Thesis (Ph. D.)--University of Medicine and Dentistry of New Jersey, Graduate School of Biomedical Sciences.
Structural Basis for Inhibition of Translation by the Tumor Suppressor Pdcd4▿
LaRonde-LeBlanc, Nicole, Santhanam, Arti N., Baker, Alyson R., Wlodawer, Alexander, Colburn, Nancy H.
The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A...
Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
Santhanam, Arti N., Bindewald, Eckart, Rajasekhar, Vinagolu K., Larsson, Ola, Sonenberg, Nahum, Colburn, Nancy H., ...
Eukaryotic cap-dependent mRNA translation is mediated by the initiation factor eIF4E, which binds mRNAs and stimulates efficient translation initiation. eIF4E is often overexpressed in human cancers....