Arthur L. Castle

Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results (2006)

Castle, Arthur L., Fiehn, Oliver, Kaddurah-Daouk, Rima, Lindon, John C.

Informatics standards and controlled vocabularies are essential for allowing information technology to help exchange, manage, interpret and compare large data collections. In a rapidly evolving...

Water Flow Through Vessel Perforation Plates--A Fluid Mechanical Approach (1993)

SCHULTE, PAUL J., CASTLE, ARTHUR L

The effect of scalariform perforation plates on the flow of water through plant vessels remains poorly understood. In this study, a new computational tool based on finite element method solutions to...

Water Flow Through Vessel Perforation Plates--The Effects of Plate Angle and Thickness for Liriodendron tulipifera (1993)

SCHULTE, PAUL J., CASTLE, ARTHUR L

The effects of scalariform perforation plate thickness and angle within vessel elements of Liriodendron tulipifera were studied with a computational fluid dynamical model. The pressure gradient and...

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...

We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...

In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

Fernández, Ana M., Kim, Jason K., Yakar, Shoshana, Dupont, Joëlle, Hernandez-Sanchez, Catalina, Castle, Arthur L., ...

Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose...

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...

We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

Fernández, Ana M., Kim, Jason K., Yakar, Shoshana, Dupont, Joëlle, Hernandez-Sanchez, Catalina, Castle, Arthur L., ...

Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose...

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...

In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...