Ganusov, Vitaly V., Lukacher, Aron E., Byers, Anthony M.
Viral infections can be broadly divided into infections that are cleared from the host (acute) and those that persist (chronic). Why some viruses establish chronic infections while other do not is...
Kemball, Christopher C., Lee, Eun D. Han, Szomolanyi-Tsuda, Eva, Pearson, Thomas A., Larsen, Christian P., Lukacher, Aron E.
The requirement for costimulation in antiviral CD8+ T cell responses has been actively investigated for acutely resolved viral infections, but it is less defined for CD8+ T cell responses to...
Polyomavirus-Infected Dendritic Cells Induce Antiviral CD8+ T Lymphocytes
Drake, Donald R., Moser, Janice M., Hadley, Annette, Altman, John D., Maliszewski, Charles, Butz, Eric, ...
CD8+ T cells are critical for the clearance of acute polyomavirus infection and the prevention of polyomavirus-induced tumors, but the antigen-presenting cell(s) involved in generating...
Induction of Polyomavirus-Specific CD8+ T Lymphocytes by Distinct Dendritic Cell Subpopulations
Drake, Donald R., Shawver, Mandy L., Hadley, Annette, Butz, Eric, Maliszewski, Charles, Lukacher, Aron E.
Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset...
Polyomavirus-Infected Dendritic Cells Induce Antiviral CD8+ T Lymphocytes
Drake, Donald R., Moser, Janice M., Hadley, Annette, Altman, John D., Maliszewski, Charles, Butz, Eric, ...
CD8+ T cells are critical for the clearance of acute polyomavirus infection and the prevention of polyomavirus-induced tumors, but the antigen-presenting cell(s) involved in generating...
Induction of Polyomavirus-Specific CD8+ T Lymphocytes by Distinct Dendritic Cell Subpopulations
Drake, Donald R., Shawver, Mandy L., Hadley, Annette, Butz, Eric, Maliszewski, Charles, Lukacher, Aron E.
Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset...
Vezys, Vaiva, Masopust, David, Kemball, Christopher C., Barber, Daniel L., O'Mara, Leigh A., Larsen, Christian P., ...
Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T cell activation. Pathogen-specific T cells in chronically infected hosts are often phenotypically and...
Kemball, Christopher C., Szomolanyi-Tsuda, Eva, Lukacher, Aron E.
CD4+ T-cell help enables antiviral CD8+ T cells to differentiate into fully competent memory cells and sustains CD8+ T-cell-mediated immunity during persistent virus infection. We recently reported...
Moser, Janice M., Altman, John D., Lukacher, Aron E.
Polyoma virus is a potent oncogenic pathogen when inoculated into newborn mice of particular H-2k strains. Using Dk tetramers containing the dominant antipolyoma CD8+ T cell epitope, middle T protein...
Andrews, Nicolas P., Pack, Christopher D., Lukacher, Aron E.
The CD8 coreceptor is important for positive selection of major histocompatibility complex I (MHC-I)-restricted thymocytes and in the generation of pathogen-specific T cells. However, the requirement...
An MHC class Ib–restricted CD8 T cell response confers antiviral immunity
Swanson, Phillip A., Pack, Christopher D., Hadley, Annette, Wang, Chyung-Ru, Stroynowski, Iwona, Jensen, Peter E., ...
Although immunity against intracellular pathogens is primarily provided by CD8 T lymphocytes that recognize pathogen-derived peptides presented by major histocompatibility complex (MHC) class Ia...
Shen, Xiao Z., Lukacher, Aron E., Billet, Sandrine, Williams, Ifor R., Bernstein, Kenneth E.
We recently reported a mouse model called ACE 10/10 in which macrophages overexpress the carboxypeptidase angiotensin-converting enzyme (ACE). These mice have an enhanced inflammatory response to...