Deziel, Mark R., Heine, Henry, Louie, Arnold, Kao, Mark, Byrne, WIlliam R., Basset, Jennifer, ...
Expanded options for treatments directed against pathogens that can be used for bioterrorism are urgently needed. Treatment regimens directed against such pathogens can be identified only by using...
Louie, Arnold, Liu, Weiguo, Miller, Dorothy A., Sucke, Alana C., Liu, Qing-Feng, Drusano, George L., ...
We compared the efficacies of fluconazole (Flu), amphotericin B (AmB), and 5-fluorocytosine (5FC) monotherapies with the combination of Flu plus 5FC and Flu plus AmB in a rabbit model of Candida...
Louie, Arnold, Banerjee, Partha, Drusano, George L., Shayegani, Mehdi, Miller, Michael H.
The interaction between fluconazole (Flu) and amphotericin B (AmB) was evaluated in a murine model of systemic candidiasis for one Flu-susceptible strain (MIC, 0.5 μg/ml), two strains with...
Louie, Arnold, Kaw, Pamela, Banerjee, Partha, Liu, Weiguo, Chen, George, Miller, Michael H.
In vitro time-kill studies and a rabbit model of endocarditis and pyelonephritis were used to define the impact that the order of exposure of Candida albicans to fluconazole (FLC) and amphotericin B...
Pharmacodynamics of Daptomycin in a Murine Thigh Model of Staphylococcus aureus Infection
Louie, Arnold, Kaw, Pamela, Liu, Weiguo, Jumbe, Nelson, Miller, Michael H., Drusano, George L.
Daptomycin is a lipopeptide antibiotic with activity against gram-positive bacteria, including Staphylococcus aureus. We defined the pharmacodynamic parameters that determine the activity of...
Liu, Weiguo, Liu, Qing Feng, Perkins, Ruth, Drusano, George, Louie, Arnold, Madu, Assumpta, ...
We have used a recently described animal model to characterize the ocular pharmacokinetics of sparfloxacin in vitreous humor of uninfected albino rabbits following systemic administration and direct...
Louie, Arnold, Liu, Qing-Feng, Drusano, George L., Liu, Weiguo, Mayers, Martin, Anaissie, Elias, ...
We conducted steady-state pharmacokinetic studies with high-dose fluconazole with rabbits and human volunteers. We then derived mathematical equations that predict the doses of fluconazole that...
Pharmacodynamics of Fluconazole in a Murine Model of Systemic Candidiasis
Louie, Arnold, Drusano, George L., Banerjee, Partha, Liu, Qing-Feng, Liu, Weiguo, Kaw, Pamela, ...
In this study we defined the pharmacodynamic parameter that optimizes outcome in deep-seated Candida albicans infections treated with fluconazole. Using a murine model of systemic candidiasis, we...
Miller, Kenneth, Louie, Arnold, Baltch, Aldona L., Smith, Raymond P., Davis, Patrick J., Gordon, Morris A.
Pentoxifylline has immunomodulatory properties and has been shown to decrease organ damage and improve survival in animals with gram-negative sepsis or endotoxemia. This effect is mediated by a...
Jumbe, Nelson, Louie, Arnold, Leary, Robert, Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...
The worldwide increase in the prevalence of multi-antibiotic–resistant bacteria has threatened the physician’s ability to provide appropriate therapy for infections. The relationship between...
Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Drusano, George L.
Studies of early bactericidal activity provide a fast and economic way to evaluate the clinical efficacy of potential agents for the treatment of tuberculosis. Based on good early bactericidal...
Louie, Arnold, Deziel, Mark, Liu, Weiguo, Drusano, Michael F., Gumbo, Tawanda, Drusano, George L.
Pharmacokinetic and pharmacodynamic studies were conducted in a murine model of systemic candidiasis to determine the pharmacodynamic parameter linked with caspofungin efficacy. Additional studies...
Deziel, Mark R., Heine, Henry, Louie, Arnold, Kao, Mark, Byrne, William R., Basset, Jennifer, ...
Expanded options for treatments directed against pathogens that can be used for bioterrorism are urgently needed. Treatment regimens directed against such pathogens can be identified only by using...
Jumbe, Nelson L., Louie, Arnold, Miller, Michael H., Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...
The preferential use of older antimicrobial agents is, in general, sound public health policy and is meant to maintain susceptibility to newer agents. In the case of fluoroquinolones, however, this...
Louie, Arnold, Liu, Weiguo, Miller, Dorothy A., Sucke, Alana C., Liu, Qing-Feng, Drusano, George L., ...
We compared the efficacies of fluconazole (Flu), amphotericin B (AmB), and 5-fluorocytosine (5FC) monotherapies with the combination of Flu plus 5FC and Flu plus AmB in a rabbit model of Candida...
Louie, Arnold, Banerjee, Partha, Drusano, George L., Shayegani, Mehdi, Miller, Michael H.
The interaction between fluconazole (Flu) and amphotericin B (AmB) was evaluated in a murine model of systemic candidiasis for one Flu-susceptible strain (MIC, 0.5 μg/ml), two strains with...
Louie, Arnold, Kaw, Pamela, Banerjee, Partha, Liu, Weiguo, Chen, George, Miller, Michael H.
In vitro time-kill studies and a rabbit model of endocarditis and pyelonephritis were used to define the impact that the order of exposure of Candida albicans to fluconazole (FLC) and amphotericin B...
Pharmacodynamics of Daptomycin in a Murine Thigh Model of Staphylococcus aureus Infection
Louie, Arnold, Kaw, Pamela, Liu, Weiguo, Jumbe, Nelson, Miller, Michael H., Drusano, George L.
Daptomycin is a lipopeptide antibiotic with activity against gram-positive bacteria, including Staphylococcus aureus. We defined the pharmacodynamic parameters that determine the activity of...
Liu, Weiguo, Liu, Qing Feng, Perkins, Ruth, Drusano, George, Louie, Arnold, Madu, Assumpta, ...
We have used a recently described animal model to characterize the ocular pharmacokinetics of sparfloxacin in vitreous humor of uninfected albino rabbits following systemic administration and direct...
Louie, Arnold, Liu, Qing-Feng, Drusano, George L., Liu, Weiguo, Mayers, Martin, Anaissie, Elias, ...
We conducted steady-state pharmacokinetic studies with high-dose fluconazole with rabbits and human volunteers. We then derived mathematical equations that predict the doses of fluconazole that...
Pharmacodynamics of Fluconazole in a Murine Model of Systemic Candidiasis
Louie, Arnold, Drusano, George L., Banerjee, Partha, Liu, Qing-Feng, Liu, Weiguo, Kaw, Pamela, ...
In this study we defined the pharmacodynamic parameter that optimizes outcome in deep-seated Candida albicans infections treated with fluconazole. Using a murine model of systemic candidiasis, we...
Miller, Kenneth, Louie, Arnold, Baltch, Aldona L., Smith, Raymond P., Davis, Patrick J., Gordon, Morris A.
Pentoxifylline has immunomodulatory properties and has been shown to decrease organ damage and improve survival in animals with gram-negative sepsis or endotoxemia. This effect is mediated by a...
Jumbe, Nelson, Louie, Arnold, Leary, Robert, Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...
The worldwide increase in the prevalence of multi-antibiotic–resistant bacteria has threatened the physician’s ability to provide appropriate therapy for infections. The relationship between...
Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Drusano, George L.
Studies of early bactericidal activity provide a fast and economic way to evaluate the clinical efficacy of potential agents for the treatment of tuberculosis. Based on good early bactericidal...
Louie, Arnold, Deziel, Mark, Liu, Weiguo, Drusano, Michael F., Gumbo, Tawanda, Drusano, George L.
Pharmacokinetic and pharmacodynamic studies were conducted in a murine model of systemic candidiasis to determine the pharmacodynamic parameter linked with caspofungin efficacy. Additional studies...
Deziel, Mark R., Heine, Henry, Louie, Arnold, Kao, Mark, Byrne, William R., Basset, Jennifer, ...
Expanded options for treatments directed against pathogens that can be used for bioterrorism are urgently needed. Treatment regimens directed against such pathogens can be identified only by using...
Jumbe, Nelson L., Louie, Arnold, Miller, Michael H., Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...
The preferential use of older antimicrobial agents is, in general, sound public health policy and is meant to maintain susceptibility to newer agents. In the case of fluoroquinolones, however, this...
Gumbo, Tawanda , Drusano, George L., Liu, Weiguo, Ma, Lei, Deziel, Mark R., Drusano, Michael F. , ...
Candidemia is often fatal, especially in patients with persistent neutropenia. New therapies are needed. We performed 24-h pharmacodynamic studies to compare the efficacies of anidulafungin,...
Hope, William W., Warn, Peter A., Sharp, Andrew, Howard, Susan, Kasai, Miki, Louie, Arnold, ...
Drug exposure or pharmacodynamic breakpoints refer to a magnitude of drug exposure which separates a population into groups with high and low probabilities of attaining a desired outcome. We used a...
Hope, William W., Drusano, George L., Moore, Caroline B., Sharp, Andrew, Louie, Arnold, Walsh, Thomas J., ...
Disseminated candidiasis is associated with a high rate of morbidity and mortality. The presence of neutrophils and the timely administration of antifungal agents are likely to be critical factors...
Tam, Vincent H., Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Drusano, George L.
We determined the relationship between garenoxacin exposure and quinolone-resistant subpopulations for three bacterial isolates in an in vitro hollow-fiber infection model. An “inverted-U”...
Gumbo, Tawanda, Drusano, George L., Liu, Weiguo, Kulawy, Robert W., Fregeau, Christine, Hsu, Vasha, ...
The effect of micafungin dose scheduling on the treatment of candidemia is unknown. Neutropenic mice with disseminated Candida glabrata infection were treated with single intraperitoneal micafungin...
Gumbo, Tawanda, Louie, Arnold, Liu, Weiguo, Brown, David, Ambrose, Paul G., Bhavnani, Sujata M., ...
Isoniazid, administered as part of combination antituberculosis therapy, is responsible for most of the early bactericidal activity (EBA) of the regimen. However, the emergence of Mycobacterium...
Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Drusano, George L.
Yersinia pestis, the bacterium that causes plague, is a potential agent of biowarfare and bioterrorism. The aminoglycoside antibiotic streptomycin is the gold standard for treatment. However, this...
Hope, William W., Warn, Peter A., Sharp, Andrew, Reed, Paul, Keevil, Brian, Louie, Arnold, ...
Amphotericin B and flucytosine (5FC) have an additive effect when used for disseminated candidiasis. Here, we bridge the results of an experimental pharmacodynamic study to humans and demonstrate...
Louie, Arnold, Brown, David L., Liu, Weiguo, Kulawy, Robert W., Deziel, Mark R., Drusano, George L.
The prevalence of fluoroquinolone-resistant Streptococcus pneumoniae is slowly rising as a consequence of the increased use of fluoroquinolone antibiotics to treat community-acquired pneumonia. We...
Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin▿
Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Parsons, Linda M., Salfinger, Max, ...
Rifampin is a cornerstone of modern antituberculosis therapy. However, rifampin's half-life of 3 h is believed to limit its utility for intermittent therapy, so new congeners with long half-lives are...