wilm's tumor in the adolescent and adult (1987)
Polley, Theodore Z., Manning, Peter B., Coran, Arnold G.
Bilateral Wilms' tumor in the adolescent and adult is extremely rare, with only four previous cases reported. Theories as to the etiology of this entity and a review of the demographics, diagnosis,...