Ribot, Wilson J., Panchal, Rekha G., Brittingham, Katherine C., Ruthel, Gordon, Kenny, Tara A., Lane, Douglas, ...
Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and...
Tonie E. Rocke, Jordan Mencher, Susan R. Smith, Arthur M. Friedlander, Gerard P. Andrews, Laurie A. Baeten
Black-footed ferrets (Mustela nigripes) are highly susceptible to sylvatic plague, caused by the bacterium Yersinia pestis, and this disease has severely hampered efforts to restore ferrets to their...
Little, Stephen F., Leppla, Stephen H., Friedlander, Arthur M.
The lethal toxin of Bacillus anthracis consists of two components, protective antigen and lethal factor. Protective antigen is cleaved after binding to cell receptors, yielding a receptor-bound...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States, ~10,000...
Barnard, John P., Friedlander, Arthur M.
The protective efficacy of several live, recombinant anthrax vaccines given in a single-dose regimen was assessed with Hartley guinea pigs. These live vaccines were created by transforming ΔANR and...
Benner, Gretchen E., Andrews, Gerard P., Byrne, W. Russell, Strachan, Susan D., Sample, Allen K., Heath, David G., ...
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we...
Erwin, James L., DaSilva, Luis M., Bavari, Sina, Little, Stephen F., Friedlander, Arthur M., Chanh, Tran C.
We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of...
Antibiotic Treatment of Experimental Pneumonic Plague in Mice
Byrne, William R., Welkos, Susan L., Pitt, M. Louise, Davis, Kelly J., Brueckner, Ralf P., Ezzell, John W., ...
A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience....
Analysis of the Yersinia pestis V Protein for the Presence of Linear Antibody Epitopes
Pullen, Jeffrey K., Anderson, George W., Welkos, Susan L., Friedlander, Arthur M.
The V protein expressed by pathogenic Yersinia pestis is an important virulence factor and protective immunogen. The presence of linear B-cell epitopes in the V protein was investigated by using a...
Needle-Free Skin Patch Vaccination Method for Anthrax
Matyas, Gary R., Friedlander, Arthur M., Glenn, Gregory M., Little, Stephen, Yu, Jianmei, Alving, Carl R.
Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with...
Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., ...
We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States,...
Barnard, John P., Friedlander, Arthur M.
The protective efficacy of several live, recombinant anthrax vaccines given in a single-dose regimen was assessed with Hartley guinea pigs. These live vaccines were created by transforming ΔANR and...
Benner, Gretchen E., Andrews, Gerard P., Byrne, W. Russell, Strachan, Susan D., Sample, Allen K., Heath, David G., ...
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we...
Erwin, James L., DaSilva, Luis M., Bavari, Sina, Little, Stephen F., Friedlander, Arthur M., Chanh, Tran C.
We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of...
Antibiotic Treatment of Experimental Pneumonic Plague in Mice
Byrne, William R., Welkos, Susan L., Pitt, M. Louise, Davis, Kelly J., Brueckner, Ralf P., Ezzell, John W., ...
A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience....
Analysis of the Yersinia pestis V Protein for the Presence of Linear Antibody Epitopes
Pullen, Jeffrey K., Anderson, George W., Welkos, Susan L., Friedlander, Arthur M.
The V protein expressed by pathogenic Yersinia pestis is an important virulence factor and protective immunogen. The presence of linear B-cell epitopes in the V protein was investigated by using a...
Needle-Free Skin Patch Vaccination Method for Anthrax
Matyas, Gary R., Friedlander, Arthur M., Glenn, Gregory M., Little, Stephen, Yu, Jianmei, Alving, Carl R.
Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with...
Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., ...
We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States,...
Ribot, Wilson J., Panchal, Rekha G., Brittingham, Katherine C., Ruthel, Gordon, Kenny, Tara A., Lane, Douglas, ...
Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and...
Scorpio, Angelo, Chabot, Donald J., Day, William A., O'Brien, David K., Vietri, Nicholas J., Itoh, Yoshifumi, ...
The poly-γ-d-glutamic acid capsule confers antiphagocytic properties on Bacillus anthracis and is essential for virulence. In this study, we showed that CapD, a γ-polyglutamic acid depolymerase...
Day, William A., Rasmussen, Suzanne L., Carpenter, Beth M., Peterson, Scott N., Friedlander, Arthur M.
A transposon site hybridization (TraSH) assay was developed for functional analysis of the Bacillus anthracis genome using a mini-Tn10 transposon which permitted analysis of 82% of this pathogen's...
Bozue, Joel, Moody, Krishna L., Cote, Christopher K., Stiles, Bradley G., Friedlander, Arthur M., Welkos, Susan L., ...
Bacillus anthracis is the causative agent of anthrax, and the spore form of the bacterium represents the infectious particle introduced into a host. The spore is surrounded by an exosporium, a...
Treatment of Experimental Anthrax with Recombinant Capsule Depolymerase▿
Scorpio, Angelo, Tobery, Steven A., Ribot, Wilson J., Friedlander, Arthur M.
Bacillus anthracis produces an antiphagocytic gamma-linked poly-d-glutamic acid capsule that is required for virulence. Capsule depolymerase (CapD) is a membrane-associated poly-γ-glutamate-specific...